Aa
Aa
A
A
A
Close
2035311 tn?1332679977

Mutation type?

Is there any way of finding out what type of mutation I had?  I was on Telaprevir, Peg, riba for 8 weeks.  My VL went down to 490 from 11 million and then went up to 22,000 @ 8 weeks.  Is that info in my blood work or is there no way of finding out what happened?
13 Responses
Sort by: Helpful Oldest Newest
1835200 tn?1427460238
We seem to be getting off topic from the originial question....but anyway...to javi1962, there is a rescue arm for the all oral Gilead trial that would add INF/Riba/SOC to the mix. As where I believe UKgirl is going, if you are a previous null responder and/or a CT or TT your chances of success, SVR, are low. You have developed some resistant mutations. There are some folks on this forum that have added the INF and have gone UND again. Best of luck.
Helpful - 0
Avatar universal
Do you know what your IL28b is?
Helpful - 0
Avatar universal
I've screened for the same trial. I wish they'd ammend this trial now. Right now the rescue is SOC....Oh, thanks, but no thanks!
Helpful - 0
Avatar universal
Maybe, given the results w/ nulls on 7977+Riba for 12 wks, you could ask them if they'd allow you to roll over to 24 wks if you're still UD on tx if others who finish ahead of you in the trial should relapse post tx??  Are you at Weill? And what's your IL28B?  Good luck and please keep us posted as to what you think you'll do.
Helpful - 0
2035311 tn?1332679977
You guys are freakin amazing.  What a wealth of knowledege and support you all are. It's very encouraging to me.

@co1251  I had the 1st screening Friday and am waiting for a call this week.
I have not decided yet. Gathering info. Asking ?
I wish I could do 24 weeks with 7977, BMS, and Riba.  

@Javi  What drugs were you on?
@nowine  Yes GT 1a

Helpful - 0
Avatar universal
Do you know how long you'll have to wait before you can do the 7977 trial? They're going to be coming out with a lot more trials. I'd ask them what the washout period is.
Helpful - 0
Avatar universal
I just failed the all oral therapy Gilead, I went und at week 2, und at 4 then 2800 at week 6, they asked me to come back in 6 weeks so they can do test for mutations, to see which ones I had and how there maturing, something like that nurse said. this ***** because the trial I wanted originally was all oral PSI 7977 and this was only available for geno 3 and 2 and now the study nurse called me saying its open to geno 1a which I am, but due to accepting this Gilead trial in December and failing, I cannot do it right now.
Helpful - 0
Avatar universal
It's my understanding that there are two different possible causes for failure with triple therapy:  1) the individual patient's response to IFN/RBV treatment given the IL28B allele (CC tends to respond better, CT responds relatively well, and TT tends to have a poorer response), and 2) the selection of pre-existing variants during therapy (the protease inhibitors select for genetic variations of the virus that already existed prior to treatment and were unfit but were then selected and replicated during therapy).  I'm not sure, but perhaps an individual who failed triple therapy could have 1) or 2) or both occur.
Advocate1955
Helpful - 0
1835200 tn?1427460238
Just curious...is your g-type 1a?

Another link for you.

http://www.natap.org/2011/hepDART/hepDART_12.htm
Helpful - 0
1835200 tn?1427460238
Sorry to hear 3x treatment failed for you. You are not alone. Here is a link that gives an overview on resistance mutations to protease inhibitors. This was given to us earlier by epicrose who has since disappeared from this forum. Best of luck.

http://74.43.177.57/courses/2010/pg/pawlotsky/player.html
Helpful - 0
Avatar universal
Here ya go...


http://www.natap.org/2011/HCV/MgrmGenoSureHCVclientletter%20FINAL2011.pdf

Helpful - 0
Avatar universal
Jimeeboy, There's a test, think it's called GenoSure, that can be done to determine what resistance  and genetic mutation you had in response to Telaprevir (or Boceprevir).
Btw, read your comments the other day and am wondering what you're thinking now about screening for the BMS/7977 trial?  Good luck with everything!
Helpful - 0
1669790 tn?1333662595
The IL28B test is available by a few different labs to aid in the prediction of patient response to peginterferon alpha-based therapy for HCV infection.  Discuss with your doctor if they want to consider doing the test.  

http://www.hepatitis-central.com/mt/archives/2011/04/il28b_diagnosti.html
Helpful - 0
Have an Answer?

You are reading content posted in the Hepatitis C Community

Top Hepatitis Answerers
317787 tn?1473358451
DC
683231 tn?1467323017
Auburn, WA
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Answer a few simple questions about your Hep C treatment journey.

Those who qualify may receive up to $100 for their time.
Explore More In Our Hep C Learning Center
image description
Learn about this treatable virus.
image description
Getting tested for this viral infection.
image description
3 key steps to getting on treatment.
image description
4 steps to getting on therapy.
image description
What you need to know about Hep C drugs.
image description
How the drugs might affect you.
image description
These tips may up your chances of a cure.
Popular Resources
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Herpes sores blister, then burst, scab and heal.
Herpes spreads by oral, vaginal and anal sex.
STIs are the most common cause of genital sores.
Condoms are the most effective way to prevent HIV and STDs.
PrEP is used by people with high risk to prevent HIV infection.