Aa
I relapsed on SOVALDI and Ribavirin
I have Hep-C G2.
Started SOVALDI and Ribavirin 12 week treatment Dec 23, 2013 (viral load at 2.5 million),
within 4 weeks into treatment my Hep C virus was undetectable.
12 weeks end of treatment my Hep C virus was undetectable.
4 weeks after treatment my Hep C virus was undetected.
12 weeks after of treatment my Hep C virus was detected at 83,000 viral load. It relapsed.
What are my chances of a cure now?
Started SOVALDI and Ribavirin 12 week treatment Dec 23, 2013 (viral load at 2.5 million),
within 4 weeks into treatment my Hep C virus was undetectable.
12 weeks end of treatment my Hep C virus was undetectable.
4 weeks after treatment my Hep C virus was undetected.
12 weeks after of treatment my Hep C virus was detected at 83,000 viral load. It relapsed.
What are my chances of a cure now?
Strong let us know how that works for you sounds promising I'm 2b. No trials going on around here wish there was. Peace
I am in a trial now for genotype 2a, I am 2a/2c. Granted I niave for tx . I am taking sofosbuvir 400 mg and gs-5816 100 mg. On my first week blood work I was 44 viral load and on my second week 15/und. I am in day 36 now and only side effects are vertigo and a foggy mind. I am hoping soon this will be available on the market, suppose to be for all genotypes. Not sure if this can be for you, but don't hurt to look into it.
Did you. Ever start your 24 weeks of tx. I'll be doing 24 weeks also. Found out today it's only option right now for g2 relaspers. Peace
Im presently on sovaldi and olysio. My dr. said that if this doesn't work there will be a one pill regimen coming out in October.
I am very sorry you relapsed on Sovaldi, Inf., Riba. I know it is devastating.
The drug side effects, especially the Interferon, take a few months to get out of your system, but gradually you should feel better. It took me seval months to get back to normal after triple med treatment with Incivek.
Hopefully the ADs will help. Hang in there. You should start feeling better soon, both physically and mentally.
The drug side effects, especially the Interferon, take a few months to get out of your system, but gradually you should feel better. It took me seval months to get back to normal after triple med treatment with Incivek.
Hopefully the ADs will help. Hang in there. You should start feeling better soon, both physically and mentally.
I am a triple null responder, who just finished 12 weeks of Peg/Riba/Sovaldi. At 3 weeks post-tx, my viral load was back to 570,000. Side effects were minimal during treatment...a cakewalk compared to Incivek...but post-treatment sides have been a nightmare. Chronic fatigue and lethargy...unable to get out of bed for a week...haven't been able to go to work or attend college classes...major suicidal depression, started taking ADs again 2 weeks ago...anxiety, and totally compromised quality of life. Am hoping my energy/mood level stabilizes, but at this point feel like a disabled invalid. Glad interferon will be out of the picture in the future.
Absolutely. I'm thankful for all the knowledge I've learned here, an especially the fact that if your at an ideal B.M.I. Your chances of achieving SVR are much greater. THANKS. Mary
Let's try to stay positive and constructive fokes. Hep C is indeed cureable and we will all get there.
Ya think? Also having Hep-C is a strong risk factor for increased liver damage over long term. Right now, I'm battling one thing at a time. Obesity does not affect just the liver but every organ in your body. Thanks for the input
Excess weight is a strong risk factor for increased liver damage over the long term.
I'm real sorry to hear about your relapse. I am encouraged from reading this feed because I was told nothing would be available for GT2 in the near future.. I'm 5'7" an about 190-200 lb. I am concerned about reaching SVR with my size. I soo wanted to extend treatment but... With the price, the insurance would not do it, I'm sure. My G.I. Dr. Doesn't seem concerned when I asked. So I'll just have to wait. Do you know if you'll be eligible for another treatment (. GT2 ). Again, sorry, an keep the faith. Take care. Mary
Tx was 24 weeks peg/rib und 8 weeks. Stayed und relasped at 6 month blood test. 12 weeks sovaldi/rib und all through tx. Relaspe 12 week bliid work. 1200 mg rib. 2 600mg. pills a day.
What dose of Riba were you taking.
The Sovaldi insert has this
Dose of ribavirin is weight-based (<75 kg = 1000 mg and ≥75 kg = 1200 mg). The daily dose of ribavirin is
administered orally in two divided doses with food. Patients with renal impairment (CrCl ≤ 50 mL/min) require
ribavirin dose reduction; refer to ribavirin prescribing information.
https://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/sovaldi/sovaldi_pi.pdf
What was yor duration on each of your treatments and I did you reach undection durning treatment?
Guess I'll be treating again in December. Got the news last week that I too relapsed g2b. This was my second time treating. Don't know what combo I'll be doing this time. Previous sovaldi/ribb. Peg and ribb. Here we go again peace
I heard that two go's worth sovaldi seems to have the highest rate of SVRs....so, as I might be doing, do it again! October is when the new single pill, 12 week treatment begins.
Good luck! Dbz
Good luck! Dbz
I'm certainly no expert, but when you talked about your size it resonated with me a bit because my hepatologist told me that me being 135 and 5'6 gave me good odds (or she hoped) because I was (weight and size proportionate) and these drugs are so new, perhaps they are hammering out dosing as it relates to weight, size, etc....In terms of length of treatment, dosing, etc. To me that's just a guess - I'm not saying anything definitive because I'm no doctor or medical researcher, but I think you're expressing a salient point when you talk about what your doc told you. I just wish you the best and I'm hoping the next time will be the charm for you. I haven't been here much lately (haven't been feeling well due to prolly a number of things, one of which is withdrawing from these drugs, though most people seem to have a much easier time of it) Really, best to you.
I just received my Liver Biopsy results: ZERO fibrosis.
My doctor said that I most likely relapsed because 12 weeks of sovaldi and ribavirin was not long enough due to my size (6',5" 250lb)
I am scheduled to start treatment again, sovaldi and ribavirin 24 weeks
My doctor said that I most likely relapsed because 12 weeks of sovaldi and ribavirin was not long enough due to my size (6',5" 250lb)
I am scheduled to start treatment again, sovaldi and ribavirin 24 weeks
I saw this info awhile back concerning relapsing, as part of a post on another forum. The poster appears to be VERY knowledgeable but the info is not substantiated (because the info comes from a subscription which is not available publically) so please consider that fact when reading. You can easily google part of the text below and find the original post and comments.
-------------
"So why can Sovaldi patients relapse or fail treatment? A very small percentage stop treatment due to side effects. The Prescribing Information has listed various drugs that interfere with Sovaldi absorption and/or action. Other drugs may be added in time. Resistant mutations are the obvious answer. Up to recently, the only resistant mutation discovered was called S282T. Gilead steadfastly said this was only found in one patient who relapsed. This mutation is a change in the 282 protein, and evidently the variant with the S,T variation, interferes with action of the Sovaldi tri-phosphate. It rapidly mutates back to S282S which is not a problem. It has been shown that this S282T mutation can only occur in Genotypes 1b, 2a & b, and 3a. So, if you don't have those Genotypes, you would assume you were safe. Now, new RAV's have been found. M289L in Geno 2a, L159F in Geno 1a, 2b and C316N in Geno 1b. These are said to 'interfere' with the action of Sovaldi and lessen it's effectiveness. Post-transplant patients treated with Sovaldi developed a RAV called V321A but only those with Geno 3a. So it seems that Sovaldi has a very high barrier to resistance, but resistant mutations can indeed develop. This is why the second antiviral is required as backup. Although Ribavirin is a good antiviral, we still don't know exactly how it works, and it has side effects. The addition of another new DAA will give the best results, so Olysio has been given it's chance. When Ledispavir or Daclatasvir are approved, this will be the combo of choice, and we should be approaching the 100% SVR goal..Thanks for listening!"
-------------
"So why can Sovaldi patients relapse or fail treatment? A very small percentage stop treatment due to side effects. The Prescribing Information has listed various drugs that interfere with Sovaldi absorption and/or action. Other drugs may be added in time. Resistant mutations are the obvious answer. Up to recently, the only resistant mutation discovered was called S282T. Gilead steadfastly said this was only found in one patient who relapsed. This mutation is a change in the 282 protein, and evidently the variant with the S,T variation, interferes with action of the Sovaldi tri-phosphate. It rapidly mutates back to S282S which is not a problem. It has been shown that this S282T mutation can only occur in Genotypes 1b, 2a & b, and 3a. So, if you don't have those Genotypes, you would assume you were safe. Now, new RAV's have been found. M289L in Geno 2a, L159F in Geno 1a, 2b and C316N in Geno 1b. These are said to 'interfere' with the action of Sovaldi and lessen it's effectiveness. Post-transplant patients treated with Sovaldi developed a RAV called V321A but only those with Geno 3a. So it seems that Sovaldi has a very high barrier to resistance, but resistant mutations can indeed develop. This is why the second antiviral is required as backup. Although Ribavirin is a good antiviral, we still don't know exactly how it works, and it has side effects. The addition of another new DAA will give the best results, so Olysio has been given it's chance. When Ledispavir or Daclatasvir are approved, this will be the combo of choice, and we should be approaching the 100% SVR goal..Thanks for listening!"
Main reason I switched dr was first guy I was seeing was swamped. If I had appt at 1300 wouldn't see doc until 1530 or later. Peace
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