I’m so happy I came across this forum. I see that I am not alone in my experience. Like many here, I suffer from long term side effects from my one year, combo (peg & ribo) tx in 2003 at Kaiser Permanente. I am blessed… my tx cleared the virus, but it is a mixed blessing, because my quality of life has never been the same. During the treatment, I became so violently ill my doctor took me off the tx for 2 weeks at the 6 mos. Mark, because I was so sick and emotionally unstable. I didn’t want to have gone through the hell of the first 6 mos. and not finish, with a chance of clearing after 1 year, so I pulled it together as best I could to finish the year. I was not warned about any of this prior to treatment, and had no idea what I was in for, and there was NO “Black Box” warning on any of my tx meds. I was able to work ½ days for the first 2 mos, or so, but then became totally dysfunctional and unable to go outside the house, let alone work. For the remainder of the tx, I could make it until about 11am each day and then was in bed shaking violently for the rest of the day and most of the night. I could sleep only a few hours a night, and as the treatment continued the side effects got worse. I experienced severe depression, anxiety, panic attacks, paranoia, insomnia, and some degree of psychosis. I had never experienced any of these psychiatric illnesses prior to the tx. I was under constant psychiatric care and was prescribed every anti-depressant made, in max doses, in a vain attempt to control these symptoms. I was also given numerous non-addictive, anti-anxiety medications. I was also given very low doses of tranquilizers, which did help, but because of the (addict) stigma attached to having contracted the disease, the doses I received were too low to be effective for the awful panic and anxiety I was experiencing. I lost 50 lbs and was a pale grey in color. I now suffer from PTSD, severe depression, anxiety and panic attacks. It has been eight years of this. I still take multiple psychiatric meds, and I’m able to function at work and home, but that is the extent of it… I am able to function. The panic and anxiety I experience on the job has dramatically impaired my ability to excel. I know that not everyone has suffered or will suffer this much, but some may and should, at least, know that long-term trauma and dysfunction is indeed a possible “side effect”! Is anyone else out there experiencing similar long-term side effects from this tx?