YAY! cEVR

[Juttutin]

So got my 12wks results today...  complete EVR at 12 wks (GT 3; end of tx; 7977+RBV; RVR at 3 wks) with NO Interferon.

Yay me - but way more than that, is the hope that others in my trial on zero IFN will get the same result (informally looking good so far amongst the sub-sample I or my cohortees communicate with) (and SVR of course) - and the corner will be turned with this nasty microbe - sooner rather than later - and those of you here who are caught debating whether to start treatment now or later (which I know is something many of us here have been through) will be saved that horrible ongoing stress, and the odds on the gamble get a whole lot better for you and a whole lot worse for the wee germy.

[willbb]

Juttutin&Dave.. Thx for that...missed the (0)  when I read it.

Again Juttutin...good luck!

[carol411]

Can't wait to read your SVR post!!  Tx without interferon!

[Juttutin]

Dave, exactly.

Searched up a very short article about the trial which touches on the background/motivation for it: http://www.newstatesman.com/healthcare-and-pharmaceuticals/2010/12/psi-7977-hcv-genotype-patients

[spectda]

From what I can understand ifn was either 0/4/8/12 wks and he was in the 0 interferon group. Is that correct juttutin.
-Dave

[willbb]

  
  I think I might be having one of my "not clued in days"  but I thought  your original post said there was no INF.in this trial and from what I see in the last post there is  Inf. for everyone,just at varying lengths of time.

If you could explain again,or if somene else can explain what I am missing I would appreciate it. :)

WILL

[Juttutin]

Thanks Will.

The 3wk sample (and all since) came back UND; I'm not 100% sure if the 3wk sample was the one taken on day 15, or the one taken on day 22 - I'm thinking day 15.

The treatment is 12wks for all participants (all are GT2/3) - just varying durations of IFN (0/4/8/12 wks). One person in my cohort went UND at 2 days (4 wks ifn) and is also UND at 12 wks (as are the other 3 from the first intake).  

[willbb]

  Just to expand on Daves question,,were you UND  at wk.4 or before(RVR)  and is that the reason for the treatment only being for 12 weeks total?

And  congrats by the way...a good result  !

WILL

[Juttutin]

... and thanks.

[Juttutin]

Dave, Hi.  Yes, your understanding is correct.    

My understanding re EVR is/was that EVR is defined at 12 weeks - and means either (pEVR) a >2log drop in load at week 12 of tx, or (cEVR) UND at week 12 of tx.

Total treatment time was 12 weeks, been off the meds for two weeks now - had my 14wk blood tests today.  The monitoring side goes on for 24 weeks after ending treatment.

And yes, just RBV and PSI-4977 (Also per Diane's Qn.)

[spectda]

I am confused by your use of the term evr at 12 weeks, that would normally mean that you first became undetectable at 12 weeks. Am I understanding that you were rvr at 3 weeks and you were still undetectable after 12 weeks of treatment? How long is total treatment time for you and what week are you currently in? Are you taking only ribavirin and psi-7977?

Good luck,  It would be great news if you svr without interferon.

- Dave

[Diane12855]

So what are you taking?

Diane

[Susan_1a_CC]

Sounds exciting.  Congratulations!