Thanks lucky man hope 'll get cured before the 5 years.
My next best result would be going from F1 to F0 or becoming HBsAg Negative :)
So here we go, got my results back pre-TAF. Here is everything you need to know (or at least what they took):
HBV DNA IU/mL: < 29 IU/mL HBV DNA Detected
Total Bili: 0.3mg/dL
Dir Bili : < 0.1 mg/dL
Ind Bili :< 0.3 mg/dL
AST (SGOT) - 24 (down 5 points)
ALT (SGPT) - 40 (up 2 points and still NORMAL)
Creatine - 1.14 mg/dL
Uric Acid - 6.3 mg/dL (down 1.2 pts)
Calcium - 9.8 mg/dL
Phosphorus - 4.5 mg/dL
pH - 5.5
CK - 135 U/L (back down 100pts and now normal)
Parathyroid Hormone - 36.2 pg/mL (Slight jump from last test)
HBsAg: Positive :(
Fibr. Score: 0.28
Fibr. Stage: F1, No or Minimal Fibrosis
Other things to be concerned about:
ALPHA-2-MACROGLOBULIN
296 mg/dL (range is 110.0-276.0 mg/dL so it's slightly elevated)
Apolipoprotein A1
106 mg/dL (range is 110-205 mg/dL so it's slightly low)
Osteocal - 56.61 ng/mL (range is 7.30-38.50) -- This has always been high and is associated with the bones. I'm interested to see how this one goes with TAF and if this stabilizes.
Overall, 2 weeks into TAF, I am feeling ok and no real change has occurred. The only thing I get is maybe a little more tired and I end up sleeping in during the weekend mornings, which I was not doing before. But my energy levels are pretty good at night and during the day.
DEXA scan results not in yet so I'll update when they are.
My cholesterol is all normal which is great to see and is even decreasing to the lower end of normal so my diet has been working.
So I meant to post this in October but here were the last and FINAL results from this Clinical Trial. The trial ended and I am now my medication through my insurance. I started this trial in 2014 and I was actually the LAST person on it, from what I was told. I consider myself lucky to be part of this and hope I have helped many with the effectiveness of this treatment of TAF. When I started, I did not know if it was TAF or TDF but since 2016 I knew 100% it was TAF when they officially extended it and put me on it.
As for my final numbers, I am not happy I was NOT cured in all this time. I strongly considered stopping treatment after 7 years when this trial ended on it but my doctor advised me against it. I still have it in my mind that I should maybe attempt to stop and see what happens. He gave me good reasons though such as some numbers and such not being where it should be for me to attempt to stop and see if I can clear it out.
I *was* however, offered to be on 2 clinical trials the past month. I have yet to decide if I want to take part in either but 1 has officially cured one of my doctor's patients. My reluctantcy is due to time constraints, me want to focus on other areas of my health the next 6-8 months and the fact that the trials Interferon treatment later on in the course (something I really don't want to attempt at a younger age for myself)
Here is my final number:
HBV DNA IU/mL: <20 IU HBA DNA Detected (I hate these wordings when it does not say undetectable)
Total Bili: 0.5 mg/dL (Has stayed fairly consistent)
Dir Bili : 0.1 mg/dL
Ind Bili : 0.4 mg/dL
AST (SGOT) - 29
ALT (SGPT) - 37
Creatinine - 1.13 mg/dL
Uric Acid - 8.8 mg/dL (Considered High)
Calcium - 10.0 mg/dL
Phosphorus - 2.4 mg/dL
Cholesterol: 243 mg/dL (Down slightly but I've gained a LOT of weight in the past year and a half due to my inability to exercise right from injuries and surgeries, so I need to refocus)
pH - 6.0
Fibrosis Score: 0.26 (F0-F1 Minimal to No Fibrosis)
CK - 259 (Very high)
AFP: Not Measured This Lab
Osteocal: 28.84 ng/mL
Collagen T1 Crosslaps: 0.59 ng/mL
Parathyroid Hormone - 65.3 pg/mL
HBsAgII: Positive
HBe Ab: Not Measured This Lab
HBe Ag: Not Measured This Lab
HBSAG in Quantitative - 3599.00 IU/mL (This has gone up a lot but I was told this is ok and normal.. which I disagree with)
Vitamin D, 25-Hydroxy - Not Measured This Lab
My glucose was also high for the first time ever. I won't post the number but it has never been high in my life. I am not diabetic but if someone were to see the slight elevation they'd possibly put me there as borderline. This absolutely has everything to do with my weigh gain I am sure.
Anyway, this will be my last post here on this topic. I may start another one and reference my trial posts in there, especially if I *do* opt to go on another trial, but in the meantime, thank you all for your kindness and support and advice over the many years!
Hi All,
So I wanted to share my latest labs regarding this clinical trial. I have been so blessed to been on this trial for 7 years. This was the last time I am getting any free medication from them, unless something changes of course between now and my last appointment. After this, I'm on my own with insurance (but only get 3-6 months worth each time so I hope it's not costly) but the good news is, I don't have to adhere to rules of the trial either but that really doesn't change for me as those rules are the same rules I applied to rules of life. I have fatty liver again so this is something I need to work on with an extreme diet. Not easy for sure and I have another major surgery coming up. With that said, my doctor did discuss another trial with me. It sounds like more of a cure trial that is designed to cure this illness in a year or less. Something new in the works which he is a part of now. Anyway, below is the simple lab I got. Next lab will be more complex and I'll be asking them to measure more that lab as a final lab and will be the last time I am sharing as part of this clinical trial results. I'm considering starting a new thread after that but have not decided. I did ask them about stopping the medication and he said because I did not have positive antibodies, I could not do so. Anyway, good luck to all still going through this! I've been very strong and it's been quite challenging for sure some days!
HBV DNA IU/mL: No HBV DNA Detected
Total Bili: 0.5 mg/dL
Dir Bili : <0.1 mg/dL
Ind Bili : <0.5 mg/dL
AST (SGOT) - 21
ALT (SGPT) - 30
Creatinine - 1.07 mg/dL
Uric Acid - 7.2 mg/dL
Calcium - 9.4 mg/dL
Phosphorus - 3.2 mg/dL
Cholesterol: 247 mg/dL (I really need to reduce this and lose a good 30-40lbs in the process)
pH - 65.5
Fibrosis Score: Not measured this lab
CK - 149
AFP: Not Measured This Lab
Osteocal: Not Measured This Lab
Collagen T1 Crosslaps: Not Measured This Lab
Parathyroid Hormone - Not Measured This Lab
HBsAgII: Positive
HBe Ab: Not Measured This Lab
HBe Ag: Negative
HBSAG in Quantitative - Not Measured This Lab
Vitamin D, 25-Hydroxy - Not Measured This Lab
Thank you for sharing your experiences. CHB is just unknown to us, except what studies are out there on the internet and our personal medical history. Your posts are probably the first real person experience I read.
For me, every 6 months, I feel all could end and life will be so different. Thank you for sharing
Hi All,
Just some updated numbers from the trial. FYI, I was told I may be the last person left on this trial so this time next year, it will be ended. I discussed this with my doctor and he mentioned not to worry about it too much for me, we'll do what we must to either get me on medications to continue them but it's likely a new trial will come out that I would qualify for. At the moment, I do not qualify for any trial.
With that said, in between the last tests I had and this one, I have had some major dental work done as well as a major surgery which required a one night stay in the hospital. My numbers were good before the surgery and my numbers are STILL good after the surgery. They ran additional tests as well to be sure nothing happened after surgery and so far, I am safe. So I'm having no major issues. Here is what I can share:
HBV DNA IU/mL: No HBV DNA Detected (Notice a different result this time? Hmmm)
Total Bili: 0.8 mg/dL
Dir Bili : 0.1 mg/dL
Ind Bili : 0.7 mg/dL
AST (SGOT) - 25
ALT (SGPT) - 37
Creatinine - 1.16 mg/dL
Uric Acid - 7.4 mg/dL
Calcium - 9.9 mg/dL
Phosphorus - 3.3 mg/dL
Cholesterol: 237 mg/dL (While within range, still on the high side of normal, my LDL is definitely high on here)
pH - 6.0
Fibrosis Score: 0.28 (F0-F1 -No or minimal Fibrosis)
CK - 254 U/L (This is really high again)
AFP: Not Measured This Lab
Osteocal: 22.20 1 ng/mL
Collagen T1 Crosslaps: 0.84 ng/mL (This still shows as high but better than last one)
Parathyroid Hormone - 39.5 pg/mL
HBsAgII: Positive -- (Anyone know what it is II now?)
HBe Ab: Not Measured This Lab
HBe Ag: Not Measured This Lab
HBSAG in Quantitative - Not Measured This Lab
Vitamin D, 25-Hydroxy - Not Measured This Lab
Overall, not bad for someone that just had a bunch of other medical stuff going on. I was actually expecting some stuff to be worse but seems like it's just stayed close to the same and nothing alarming. I'll definitely be asking for Vitamin D and HBSAG quantative tests next year again before I am off the trial. One day, I hope there is a cure. I'm ready for my miracle! :)
I wanted to share latest lab tests again. Numbers have improved for some things, fairly good too:
HBV DNA IU/mL: < 20 IU/mL HBV DNA Detected
Total Bili: 0.9 mg/dL
Dir Bili : 0.2 mg/dL
Ind Bili : 0.7 mg/dL
AST (SGOT) - 19 (down 7 pts)
ALT (SGPT) - 28 (down 6 pts)
Creatinine - 1.23 mg/dL (back below the upper limit and within range)
Uric Acid - 8.0 mg/dL (down 1.5pts, the same 1.5 it went up last time)
Calcium - 10.3 mg/dL
Phosphorus - 3.9 mg/dL (up 1 point)
Cholesterol: 207 mg/dL (While within range, still on the high side of normal)
pH - 5.5
CK - 84 U/L (down 160 pts and back in range)
AFP: 1.7 ng/mL
Osteocal: 29.11 ng/mL
Crosslaps: 1.26 ng/mL (This concerns me because it's telling me I have Osteoporosis? And this may explain why I'm feeling weaker later)
Parathyroid Hormone - 23.9 pg/mL
HBsAg: Positive
HBe Ab: Positive
HBe Ag: Negative
Fibrosis Score: Not measured this lab
Fibrosis Stage: Not measured this lab
Additionally, I had the following 2 measured 2 weeks prior to these tests:
HBSAG in Quantitative - 1318.00 IU/mL
Vitamin D, 25-Hydroxy - 133 ng/mL
I do want to add my Ultrasound Findings. If you recall, 6 montths ago, theey discovered what may have been a lesion and fatty liver. The lesion was just a fatty lesion but still concerning. This Ultrasound: "No significant parenchymal abnormalities. Liver Size 13.1cm" this means everything is back to normal. Not even fatty liver!!
Unfortunately, my gallbladder still has problems: Cholelithiasis. Several small polyps measuring 3-5mm in size. Does not say how many this time.
Kidney still has a stable 16 x 19 x 20 mm cyst with mid to inferior right renal cortex
All things considered, especially since I was extremely ill from Feb-March, I'm doing better on my numbers here and thankfully better than I was expecting. I am happy to see the liver has shown drastic improvements overall here. Not sure what to do with gallbladder and kidney though. That is a little bit more tricky. Anyway, just wanted to share. Thanks!
I am worried about your lipid profile.you should rather b concerned more about ur diet and obesity than hbv. U seem a potential candidate for cardiovascular accident. Anyways good luck
Just an update on my numbers here:
HBV DNA IU/mL: < 20 IU/mL HBV DNA Detected
Total Bili: 0.7 mg/dL
Dir Bili : 0.1 mg/dL
Ind Bili : 0.6 mg/dL
AST (SGOT) - 26 (up 3 pts)
ALT (SGPT) - 34 (up 4 pts)
Creatinine - 1.35 mg/dL (this went up and is too high now)
Uric Acid - 9.5 mg/dL (this went up by about 1.5 pts and is also too high now)
Calcium - 10.0 mg/dL
Phosphorus - 2.9 mg/dL (down .4)
pH - 5.5
CK - 244 U/L (up almost 100pts and now way too high)
Parathyroid Hormone - 23.9 pg/mL
HBsAg: Positive
Fibrosis Score: 0.35
Fibrosis Stage: F1-F2 Moderate Fibrosis
Everything else measured was within range. The big concern was with my Cholesterol because my LDL was way too high at 192 mg/dL and my total Cholesterol was 254 mg/dL. Defintiely glad I've gotten on some diet changes and exercises recently.
Additionally, my liver over the past year has gone from pretty much completely normal to a fatty liver to now having a mass on the right lobe of the liver. The mass was measured at 1.4 x 1.3 x 1.4cm and when discovered on the ultrasound, the doctor called me the same day and wanted me to get a MRI. It said: Hyperechoic consistent with hepatic steatosis. There is a new echogenic mass in the right lobe of the liver measuring 1.4 x 1.3 1.4cm" He comforted me a bit saying that this is fairly small and that I should not be too concerned about it, but naturally I've had some worry. I have a MRI scheduled coming up. The ultrasound also showed I had a gallstone (never had one before) and a 3rd polyp on my gallbladder now.
I did ask the doctor about any new clinical trials that may be more towards a cure, especially since I have what is essentially 2 years left on this one at most. He mentioned 2 of them, one from Janssen (Which looks like it was Arrowhead's therapy at some point) and one from Assembly. Here are the two:
This looks like the ARO-HBV now with Janssen. He said he has heard and seen results on this and it looks very promising
http://www.natap.org/2019/HBV/090519_02.htm
He then mentioned Assembly as well, but didn't share details:
https://www.assemblybio.com/programs/hbv/
He wasn't sure if I'd qualify for either just yet but asked I keep an eye on them. Anyway, I'll leave this post at this for now. I'm doing a few things that will definitely benefit me over the course of the next year, stuff I should have focused on the past few years. Better late than never thought! I'll keep you all posted on any findings or progress as it comes along!
Yup, this is still going on for me and I'm happy about it! I think I have 2 more years left. My doctor has been hinting at some of the newer trials in Phase II that are targeting a cure. I may strongly consider if it goes to Phase III or right after this trial is done. Anyway, my results have gotten me down a bit. While I did lose 12lbs since my last visit due to better diet and exercise (go me), 7lbs came right back in 2 weeks. I just don't know how this keeps happening so quick. I want to keep going down, not up. Additionally, my Ultrasound Lab mentions Fatty Liver or Hepatocellur Disease and that just gets me all messed up in the head right now. Increased cyst on my kidney, increased liver size and smaller polyps on my gallbladder (which seem to actually be shrinking).
Regardless of all that, here are my lab result numbers:
HBV DNA IU/mL: HBV DNA < 20 IU/mL Detected (I'd feel comfortable if it said Not Detected again.. still does not say that)
Total Bili: 0.6 mg/dL
Dir Bili : 0.1 mg/dL
Ind Bili : 0.5 mg/dL
AST (SGOT) - 23 (up 2 pts)
ALT (SGPT) - 30 (down 1 pts)
Creatinine - 1.08 mg/dL (down .02)
Uric Acid - 7.9 mg/dL (down .5 and back within normal range)
Calcium - 10.0 mg/dL
Phosphorus - 3.3 mg/dL (up .9)
pH - 5.5 (down ..5)
CK - 157 U/L (up 30)
Parathyroid Hormone - (Not calculated this test)
HBsAg: Positive (The labs say they are supposedly measuring quantitative but I'm only getting this result)
Fibrosis Score: (Not calculated this test)
Fibrosis Stage: Not calculated this test
Some of the things that concerned me last lab, and results this lab:
Cholesterol was a little high at 233 mg/dL (down 2pts but not eno0ugh, my max should be 280)
My C&GCrtClr was 126.7 mL/min (down a few pts, still high as my max should be 125.0)
HAPTOGLOBIN (HPT) (Not Measured this lab)
Direct LDL (Not Measured this lab)
Anyway, wanted to share. I'm praying for a cure for us all sooner rather than later (either naturally or through medicine)! God Bless all!
Good results!
Happy new year to everyone!
Hey everyone, just wanted to offer up my latest test results on this as my trial continues. Looks like I'm done at end of 2020, so 2 years to pray or try and cure myself here before I make a decision whether or not I want to continue meds after 7 years or attempt for a new trial.
Speaking of new trials, I did ask my doctor about the arrowhead/Janssen(JNJ) treatment and if it was in trial. He said he knew of some that were, but was not aware about this one we are talking about on here. I'll have to send him some info since it looks so promising.
Additionally, I've kept off my 5lbs and my blood pressure was normal this time... I really do need to lose about 50lbs though. Maybe I'll work on this in 2019!
Now, the report from the labs:
HBV DNA IU/mL: HBV DNA < 20 IU/mL Detected (I'd feel comfortable if it said Not Detected again)
Total Bili: 0.5 mg/dL
Dir Bili : 0.1 mg/dL
Ind Bili : 0.4 mg/dL
AST (SGOT) - 20
ALT (SGPT) - 31
Creatinine - 1.10 mg/dL
Uric Acid - 8.4 mg/dL (This is high)
Calcium - 9.9 mg/dL
Phosphorus - 2.4 mg/dL
pH - 6.0
CK - 126 U/L (Down a lot)
Parathyroid Hormone - 40.4 pg/ML
HBsAg: Positive (The labs say they are supposedly measuring quantitative but I'm only getting this result
Fibrosis Score: 0.28
Fibrosis Stage: F1, No or Minimal Fibrosis
These are some typical results. There were some things I need to keep and eye on and I noticed they started to add Vitamin Level checks on this report, but they were all normal (Yay!). For the concerning pieces to me:
Cholesterol was a little high at 235 mg/dL (my max should be 280)
My C&GCrtClr was 129.3 mL/min (my max should be 125.0)
HAPTOGLOBIN (HPT) was 203 mg/dL (my max should be 200)
Direct LDL should be <130 mg/dL and mine was high at 182
Guess it's time to really get on a good diet/exercise plan for the new year indeed!!
Happy 2019 to all and here's to hoping for a cure! Stay positive, friends! :)
Been a bit since I updated, figured I'd offer some more and what has happened between my last appointment and this one:
I walked in and found out I'm about 15lbs heavier than I was from December. So I was a tad bit over 230lbs (I'm 5'10" btw)
My blood pressure went up as well, it was a 120/100... not good. I was asked to lose 5-10lbs in 2-4 weeks and monitor blood pressure.
Within 2 weeks, I lost 5lbs and my blood pressure was closer to normal.
Now, the report from the labs:
HBV DNA IU/mL: HBV DNA < 20 IU/mL Detected (Not sure how I go undetected to detected, is it the lab?)
Total Bili: 0.5 mg/dL
Dir Bili : 0.1 mg/dL
Ind Bili : 0.4 mg/dL
AST (SGOT) - 20 (down 6 pts)
ALT (SGPT) - 31 (down 1 pt)
Creatinine - 1.12 mg/dL
Uric Acid - 7.6 mg/dL
Calcium - 9.7 mg/dL
Phosphorus - 3.1 mg/dL
pH - 5.5
CK - 163 U/L (Down a little but in good shape)
Parathyroid Hormone - Not Measured This Lab
HBsAg: Positive
Fibrosis Score: Not Measured This Lab
Fibrosis Stage: Not Measured This Lab
Now for the scary part, the Ultrasound:
Impress: Fatty Liver, Gallbladder polyps, right renal cyst
To give you the basics: Gallblader is 2 polyps, 6mm each. Kidney is lower pole cyst, 13mm. Liver is 13.8cm but no focal abnormality. All of this also showed up on the last test in December.
Anyway, just wanted to share. I'll report back after my next test late this year. Trial continues (Thank goodness) but I need to focus on me and get myself in better shape to eliminate fatty liver and help out my insides.
Since my trial continues to go (I really lucked out on the 5 year extension) then I'll share my results some more from my last visit:
HBV DNA IU/mL: No HBV DNA Detected
Total Bili: 0.6 mg/dL
Dir Bili : 0.1 mg/dL
Ind Bili : 0.5 mg/dL
AST (SGOT) - 26
ALT (SGPT) - 32
Creatinine - 1.20 mg/dL
Uric Acid - 8.2 mg/dL
Calcium - 9.7 mg/dL
Phosphorus - 3.6 mg/dL
pH - 5.5
CK - 162 U/L (Down a little but in good shape)
Parathyroid Hormone - 35.0 pg/mL
HBsAg: Positive
Fibrosis Score: 0.25
Fibrosis Stage:F0-F1, No or minimal Fibrosis
Of note, numbers on mostly everything increased slightly but not alarming and all still fall within range. I had a bad diet in November/December due to holidays so blame that for increased numbers and being a bit overweight (well more than my normal).
Additionally, my cholesterol was on the high side of the cut-off for normal and my blood pressure was VERY high, the worst it was.. I think it was 152/96 which is nowhere near normal for me. What it boils down to, is I need a good diet plan and more exercise. My exercise has been lax in the winter. I want to lose 20-30lbs by my next visit.
Lastly, I was offered the chance to participate in ANOTHER clinical trial by Janssen. My doctor said it aims at a cure within 6 months. I believe it is for:
JNJ56136379: https://clinicaltrials.gov/ct2/show/NCT02662712
It's being brought into the states and was looking for recruits. However, since it's only in Phase 2 and since I would need to go untreated for 6 months to qualify for it before I even start it, I said "No thanks... let's talk when this current trial is over in 2020 and the new one is in Phase 3. Since I don't qualify by being on this trial, and I don't want to go untreated, it could be too dangerous if the virus comes back on a viral load at an alarming rate, or I build a resistance to the meds by going off of it... and all for something that is only 6 months worth of treatment that is not a even guarantee cure yet.
Good report concerning liver but ur uric acid & calcium are at the higher side. Also ur pH (5.5) is wrongly mentioned I suppose?
Want to share more, got my results back today after a 6 month follow up and here's where I am:
Just an update as to where I am with my numbers:
HBV DNA IU/mL: No HBV DNA Detected
Total Bili: 0.3mg/dL
Dir Bili : < 0.1 mg/dL
Ind Bili :< 0.3 mg/dL
AST (SGOT) - 21
ALT (SGPT) - 30
Creatinine - 1.97 mg/dL
Uric Acid - 7.6 mg/dL
Calcium - 9.4 mg/dL
Phosphorus - 3.0 mg/dL
pH - 5.5
CK - 130 U/L (Down a little but in good shape)
Parathyroid Hormone - Not Measured this lab
HBsAg: Positive
Fibrosis Score: Not Measured this lab
Fibrosis Stage:Not Measured this lab
Everything else is in normal range, including my cholesterol which is right in the middle range. I was shocked about this because my diet was not too great two weeks prior to this test but I'll take it. One piece that I am really happy about is that is says DNA Not Detected which prior to this it said "< 29 IU/mL HBV DNA Detected" which meant I may have had a trace of DNA left in me -- or the lab wasn't as sensitive. Either way, the trial continues and I am happy about this, as I *really* need it at this point in life. I'm hoping at my next one, it says HBsAg: Negative. Fingers crossed!
Just an update as to where I am with my numbers:
HBV DNA IU/mL: < 29 IU/mL HBV DNA Detected
Total Bili: 0.3mg/dL
Dir Bili : < 0.1 mg/dL
Ind Bili :< 0.3 mg/dL
AST (SGOT) - 21 (down 2 point)
ALT (SGPT) - 30 (up 9 points)
Creatinine - 1.16 mg/dL
Uric Acid - 6.7 mg/dL (down 1.6)
Calcium - 9.6 mg/dL
Phosphorus - 4.4 mg/dL
pH - 5.5
CK - 107 U/L (Down a little but in good shape)
Parathyroid Hormone - 45.7 pg/mL
HBsAg: Positive
Fibrosis Score: 0.24
Fibrosis Stage: F0-F1, no or minimal Fibrosis
Just a few thoughts:
-Surprised my numbers are as good as they are. I went 1+ year without drinking and had a few around New Year's but back to not drinking any more, so it helps indeed. My suggestion to anyone is just stay away, and you will slowly normalize
-My diet for the holidays was pretty bad too, ironically I lost a little weight and all my other numbers not related to the liver or Chronic Hep B are normal. Generally, I feel well other than some itching of the skin so I need to get back on my diet routines. Thankfully, I know what works.
-I've been fortunate enough to be told that this will continue on for the 5 extra years we agreed to prior to being approved by the FDA. Told the doctor this was something that concerned me as I was afraid it could end, and he too was concerned since they can no longer get anyone on a TAF trial but I was fortunate to get an extension and they are happy that they will be treating me for the time frame we agreed to.
-Generally, I'm feeling ok and just living a normal life but want to make the right steps into what I need to do next. I'm not looking towards any interferon treatments due to the potential sides, but maybe some additional natural ways that won't interfere with the meds. I'd also like to get my HBSAG measured in Quantitative to see where I am at with it and how close I can be to clearing. The trial does measure it, but they don't share the number as they consider it for internal. I heard they offer it in the USA now where I am, but no idea where in the USA these labs are for Quest Diagnostics. Can anyone share and guide me to the steps to get this done? Thanks!
Wanted to share more results. For those that remember, 3 months ago, my ALT and AST took a huge spike and my CK was at an alarming rate. I decided to not work out AT ALL other than doing some yoga. Within those 3 months, I was feeling ok but was feeling some twinges in my thighs for about a month and a half, so my muscles were a concern. It eventually went away but I did mention it to the doctor. Here are my latest results:
HBV DNA IU/mL: < 29 IU/mL HBV DNA Detected
Total Bili: 0.3mg/dL
Dir Bili : < 0.1 mg/dL
Ind Bili :< 0.3 mg/dL
AST (SGOT) - 28 (down 64 points)
ALT (SGPT) - 21 (down 29 points)
Creatinine - 1.20 mg/dL
Uric Acid - 8.3 mg/dL (up .2 pts)
Calcium - 9.2 mg/dL
Phosphorus - 4.4 mg/dL
pH - 5.5
CK - 148 U/L (Back down 3494 pts and into normal)
Parathyroid Hormone - Not measured this lab
HBsAg: Positive
Additionally, I got ultrasound results which showed my liver was completely normal. No damage to it at all. The ALT is the absolute LOWEST I have ever seen it. One thing to mention is that I've been very religious with my Vitamin D daily (10,000-20,000 iu a day) as opposed to a few months ago where I'd miss doses. I was going through a small depression for a few weeks but it wasn't worth mentioning to the doctor as it suddenly changed right on November 1st and I've been happy since.
I was also hoping that HBsAg was going to be negative but I really feel it's just VERY VERY close to changing. This new formula is indeed working the way it's intended to work and I feel better (people have commented I even look better) daily on it. I am scared on what happens with the FDA approval, as I mentioned before in another post, but being that I signed up on an agreement for 5 extra years, I should hope the drug company supplies the drug for the remainder of that time (mainly because I can't afford it monthly even with insurance, and my insurance may not approve it off the bat)... though my doctor did suggest there's a chance they may no longer supply it for free. Ideally, from what I read with FDA approvals and my knowledge of them from working in Pharma, they are supposed to continue on with the trials as a "Phase 4" where they honor the remainder of the trials until they are complete for research purposes while the drug hits the market. Anyway, hope my results help many and God Speed to all!
Yes, to the extent that the speed of regeneration of mitochondrial dna is slowed down, it will lower the amount of mitochondria available for ATP production.
The degree of this effect is likely quite different for different tissues and it is not well known how relevant this effect is.
Other compensatory mechanism to drive mitochondrial biogenesis might become active and reduce the net negative effect, likely depending on a patients age and general health condition.
In the proximal tubuli of the kidneys a large accumulation of split off tenofovir from TDF definitely occurs and reduces the ATP supply of these cells by reduction of the mitochondrial pool size, which explains the negative kidney effects of TDF. Nevertheless this mechanism doesn't lead to a clinical relevant reduction of kidney function in most patients.
Lastly one must be aware that unspecified toxity effects unrelated to mitochondria will exist to a variable degree for all antivirals .
Can you guys write a short version of al this comments/studies so everyone can understand ( i mean "
in everybody's language"). It will be great and we will appreciate.
There is at this time no objective way to test optimal supplementation with nicotinamide riboside. You have to test it clinically and empirically, being alert for problems.
Yes, I am aware of this paper and it feels good to hear that also TDF at 100 times clinical concentrations had no measurable effect on mitochondrial dna synthesis in the cell line used.
The problem is that these company sponsered papers, while well done scientifically, are using a liver cell line derived from a cancer that might not be accurately reflective of the in vivo situation, unfortunately.
if have heard of muscle problems with tenofovir disooroxil fumarate..viread..from a few sources, with seemingly clear on-off testing results.
in the phase I study of entecavir I remember the reporting of substantial neurological problems at the test dose of 10mg in healthy volunteers.
Overall it is important not to vilify these important antivirals, but the overall impression is that these side effects are real and problematic in some patients.