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SOCS3 Gene: Insulin Resistance, IFN resistance
For six years, I believed there was a single-source connection between interferon resistance and interferon resistance. It is, as I suspected, a gene. The gene is SOCS3 - Suppressor Of Cytokine Signaling-3. The discovery of this gene also sheds some light on why prior nonresponders have more trouble acheiving SVR.
1. SOCS-3 is elevated by HCV's core protein.
2. SOCS-3 elevation causes interferon resistance.
3. SOCS-3 elevation causes insulin resistance in the liver.
4. SOCS-3 depletion reduces liver insulin resistance, but causes systemic insulin resistance.
5. SOCS-3 is further elevated in people who have treated unsuccessfully.
These findings suggest a new and viable target for therapy.
1. SOCS-3 is elevated by HCV's core protein.
2. SOCS-3 elevation causes interferon resistance.
3. SOCS-3 elevation causes insulin resistance in the liver.
4. SOCS-3 depletion reduces liver insulin resistance, but causes systemic insulin resistance.
5. SOCS-3 is further elevated in people who have treated unsuccessfully.
These findings suggest a new and viable target for therapy.
Just found this thread and it was so interesting I had to add my experience which is purely anecdotal and is not part of a study.:)
I have diabetes, while on the last tx in 2008 I was so sick I did not watch my sugar but the weekly draws showed it was fine so I continued on and relapsed.
This time pretx I am seriously watching my sugar, taking Metformin, while logically I know it doesn't mean much however my viral load has gone from over 6M to 350K since starting in April and my ALT and AST are both at 21. Something is happening.
I pray this enough to get me to SVR when I start tx, thanks for this post
Dee
I have diabetes, while on the last tx in 2008 I was so sick I did not watch my sugar but the weekly draws showed it was fine so I continued on and relapsed.
This time pretx I am seriously watching my sugar, taking Metformin, while logically I know it doesn't mean much however my viral load has gone from over 6M to 350K since starting in April and my ALT and AST are both at 21. Something is happening.
I pray this enough to get me to SVR when I start tx, thanks for this post
Dee
Is there anything actually incorrect with what Co has posted.
Cause if there is i have also got it wrong.
What is your point with this, or are you just trying to stir up trouble
Why are you a member here.
Your 4 posts so far have been breathtaking in their Brevity and pontlessness.
CS
Cause if there is i have also got it wrong.
What is your point with this, or are you just trying to stir up trouble
Why are you a member here.
Your 4 posts so far have been breathtaking in their Brevity and pontlessness.
CS
My understanding is that the longer I stay on an insulin sensitizer the more good years I'll get out of my pancreas. I went on a fairly strict 'chef salad' diet when first dx with diabetes, but since I've dropped under 190 I've been adding more fats and carbs back into my diet.
That is great news for you Did you have a special diet? Have you stopped teh Metformin and can you keep the weight off? thanks for posting
Baja
Baja
A couple points:
1) Getting rid of the virus didn't automatically fix my steatosis or IR. Ultrasound at 1 year and 4 years post-tx showed NAFLD. Diagnosed with diabetes 5 years post-tx. After carrying a geno 3 virus for almost 30 years, damge done, even though 2001 bx showed only mild fibrosis.
2) Metformin worked where diet and exercise didn't.
6'2"
225 lb. pre-tx
220 lb. EOT
230 lb. post-tx
All the low carb / no carb diet and exercise for 5 years post-tx was only able to budge my weight +or- 5lb. Lost 40 lb in 6 months taking Metformin and my glucose is the best it's been in years.
1) Getting rid of the virus didn't automatically fix my steatosis or IR. Ultrasound at 1 year and 4 years post-tx showed NAFLD. Diagnosed with diabetes 5 years post-tx. After carrying a geno 3 virus for almost 30 years, damge done, even though 2001 bx showed only mild fibrosis.
2) Metformin worked where diet and exercise didn't.
6'2"
225 lb. pre-tx
220 lb. EOT
230 lb. post-tx
All the low carb / no carb diet and exercise for 5 years post-tx was only able to budge my weight +or- 5lb. Lost 40 lb in 6 months taking Metformin and my glucose is the best it's been in years.
I haven't read enough to know the particulars but if the study is as you describe then - No, I do not think that an EVR of 71% would be likely through diet/weight loss alone.
I have been diabetic since my transplant in 2000. I am a control freak with my glucose - my HBA1c from 5 months ago was a flat 4. Anyway, I was an EVR when I was dosed correctly with Peg/Riba and I did achieve SVR - I treated for 73 weeks to get there but I did get there. I was not overweight and I believe that if I hadn't controlled my glucose as tightly as I did it is possible and maybe likely that I wouldn't have reached SVR. And I tend to believe that for many who are IR weight loss alone might not be enough. Drugs very well might be the key. Perhaps for those people who are able to lose enough weight and achieve a corresponding insulin response diet is enough. I think we both agree that significant weight loss does confer a significant benefit in those patients who are overweight or obese. But from the little I know I too am excited about Metformin. I just don't know enough to be really confident at this point. But it looks good from here - very good!
Mike
I have been diabetic since my transplant in 2000. I am a control freak with my glucose - my HBA1c from 5 months ago was a flat 4. Anyway, I was an EVR when I was dosed correctly with Peg/Riba and I did achieve SVR - I treated for 73 weeks to get there but I did get there. I was not overweight and I believe that if I hadn't controlled my glucose as tightly as I did it is possible and maybe likely that I wouldn't have reached SVR. And I tend to believe that for many who are IR weight loss alone might not be enough. Drugs very well might be the key. Perhaps for those people who are able to lose enough weight and achieve a corresponding insulin response diet is enough. I think we both agree that significant weight loss does confer a significant benefit in those patients who are overweight or obese. But from the little I know I too am excited about Metformin. I just don't know enough to be really confident at this point. But it looks good from here - very good!
Mike
It didnt work so i didnt finish the pack, but it did give me a sweet tooth.
So yeh i'd say it raised enzymes
CS
So yeh i'd say it raised enzymes
CS
"I searched the Champix drug Varenicilina and it seems ok what was your take on it CS?"
There have been several cases of elevated liver enzymes caused by it.
Co
There have been several cases of elevated liver enzymes caused by it.
Co
So you guys think that because my liver started healing itself - it stopped producing SUGAR.. SUGAR.. Sugar.
And the sugar is melting offa my hipsters?
Hmmm..
LMAO!
That's kinda funny.
And the sugar is melting offa my hipsters?
Hmmm..
LMAO!
That's kinda funny.
"Knowing more about each individual as an individual instead of lumping all together"
You said it best.
Co
You said it best.
Co
"think CO would advise obese patients to try and lose weight."
You know me well. :) Besides teaching them about IR, I put them in my nutrition class.
"Perhaps I am being presumptuous but my impression is that she believes that Metformin can also be a significant aid in reducing IR in patients who don't achieve the goal through weight loss alone"
And it may also aid weight loss.
Using insulin sensitizers worked for co-infected patients and non-responders. Give me your honest opinion. Do you think weight loss/diet would give them a 71% EVR?
It isn't that I believe that people are lazy or not determined to loose weight.....it's that some of them just can't.
People are willing to double dose and face whatever risk for a chance at less than 71%. Now there's a new option.....and I'm really excited.
Co
You know me well. :) Besides teaching them about IR, I put them in my nutrition class.
"Perhaps I am being presumptuous but my impression is that she believes that Metformin can also be a significant aid in reducing IR in patients who don't achieve the goal through weight loss alone"
And it may also aid weight loss.
Using insulin sensitizers worked for co-infected patients and non-responders. Give me your honest opinion. Do you think weight loss/diet would give them a 71% EVR?
It isn't that I believe that people are lazy or not determined to loose weight.....it's that some of them just can't.
People are willing to double dose and face whatever risk for a chance at less than 71%. Now there's a new option.....and I'm really excited.
Co
Thank you for a very interesting read which has very much to do with me and many others that are pre tx in considering what they will be speaking to their Doctors about
I for one would not have known I was IR if it was not for CO thank you a million times
Knowing more about each individual as an individual instead of lumping all together for the same SOC is surely an advantage for SVR but taking it one step further with more studies can also prevent some sx that are miserable for people always I hear every one is different but yet they are not treated differently before tx all have the same tests going in most concerned with Viral Load and Genotype but very little else is looked at
in relation to an indivduals symptoms that brought them to the doctor in the first place
one could have many other factors besides HCV that need to be addressed before Tx I would assume if this was SOC then maybe the patient would not have to have so many uncomfortable sx in tx just a thought
Genetics would play a very important role
Lifestyle right up there with Genetics
Other conditions such as IR Fibromyalgia Lupus Arthritis and any other pre exsiting disorders which with todays population and current lifestyle of todays population
I would think Males and Females would also have different issues as well
All very interesting to say the least Since these conditions are not considered in most cases and there is a rush to tx It would seem in trials they would make is SOC
The main objective not to sell drugs but the ultimate goal of SOC
The smoking issue little to be found but since I smoke and am Insulin resistant there are many studies done on it I just typed in Insulin Resistance and Smoking and sure enough no one should smoke as they should not drink Alcohol prior to tx
Nor should any one be obese however the weight issue and smoking are two difficult issues for most people to control which is why I feel there is a real good need for pre treatment thorough dx and then tx just a thought
CS why did you say not to use Champix for quitting smoking I have used the patch the gum have not had any luck with the gum but have had luck with the patch in the past however with all the worry over this situation I am dieting good diet and starting with excercising 3 times a week and will increase Smoking is one thing very difficult for me
to stop at this time so anxed up about this HCV I find my self smoking more need an aid to quit diet has come easy the excercise not so easy but doing it
I searched the Champix drug Varenicilina and it seems ok what was your take on it CS?
Still need a Fibroscan I am betting there is one here in Mexico so will look here if I do not hear back about one in LA all the best and I will keep asking questions
thanks again super thread
Baja
I for one would not have known I was IR if it was not for CO thank you a million times
Knowing more about each individual as an individual instead of lumping all together for the same SOC is surely an advantage for SVR but taking it one step further with more studies can also prevent some sx that are miserable for people always I hear every one is different but yet they are not treated differently before tx all have the same tests going in most concerned with Viral Load and Genotype but very little else is looked at
in relation to an indivduals symptoms that brought them to the doctor in the first place
one could have many other factors besides HCV that need to be addressed before Tx I would assume if this was SOC then maybe the patient would not have to have so many uncomfortable sx in tx just a thought
Genetics would play a very important role
Lifestyle right up there with Genetics
Other conditions such as IR Fibromyalgia Lupus Arthritis and any other pre exsiting disorders which with todays population and current lifestyle of todays population
I would think Males and Females would also have different issues as well
All very interesting to say the least Since these conditions are not considered in most cases and there is a rush to tx It would seem in trials they would make is SOC
The main objective not to sell drugs but the ultimate goal of SOC
The smoking issue little to be found but since I smoke and am Insulin resistant there are many studies done on it I just typed in Insulin Resistance and Smoking and sure enough no one should smoke as they should not drink Alcohol prior to tx
Nor should any one be obese however the weight issue and smoking are two difficult issues for most people to control which is why I feel there is a real good need for pre treatment thorough dx and then tx just a thought
CS why did you say not to use Champix for quitting smoking I have used the patch the gum have not had any luck with the gum but have had luck with the patch in the past however with all the worry over this situation I am dieting good diet and starting with excercising 3 times a week and will increase Smoking is one thing very difficult for me
to stop at this time so anxed up about this HCV I find my self smoking more need an aid to quit diet has come easy the excercise not so easy but doing it
I searched the Champix drug Varenicilina and it seems ok what was your take on it CS?
Still need a Fibroscan I am betting there is one here in Mexico so will look here if I do not hear back about one in LA all the best and I will keep asking questions
thanks again super thread
Baja
If that is her position, then I also agree with her.
But unless I'm reading things wrong, that has been MY position, not hers, but maybe I'm reading things wrong.
But once again, my opinion is that in the majority of cases you try weight loss and lifestyle changes first, then try something like Metformin if that doesn't work. And yes, where IR presents itself and there isn't a weight problem, it's not just a matter of losing weight.
-- Jim
But unless I'm reading things wrong, that has been MY position, not hers, but maybe I'm reading things wrong.
But once again, my opinion is that in the majority of cases you try weight loss and lifestyle changes first, then try something like Metformin if that doesn't work. And yes, where IR presents itself and there isn't a weight problem, it's not just a matter of losing weight.
-- Jim
I think CO would advise obese patients to try and lose weight. Perhaps I am being presumptuous but my impression is that she believes that Metformin can also be a significant aid in reducing IR in patients who don't achieve the goal through weight loss alone and for those patients who are IR and don't have a weight problem. If that is her position I agree with her and if it isn't I still agree with the position.
Mike
Mike
From memory, Agaston states that a low-carb diet like South Beach can bring IR and metabolic syndrome under control, therefore diet should be a first-line treatment.
CO, But they can "be enough" in some cases and that's why they should be (and are recommended) as a first-line treatment IR in many cases. If your personal opinion is that people aren't motivated enough to do the hard work, that's another story. And I'm still not clear on your position -- would you ask your IR patients to try and lose weight and make lifestyle changes before administering a drug like Metaformin -- do you even give them a choice -- or do you just skip that step and put them right on Metaformin?
CO, But they can "be enough" in some cases and that's why they should be (and are recommended) as a first-line treatment IR in many cases. If your personal opinion is that people aren't motivated enough to do the hard work, that's another story. And I'm still not clear on your position -- would you ask your IR patients to try and lose weight and make lifestyle changes before administering a drug like Metaformin -- do you even give them a choice -- or do you just skip that step and put them right on Metaformin?
"As for losing weight, I doubt anyone would diagree in princple.
But as the South Beach Diet indicates being overweight can be caused by IR.
From memory doesnt Agatston state that being overweight is a direct result of a high carb diet. Leptin is also getting the blame in similar diets ie rosedale. All gets a bit circular i know. Being over weight leads to IR. IR leads to weight gain."
Thank YOU!
Of course I'm not saying lifestyle changes aren't important. I'm just saying they're not enough.
Co
But as the South Beach Diet indicates being overweight can be caused by IR.
From memory doesnt Agatston state that being overweight is a direct result of a high carb diet. Leptin is also getting the blame in similar diets ie rosedale. All gets a bit circular i know. Being over weight leads to IR. IR leads to weight gain."
Thank YOU!
Of course I'm not saying lifestyle changes aren't important. I'm just saying they're not enough.
Co
Just to make it clear i believe that we should try and resolve IR before we start Tx.
Using whatever means we can.
I dont like the way some of these studies similstart Insulin sensitising drugs with the first shot of IFN. Seeing as IFN can induce IR yet at the same time also resolve it.
CS
Using whatever means we can.
I dont like the way some of these studies similstart Insulin sensitising drugs with the first shot of IFN. Seeing as IFN can induce IR yet at the same time also resolve it.
CS
Say one thing about CoWriter, She is passionate.
As for losing weight, I doubt anyone would diagree in princple.
But as the South Beach Diet indicates being overweight can be caused by IR.
From memory doesnt Agatston state that being overweight is a direct result of a high carb diet. Leptin is also getting the blame in similar diets ie rosedale. All gets a bit circular i know. Being over weight leads to IR. IR leads to weight gain.
In otherwords I guess Co is saying if you resolve IR then the weight loss will look after itself as it did in Meki's case. Which is also what Agatston is saying.
No simple answers really
CS
PS Meki, I'll try and answer you Posts Questions Tonite. My Tonite that is.
As for losing weight, I doubt anyone would diagree in princple.
But as the South Beach Diet indicates being overweight can be caused by IR.
From memory doesnt Agatston state that being overweight is a direct result of a high carb diet. Leptin is also getting the blame in similar diets ie rosedale. All gets a bit circular i know. Being over weight leads to IR. IR leads to weight gain.
In otherwords I guess Co is saying if you resolve IR then the weight loss will look after itself as it did in Meki's case. Which is also what Agatston is saying.
No simple answers really
CS
PS Meki, I'll try and answer you Posts Questions Tonite. My Tonite that is.
CO: You can be insulin resistant without being overweight.
--------------
That's correct, and you can also have fatty liver without being overweight -- but that was not my point. The fact that you can have fatty liver without being overweight does not mean that IF you're overweight, one should necessarily dispense with first line treatment, i.e. weight loss and lifestyle changes. And as far as I know, this prinicple holds true whether the IR is caused by Hep C or not. That's why good liver specialists have (and still are) recommed weight loss and lifestyle changes to their overweight patients.
And to be clear, as the sub-text of some of these posts may suggest to some -- I am not against treating IR whatever means is deemed appropriate, not do I have any pic with the current studies, not do have any illusions that the medical profession as a whole has been on top of this situation.
Quite the contrary. The medical profession as a whole has been behind the curve on both IR as well as many other issues, and that's one of the reasons why a place like this is such a valuable resource. It's also why I, and others, always urge people to seek out the best possible liver specialist they can reasonably find, because top line liver specialists tend to be ahead of the curve, not behind it.
So please, let's not turn this into an argument, because I'm not sure what we're arguing here, unless you don't believe that recommending weight loss and lifestyle changes to an overweight patient with IR is not a reasonable first approach.
-- Jim
--------------
That's correct, and you can also have fatty liver without being overweight -- but that was not my point. The fact that you can have fatty liver without being overweight does not mean that IF you're overweight, one should necessarily dispense with first line treatment, i.e. weight loss and lifestyle changes. And as far as I know, this prinicple holds true whether the IR is caused by Hep C or not. That's why good liver specialists have (and still are) recommed weight loss and lifestyle changes to their overweight patients.
And to be clear, as the sub-text of some of these posts may suggest to some -- I am not against treating IR whatever means is deemed appropriate, not do I have any pic with the current studies, not do have any illusions that the medical profession as a whole has been on top of this situation.
Quite the contrary. The medical profession as a whole has been behind the curve on both IR as well as many other issues, and that's one of the reasons why a place like this is such a valuable resource. It's also why I, and others, always urge people to seek out the best possible liver specialist they can reasonably find, because top line liver specialists tend to be ahead of the curve, not behind it.
So please, let's not turn this into an argument, because I'm not sure what we're arguing here, unless you don't believe that recommending weight loss and lifestyle changes to an overweight patient with IR is not a reasonable first approach.
-- Jim
That's right.
Co
Association among cigarette smoking, metabolic syndrome, and its individual components: the metabolic syndrome study in Taiwan.
Chen CC, Li TC, Chang PC, Liu CS, Lin WY, Wu MT, Li CI, Lai MM, Lin CC.
Division of Endocrinology and Metabolism, Department of Medicine, China Medical University Hospital, Taichung 404, Taiwan.
Insulin resistance is a common feature of metabolic syndrome. Smokers are at great risk of developing insulin resistance. Theoretically, smoking status should be associated with metabolic syndrome. This study aimed to explore the association among cigarette smoking, metabolic syndrome, and its individual components. Information of participants regarding previous and current diseases, family history of disease, smoking habits, alcohol consumption, betel nut chewing, and physical activity status were gathered from self-reported nutrition and lifestyle questionnaires. The fasting plasma glucose, triglyceride level, high-density lipoprotein cholesterol (HDL-C) level, blood pressure, and anthropometric indices in each patient were measured. Data of 1146 male subjects were analyzed. Individuals who currently smoked had a higher prevalence of metabolic syndrome than those who had never smoked and those who had quit smoking. The adjusted odds ratios of current smoking amount showed a statistically significant dose-dependent association with metabolic syndrome, high triglyceride level, and low HDL-C level. Current smokers who smoke > or =20 pack-years have a significantly increased risk of developing metabolic syndrome, high triglyceride level, and low HDL-C level. The higher risk of development of metabolic syndrome, high triglyceride level, and low HDL-C level was insignificant in former smokers. In conclusion, this community-based study supports the view that smoking is associated with metabolic syndrome and its individual components. Smoking cessation is beneficial to metabolic syndrome and its individual components.
http://www.ncbi.nlm.nih.gov/pubmed/18328358?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Co
Association among cigarette smoking, metabolic syndrome, and its individual components: the metabolic syndrome study in Taiwan.
Chen CC, Li TC, Chang PC, Liu CS, Lin WY, Wu MT, Li CI, Lai MM, Lin CC.
Division of Endocrinology and Metabolism, Department of Medicine, China Medical University Hospital, Taichung 404, Taiwan.
Insulin resistance is a common feature of metabolic syndrome. Smokers are at great risk of developing insulin resistance. Theoretically, smoking status should be associated with metabolic syndrome. This study aimed to explore the association among cigarette smoking, metabolic syndrome, and its individual components. Information of participants regarding previous and current diseases, family history of disease, smoking habits, alcohol consumption, betel nut chewing, and physical activity status were gathered from self-reported nutrition and lifestyle questionnaires. The fasting plasma glucose, triglyceride level, high-density lipoprotein cholesterol (HDL-C) level, blood pressure, and anthropometric indices in each patient were measured. Data of 1146 male subjects were analyzed. Individuals who currently smoked had a higher prevalence of metabolic syndrome than those who had never smoked and those who had quit smoking. The adjusted odds ratios of current smoking amount showed a statistically significant dose-dependent association with metabolic syndrome, high triglyceride level, and low HDL-C level. Current smokers who smoke > or =20 pack-years have a significantly increased risk of developing metabolic syndrome, high triglyceride level, and low HDL-C level. The higher risk of development of metabolic syndrome, high triglyceride level, and low HDL-C level was insignificant in former smokers. In conclusion, this community-based study supports the view that smoking is associated with metabolic syndrome and its individual components. Smoking cessation is beneficial to metabolic syndrome and its individual components.
http://www.ncbi.nlm.nih.gov/pubmed/18328358?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
The insulin resistance caused by Hep C is actually hepatic hyperglycemia. It's not the same as the simple antagonism of PPAR gamma of adipose tissue associated with Type 2 diabetes.
In some people, Hep C causes the liver to disgorge huge amounts of glucagon. This kind of sugar infusion would overwhelm most people's ability to produce enough insulin to control it.
You can be insulin resistant without being overweight.
In some people, Hep C causes the liver to disgorge huge amounts of glucagon. This kind of sugar infusion would overwhelm most people's ability to produce enough insulin to control it.
You can be insulin resistant without being overweight.
JM: .."many liver specialists having been asking patients to lose weight for some time prior to treatment -- so even without specific studies they have been connecting the dots..."
_____________________________
Really? Let's see. Here's what a couple of hepatologists said in response to these questions back in Sept 2005.....
-----------------------
Yes, "really" MS sarcastic one these days.
Please read again my statement, and your response. BOTH doctors you quote (from 2005) suggest weight loss.
I was talking about "connecting the dots" and again, specifically to weight loss recommedations. The first doctor connected the dots by recommending gradual weight loss for overweight patients. Hmmm (sacrasm unecessarily added) Hmmmm (why not over do it) isn't that exactly what I said? Hmmmm
Second doctor you noted ALSO suggests weight loss and you speculate on whether or not he would recommend weight loss in overweight patients without fatty liver. He agrees with the first doctor so just because he might go for weight loss and metaformin with fatty liver biopsy does not mean he "only" does it in those cases.
---------
CO:
Realistically....how many people will loose weight if they're given no education?
--------------
Not sure what you mean by this. All I am saying is that weight loss has been suggested by good liver specialists for some time now, and that -- along with lifestyle changes such as exercise, stopping smoking, etc, -- rightly should be the first line attack for IR. This is not to criticize using drugs like Metaformin if first line measures do not work. And yes, a number of people here have lost signficant weight prior to treatment because their doctors told them to. "Gauf" is one example. When someone has something as serious as Hep C can be, and their doc tells them that losing weight will help SVR, that can be a real motivation.
_____________________________
Really? Let's see. Here's what a couple of hepatologists said in response to these questions back in Sept 2005.....
-----------------------
Yes, "really" MS sarcastic one these days.
Please read again my statement, and your response. BOTH doctors you quote (from 2005) suggest weight loss.
I was talking about "connecting the dots" and again, specifically to weight loss recommedations. The first doctor connected the dots by recommending gradual weight loss for overweight patients. Hmmm (sacrasm unecessarily added) Hmmmm (why not over do it) isn't that exactly what I said? Hmmmm
Second doctor you noted ALSO suggests weight loss and you speculate on whether or not he would recommend weight loss in overweight patients without fatty liver. He agrees with the first doctor so just because he might go for weight loss and metaformin with fatty liver biopsy does not mean he "only" does it in those cases.
---------
CO:
Realistically....how many people will loose weight if they're given no education?
--------------
Not sure what you mean by this. All I am saying is that weight loss has been suggested by good liver specialists for some time now, and that -- along with lifestyle changes such as exercise, stopping smoking, etc, -- rightly should be the first line attack for IR. This is not to criticize using drugs like Metaformin if first line measures do not work. And yes, a number of people here have lost signficant weight prior to treatment because their doctors told them to. "Gauf" is one example. When someone has something as serious as Hep C can be, and their doc tells them that losing weight will help SVR, that can be a real motivation.
Go get 'em CO!!
"That's right. The women did much better than the men."
____________________
High five sista!
Co
"That's right. The women did much better than the men."
____________________
High five sista!
Co
"I am curious have any studies been done if IR is a leading factor for Non Response to interferon treatment"
___________
It is now the MOST important host factor......
"Thus, insulin resistance emerges as THE MOST IMPORTANT host factor in the prediction of response in non-diabetic patients treated with the best available option -peginterferon plus ribavirin. Interestingly, insulin resistance has been found a common denominator to the majority of features associated with difficult-to-treat patients. Patients with cirrhosis, obesity, HIV coinfection and Afro-American showed all insulin resistance."
http://scielo.isciii.es/scielo.php?pid= ... ci_arttext
"of all the Non Responders How many are Insulin Resistant? From what I am reading seems Many?"
We don't know exactly. Most of the doctors do NOT test people with Hep C for insulin resistance. Even though we've known for years that insulin resistance lowers SVR. According to some of the studies, up to two thirds of Hep C patients have IR.
" Why after all these years of the Interferon treatment is this only now coming to light??"
(I've been asking that for years).
Because even though they knew that IR lowered SVR, they hadn't done any studies (until recently) using medications to lower the insulin resistance.
"Diabetics with Chronic HCV is that different than insulin resistant? Or are Diabetic conditions the same as Pre Diabetic"
First comes PRE-DIABETES (a fasting blood sugar above 100)....When you start becoming insensitive to insulin, your blood sugar starts to go up. A study showed that a blood sugar above 100 lowers SVR.
Then the insulin resistance gets worse.....and for a long time your pancreas works fast and makes extra insulin, so it's able to keep your blood sugar in the normal range even though you're insulin resistant..
But eventually, you become more insensitive to insulin and the pancreas can no longer keep working so fast.....slows down....sugar goes above 126....and you're now considered a diabetic.
So that means that you have to be insulin resistant before you can become a diabetic. All diabetics type 2 are insulin resistant.
"and do people with Diabetes on tx do they SVR "
I believe CS and I created a monster...LOL
Great question.
Years ago, I used to work with both diabetics and people with Hep C. And I noticed that many diabetics didn't clear. If their blood sugar was kept under very strict control they did better. But the problem is that treatment can also make the diabetes worse.
Don't stop asking.....
Co
___________
It is now the MOST important host factor......
"Thus, insulin resistance emerges as THE MOST IMPORTANT host factor in the prediction of response in non-diabetic patients treated with the best available option -peginterferon plus ribavirin. Interestingly, insulin resistance has been found a common denominator to the majority of features associated with difficult-to-treat patients. Patients with cirrhosis, obesity, HIV coinfection and Afro-American showed all insulin resistance."
http://scielo.isciii.es/scielo.php?pid= ... ci_arttext
"of all the Non Responders How many are Insulin Resistant? From what I am reading seems Many?"
We don't know exactly. Most of the doctors do NOT test people with Hep C for insulin resistance. Even though we've known for years that insulin resistance lowers SVR. According to some of the studies, up to two thirds of Hep C patients have IR.
" Why after all these years of the Interferon treatment is this only now coming to light??"
(I've been asking that for years).
Because even though they knew that IR lowered SVR, they hadn't done any studies (until recently) using medications to lower the insulin resistance.
"Diabetics with Chronic HCV is that different than insulin resistant? Or are Diabetic conditions the same as Pre Diabetic"
First comes PRE-DIABETES (a fasting blood sugar above 100)....When you start becoming insensitive to insulin, your blood sugar starts to go up. A study showed that a blood sugar above 100 lowers SVR.
Then the insulin resistance gets worse.....and for a long time your pancreas works fast and makes extra insulin, so it's able to keep your blood sugar in the normal range even though you're insulin resistant..
But eventually, you become more insensitive to insulin and the pancreas can no longer keep working so fast.....slows down....sugar goes above 126....and you're now considered a diabetic.
So that means that you have to be insulin resistant before you can become a diabetic. All diabetics type 2 are insulin resistant.
"and do people with Diabetes on tx do they SVR "
I believe CS and I created a monster...LOL
Great question.
Years ago, I used to work with both diabetics and people with Hep C. And I noticed that many diabetics didn't clear. If their blood sugar was kept under very strict control they did better. But the problem is that treatment can also make the diabetes worse.
Don't stop asking.....
Co
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