PI's for Geno 4 ?

[Bali05]

Anybody have any idea if the in 2011 expected to be released new drugs are going to be available for geno 4?

When it comes to Tx duration geno 4 is being treated as geno 1 for SOC.There is not much data on geno 4 other than the nitazoxanide trials. I got 2 answers from doctors so far one said Telepravir is only designed to treat geno 1
the other said if it is good for geno 1 it is good for geno 4.Both are very reputable hepatologists.
I don`t think there will ever be a official trial for geno 4 in the US because there are not enough people with it.
All I know of is small trial going on in Ireland with geno 4 and Telepavir.

So what is 2011 going to look like for a geno 4 in the US ?

[Bali05]

thanks , I read thru it.
This new drug seems to be promising yet in a trial setting I might get placebo
and end up straight SOC which for geno 4 means about 50-60% SVR  and 48wks
pretty much for sure.They have 5 arms one being placebo. So that is a 20% chance
of getting placebo. According to Egypt trials from Romark I have a 21% chance
of not getting my SVR with Alinia+SOC.

With Alina it is a possible 79% @48wks and 36wks with early response.
Than there is the 17% chance of clearing Alinia mono. Small but true.
Also if I turn out to be a non responder or relapser on Alinia+SOC I will
have the PIs to retreat with in the future.
A Chief hepatologist told me this as for retreating with Telepravir after Alinia +SOC :

sustained virologic response rate is in the 40% range for nonresponders and 60-70% range for relapsers

Of course that is when Telepravir becomes available they will let me retreat with it
being geno 4.

If I were to do this trial and somehow fail there are no good fall back scenarios
right now.

The whole thing is like a big chess game only that it is not a game!

Anybody with Tx experience is welcome to weigh in please!

[Rockerforlife]

Scroll down to post :"Back From The Doctor",a a member Tom is investigating the same trial,you may wanna check it out.I dont know whole lot but good luck.

[Bali05]

Thanks Rocker for pointing out this trial.Was not aware of it.
Looks like my study location (NYC) is not recruiting yet.

What do you know about RO5024048 (R7128) ?
I have no clue as to what to expect from this. I only know that I am currently naive
and I am looking for the best possible shot which excludes placebo
and SOC by itself.
As a geno 4 should I do Alinia plus SOC or the trial you mentioned above?

What would you do ?

[Rockerforlife]

Isnt this trial taking geno 4`s

http://www.clinicaltrials.gov/ct2/show/NCT00869661?term=RO5024048&rank=2