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Avatar universal

SVR or Relapse?

As more and more members are either reaching SVR or relapsing, I thought we could start a thread which allows those who have completed treatment to post their personal results. This may be helpful to others who will be starting treatment soon.

If you choose to participate, please follow this outline:

Gender:  
Ht/Wt:
Genotype:
VL at start:
What Treatment:
How Long:
SVR or Relapse:  
Comments:  (if any)



Feel free to suggest additional info.
Nan
Best Answer
Avatar universal
Gender: Male
Age: 59
Ht/Wt: 6' 220#
Genotype: 2b
VL at start: 125,000
What Treatment: Sovaldi/Ribavirin
How Long: 12 weeks
Date completed 04/22/14
SVR or Relapse: SVR
Liver Status:  F2-3 on biopsy 06/13 Fibroscan 10.2 kPa 07/14
Naive or Prior treatment:  Naive

Additional Comments:  
No side effects to speak of. I was able to XC ski regularly and cycle 200 mi+ a week while on treatment. Hemoglobin went as low as 13.9 but no anemia
257 Responses
Sort by: Helpful Oldest Newest
475555 tn?1469304339
Yup, UND at EOT+15 mos. Plus all liver functions intact by recent blood analysis. So things are steady-state and I'm finally able to relax about it. I don't like to count my chickens, though, so I will have VLs done every year, and of course continue the bi-annual color US to check for HCC, portal hypertension, etc. The reports on UND people's fibrosis continuing to advance (not many, but some) will keep me on watch the rest of my life.

Cheers, Sandi, and thanks for asking.

Mike
Helpful - 3
3 Comments
Congratulations Mike! You did it! I am so happy for you! You are now an official Dragonslayer!
Do I get a button?
You come to San Diego, you get a button!
475555 tn?1469304339
:-)
Helpful - 2
Avatar universal
Gender: Female
Age: 55
Ht/Wt: 5'11"/225
Genotype: 1A
VL at start: 775000
What Treatment: Harvoni/Ribavirin
How Long: 24 weeks
Date completed 8/25/15
SVR or Relapse: SVR 24 (finally!!!!!)
Liver Status:  Early cirrhosis
Naive or Prior treatment:  
3 previous treatments:  interferon 3 x week/Ribavirin 6 months 1999, boceprevir/interferon/Ribavirin 24 weeks 2012, Sovaldi/Interferon/Ribavirin 12 weeks 2014.
Additional Comments:   I am incredibly grateful and still can't believe the virus is dead!  The first two treatments were really rough. I'm so glad the cure for most is so much easier and has such better cure rates!

Positives: Having gone through Hep C and all that goes with it has taught me so much about courage, bravery, perseverance, faith, patience and trust.  I have met some incredible people.  Thanks to everyone on here who chased the dragon with me and for my spouse and all spouses who helped all of us with the fight.  I also offer up prayers and a moment of silence to all those who fought the fight and weren't able to receive this incredible gift that I have received. To those in the fight and those yet to fight, stay strong and slay that dragon!
Helpful - 2
317787 tn?1473358451
Thinking of you all, couldn't have gotten to SVR without all of you, much love, Dee
Helpful - 2
Avatar universal
When I started this thread 18 months ago, I was hoping to one day add my husband to the list as reaching SVR12.
Well, that day is finally here!!!!   Today is his 70th birthday and he just got his 12 Week post Harvoni treatment lab result - UNDETECTED!  
Gender:  Male
Ht/Wt:  5'10'' / 185 lbs
Genotype:   1B  (previously told he was 1A)
VL at start:  96,000
What Treatment: Harvoni  
How Long:   24 weeks
SVR or Relapse:  SVR12!
Comments:  (if any)
My husband is a liver transplant patient. He received his new liver in June, 2012.  Unfortunately due to recurrent Hep C, within 7 months, a biopsy showed he had cirrhosis of the new liver again. A six month treatment with Sovaldi and Ribavirin (low dose only) unfortunately failed. Three months later he had a bad fall and fractured his femus and humerus which delayed treatment with Harvoni for another six months. He finally started treatment in June, 2015 and completed treatment in November, 2015.  It was a very difficult year but he hung in there and now on his 70th birthday he got the news - it was all worth it  -  SVR12!
Hallelujah!  Praise God!
Helpful - 1
1 Comments
Praise God, indeed!  You and you husband have been an inspiration to so many of us.  So glad to hear your wonderful news.  nOw BOTH of you step up onto the Dias and receive his Dragon Slayer Supreme Insignia.  Boy, have you both earned it!!!!

Love and Blessings,  Pat
Avatar universal
Gender: M

Age: 60 at start of treatment in January, 61 now

Ht/Wt: 5'8" 195

Genotype:

3a also Stage 4 (cirrhosis)

VL at start:

5,000,000 +

What Treatment:

MK3682b (Grazoprevir, MK8408, MK3682) + ribivirin

How Long:

16 weeks

SVR or Relapse:  

SVR 24, received the news today!
Helpful - 1
1 Comments
Congratulations!
Avatar universal
In early January, I began a clinical trial for genotype 3, 16 weeks of MK-3682B plus ribivirin.

The drug MK-3682B consists of three drugs: MK-5172 (aka grazoprevir), MK-3682, and a newer drug MK-8408 (some are being given MK-8742 aka elbasvir).

Received good news this morning: SVR 12

Helpful - 1
Avatar universal
Last week I got my EOT + 15 month results and I'm still undetected. NOW I can breathe easy. The 24 week test for some reason felt like it was a dream and I really didn't consider myself out of the woods. Now that I have 2 undetected tests I'm starting to believe it. Liver functions are on point and all my labs are excellent though I will have to have yearly scans since I was Stage 3 at the start of this last treatment.
Helpful - 1
1 Comments
Congratulations on being cured!
7469840 tn?1409845836
Oh what wonderful news Nan! Wow you two have been through the wringer, but your persistance has finally paid off! What a great birthday and Valentine's Day gift!
Helpful - 1
Avatar universal
Gender:   Female
Age: 40 years old
Ht/Wt: 5'5'', 140lbs
Genotype: 1b
VL at start: 5,000,000 thereabouts
What Treatment: Harvoni
How Long: 24 Weeks
SVR or Relapse: SVR
Liver Status: Stage 3
Naive or Prior treatment:   Treatment experienced
Comments: I just got the call from my Hepatologist telling me that my 24 week post treatment HCV QUANT is undetected. It's surreal. My husband cried over the phone as this has consumed our lives for the entirety of our marriage. I found out on my honeymoon I had HCV.
I'm a 3 time null responder to Peg-Intron/Riba, Pegasys(daily shot)/Riba, Incivek/Riba/Peg-Intron. Was never undetected on any of these. Even with Harvoni, I didn't achieve undetected until week 10 which prompted me to demand a 12 week extension of Harvoni. Surprisingly, I didn't encounter much resistance from my insurance. Maybe because I called them every day to check the status.


Helpful - 0
1 Comments
Alright fantastic news congrats! I am also a 3 time null responder except I have cirrhosis just did my 24 week post treatment viral load test this week but was not detected at 12 weeks post. Way to bug the insurance company glad they let you go out to 24 weeks!
6708370 tn?1471490210
Gender:  F
Ht/Wt: 5'9"/140 lbs
Genotype: 1B
VL at start: 7 million
What Treatment: Sovaldi/Oylsio
How Long: 12 weeks
SVR or Relapse: Relapse
Liver Status:   Cirrhotic
Naive or Prior treatment: Naive before treatment  
Helpful - 0
Avatar universal
Gender:  F 40
Ht/Wt: 5'2"/110lbs
Genotype: 1b
VL at start: 515,000
Length of time since infection: 17 years
What Treatment: Sovaldi/Ledispavir/GS-9669 or GS-9451
How Long: 4 weeks
SVR or Relapse: Relapse on 12weeks
Liver Status:   no cirrhosis, no fibrosis
Naive or Prior treatment:   Naive

Helpful - 0
Avatar universal
Gender:   M
Ht/Wt: 68” / 165 lb
Genotype: 1a
VL at start: 7,216,000
What Treatment: Sovaldi + Olysio + ribavirin
How Long: 12 wks
SVR or Relapse: SVR
Liver Status:   non-cirrhotic
Naive or Prior treatment:   multiple prior
Helpful - 0
Avatar universal
Gender:  F
Ht/Wt:  6'0, 200 lb
Genotype:  1a
VL at start:  2,975,000
What treatment:Sovaldi/Ribavirin/Pegasys
How long:  12 weeks
SVR or Relapse: unknown.  One week post treatment VL Not Detected.
Liver status:   Early Cirrhosis
Naive or prior treatment:  3rd treatment.  2012-Victrelis/Ribavirin/Pegysys 24 weeks, had to stop 48 week treatment sue to never reaching undetected.  1999- Ribavirin and Interferon 3x a week for 24 weeks.  Didn't work.

Comments:  MD not doing next VL until 2/2015.  Hoping for SVR, but will continue the fight if need be.
Helpful - 0
Avatar universal

      
Gender.     Female
Ht/Wt.         5'3/110
Genotype.      2
VL at start.    352.  Only
Tx.     Sovaldi / Ribavirin
Duration.     12 weeks
SVR or Relapse.   SVR12.  Cured
Liver Status.   Early Cirrhosis
Naive or prior Tx.    Naive
Comments.   Completed Tx April 7, 2014
Meld score went from an 8 to a 6 after Tx
Helpful - 0
7469840 tn?1409845836
Gender: Female
Ht/Wt: 5' 6"/144 libs
Genotype: 4A
VL at start: 192,000 (4 months prior to treatment)
What Treatment: Sovaldi/Ribavirin/Interferon
(Ribavirin was reduced from 1,000 per day to 200 a day for 2 days after 2 days off [on days 25, 26,] brought up to 600 a day for the rest of 2nd third of Tx, raised to 800 a day for last third of Tx)
How Long: 12 weeks
SVR or Relapse: SVR12
Liver Status: Non-cirrhotic—but no biopsy. Ultrasound normal, enzyme levels low.  
Naive or Prior treatment: Naive
Helpful - 0
Avatar universal
Gender:  Female
Age:  59
Ht/Wt:  5'7"/155 lbs
Genotype:  1b
VL @ start:  5,070,000
Length of time since infection:  43yrs (Dx: 2012)
What Tx:  Sovaldi/Olysio
How Long:  12 wks
Date Started/Completed:  2/11 - 5/5/14
SRV or Relapse:  SVR-12
Liver Status:  Early Cirrhosis & Fatty Liver (Biopsy 3/18/13)
Naive or Prior Tx:  Naive

Had Favorable Variants, SNPs - C/C & T/T (IL28B)
Helpful - 0
Avatar universal
I went undetectable at about week 6 on O/S - I am a 1a Cirrhotic - compensated. I have 8 more days to go on the trial. Will keep you posted.
Helpful - 0
Avatar universal
I know I'm posting too early on this question, and I'll have to update it later, but I can't help myself!

Gender:  Female
Age:  53
Ht/Wt:  5'7"/138 lbs
Genotype:  1A  (prior tested as 1A/1B..1B cleared on one of my tx's)
VL @ start:  2,165,111
Length of time since infection:  30yrs 99% sure infected in 1983-tested positive for nonA/nonB in 1985, told it was 'no big deal'.., elevated LFT's with RUQ pain and Dr. ran the hepatitis panel in 1994-positive for C then.
What Tx:  Sovaldi/Pegasys/Ribavirin
How Long:  10 wks  treatment completes approx 09/15ish...)
Date Started/Completed:  6/18 - 09/15ish...I think of 2014
SRV or Relapse:  to be determined..., so far week 4 and week 8 are undetected.
Liver Status:  had 5 biopsies over the years. 2 of them had bridging fibrosis later stage 2/border 3.., then, with more treatment, biopsy improved and my liver is not a low stage 2, no bridging, but more steatosis
Naive or Prior Tx:  VERY treatment experienced!  This is my 11th attempt at treatment and until this treatment, have always been a null responder.  I ever was on Telaprevir/Incivek.  Did double dosing of Peg-Intron and and double dosing of Infergen.  At one point I was doing a doctor sponsored study of combining Actimmune with a Peg another time, I was on Thymosin and Peg.  Another time when I was on the double dosing on the Infergen, doctor all had me double dosing the Ribavirn.  It's amazing I did keal over on all these different regimens.  I was in several trials, one of which was the Telaprevir/Incivek w/ no Riba/just Peg.., that's the group I was randomized into.  These past few treatment have been about 3 yrs apart.  There was several years that that I was doing a long treatment, didn't clear and then, a few months later was trying something else.  I can't do that anymore. I've put my body through too much.  If I don't SVR on this one, I won't be jumping into a new treatment immediately.  Need recovery time.  Susan400
Helpful - 0
Avatar universal

nan535  
Aug 24, 2014
To: All
As per the responses received, please follow this updated outline.

Gender:  
Ht/Wt:
Genotype: 1b
VL at start: 409,000
What Treatment: Sovaldi a and olysio
How Long: 12 weeks
SVR or Relapse: SVR Cured
Liver Status:   2/3
Naive or Prior treatment:   Naive

Additional Comments:  43 years having hep c and many autoimmune disease
Now cured = yeah!
Helpful - 0
Avatar universal
Just want to keep this thread alive as I do think it will be helpful to others who
not only are starting treatment but those who have relapsed.

Nan
Helpful - 0
Avatar universal
Make 57
6'2 250

G2b
255k vl
Sovaldi /ribb
12 weeks
Relaspe second time iv relasped
Vl at 12 post tx 880k
Status good
Helpful - 0
317787 tn?1473358451
Gender:  Female
Ht/Wt:  5' 5" 140
Genotype: 1A
VL at start: first time 12 M, second 336K
What Treatment: Peb, Riba, Polymerase inhibitor  - Incivek, Peg, Riba
How Long: 43 wks  - 24 wks
SVR or Relapse:  Relapse  SVR now considered cured 2 years later
Comments:  Good idea Nan :)
Helpful - 0
7510956 tn?1411671417
Hello, like to know how you are doing regarding side effects from  Sovaldi and Olysio, thanks.
Helpful - 0
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