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Avatar universal

its baaaaaack

hello again, from my short lived freedom from disease.first i want to thank everyone for the awesome support i recieved on here i finished treatment for geno 2 in november.just recieved my 3 month bloodwork heres the results, i was und. from week 5 on.

ast 62h
alt 110h
hepitimax hcv rna 149858
"                "     "     5.18
all other bloodwork clear

would like suggestions on next step. my nurse ( who i love) told me she really was unsure of the next step.

                                 thanks Curt
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1707536 tn?1334974077
So very sorry to hear about your relapse; I can't imagine how frustrating it must be. ❤ ❤
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Avatar universal
thanks for the kind words and experiences.took some of the weight off.i told my dr i would like to hold off on any decisions for at least a year.
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1746242 tn?1318209702
So sorry I know those words cut like a knife:( I have heard them before. WE ARE LUCKY that so many new drugs are out there.
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Avatar universal
Sorry to hear about the relapse.  I am a two time non responder and know how tough it is to not get the cure.  I am a Geno 1a and don't know all that is available for Geno 2.  It sounds like there are some great possibilities in the pipeline so work closely with your doctor and take care of yourself, physically and spiritually.
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1856494 tn?1340542614
Really sorry about this set back.  So many of us have relapsed too.  You have a very good attitude and you have us.  And we have you.  Just wanted to add another candle to your darkness right now.  
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92903 tn?1309904711
I went looking and got close buy threw in the towel. See if you can search FLguy,s posts from June 2006 - that when he formed a very comprehensive retreatment plan. Or you might PM him.
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92903 tn?1309904711
Good on ya Big Daddy!

God damn I hate to hear relapse! Ribman - there have been other GT2s who retreated with 2-drug SOC and SVRed. Riba resistance, Insulin resistance, riba lead in zre all things to learn about. Suggest you look for posts from FLguy who it a text book case in retreating after GT2 relapse.
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1856046 tn?1330237245
So sorry to hear that  :o(

Many of us on here are relapsers and we can relate, 3 times for me and starting my 4th tx tomorrow. Maybe this time!

Like will says, take the best care of your liver and body that you can and try to keep your outlook positive.

The thing that helped me the most is going to the gym most every day. This surprised me because that is absolutely the last thing I EVER felt like doing. I was tough at first but I feel better for it than I have in many years. I have just started weight lifting too and am building back muscle mass that was wasting away. Maybe give that a shot or at least some mild physical activity each day. Yoga, prayer, and meditation have also helped me and those are much easier on your body too and helped me get over the relapses pretty quickly.

Like was said, although your tx didn't result in an SVR, your liver got a nice vacation. I have been cirrhotic for the 8 years that I have been diagnosed and have been mostly stable although my INR is creeping up a little.

And don't forget to live your life everyday!!!

New treatments are fast becoming a reality and hopefully we make it to see SVR and if not, we didn't take it lying down!

Peace Out,
Chris
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1148619 tn?1332010984
This broke my heart along with yours, I am sure. Sorry.

mo
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Avatar universal
Sorry to hear this ribman.  I hope you'll be able to to get in to see your hepatologist soon.  I don't know much about g2 either, but I would imagine your doc would want you to do an ultrasound or a CT scan and a biopsy to check to see if there's been progression of your liver damage.  I don't know what the next treatment options are for g2, but hopefully your doc can monitor you and keep you informed.
Advocate1955
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1986676 tn?1329862471
Sooooooooooooooo Sorry!!

Reva
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1794638 tn?1345155061
Oh Geeshhhh !   My heart is breaking for you.   I am geno type 1 A, and when I spoke to the GI and asked , " What If",   I go all through my treatment " UND" and then at my post 6 months Blood workups, come back .     He said I am done for now , until new treatment is available.   But again, I am a 1 A.   Not sure what the protocol is for 2.    
My Prayer for you is to keep the Faith and dont give up.  I will be praying for you.   Livinontheedge.          
P.S.    I am done with tx this saturday and will have my bloodwork done on Tuesday, so I am freaking too !  
Helpful - 0
Avatar universal
Sorry to hear the news.  The orals sound like they are in an early stage still.  Sounds like maybe you could afford to give your body a break for a year and see where treatment options are then.  Triple has worked for some genotype 2s.

http://hepatitiscnewdrugs.blogspot.com/2011/06/telaprevirincivek-isnt-useful-for-all.html
Helpful - 0
Avatar universal
Sorry for your bad news ,
Helpful - 0
Avatar universal
Add me to the list thats sorry to hear this, i agree the orals sound like you best bet....... Curious about your treatment since you were und at week 5 if you were able to stay on full course of meds throughout treatment? Best to you.
Helpful - 0
1669790 tn?1333662595
Sorry to hear this ribman, been following your posts for a while.  Give yourself some time to adjust and regroup.  I wish you the best for the next step.  Some of the orals do sound very promising for Geno 2's, so hope you have some options to consider.  
Helpful - 0
Avatar universal
fingers crossed and prayers everyday for all of us!!!!!
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Avatar universal
There is a 75-80% chance of success for type 2's so the odds are with us....
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Avatar universal
So sorry to hear its back, that really stinks! Now I'm really nervous, the anxiety of being so close and feel like I am holding my breath only to have the wind knocked out of your sails. I am geno 2 with f3-4 so i dont  have a lot of  options if this fails me at least you have minimal liver damage so you do have time. Good luck with what ever you and your dr. decide to do.
Helpful - 0
Avatar universal
Hey ribman.....sorry to hear this. I know exactly how it feels being in somewhat the same boat,however I feel the future is bright for folks in our position and glad to hear you still have only moderate liver fibrosis.

By the looks of it Incivek has been successful in trials for your genotype and possibly it will be approved for use in the future.

Other than that there are many new modalities being experimented with for all genotypes and the future does look bright for those of us that are waiting to treat again.

You may want to consider getting into a trial or just waiting it out while keeping a close eye on your level of fibrosis,while doing the best you can to keep your liver  as healthy as you can in the meantime.

Obviously no alcohol ,minimal amounts of any drugs  a healthy diet and weight management  if need be.
Have linked some info .below

Hang tough
Will

http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2011.02710.x/full



HCV genotype 2 treatment: PEG-IFN and ribavirin combination
Future therapies
Recently approved DAA inhibitors of HCV replication are expected to provide a major step forward in the treatment of HCV infection. Several small molecules, mainly inhibitors of HCV NS3/4A protease and NS5B polymerase are in the process of being commercialized in Europe.

Although DAA will improve virological response rates in patients with genotype 1, the development of small molecules effective against HCV genotypes other than one is in earlier stages [23]. Telaprevir, the first agent to directly target viral replication, has been shown to be active against HCV-2, but not against HCV-3. Telaprevir is a powerful oral protease inhibitor [24, 25] that can increase the SVR in genotype 1 HCV by about 30% compared to standard PEG-IFN/RBV. The activity of telaprevir was investigated in patients with HCV-2 and HCV-3 in the C209 study. The combination of telaprevir plus PEG-FN alpha-2a and RBV was evaluated in five patients with HCV-2 and compared to telaprevir alone in nine patients and to PEG-IFN and RBV in an additional nine patients in the control group. The triple combination therapy resulted in SVR rates of 100% which is remarkable considering the 89% rate observed in patients receiving standard PEG-IFN/RBV [26]. Conversely, telaprevir monotherapy had little or no activity in patients infected with HCV-3. In that study, telaprevir was administered as monotherapy or in combination with PEG-IFN for only 2 weeks, while the overall duration of treatment was 24 weeks in each arm. It should be noted that the histological diagnosis of cirrhosis was an exclusion criteria in this study.

Other NS3/4A protease inhibitors, nucleoside and non-nucleoside reverse replicase inhibitors as well as NS5A inhibitors have shown to have antiviral activity against HCV-2. One of the most promising drugs so far is PSI-7977, a nucleotide analogue polymerase inhibitor [27]. In the Proton study, an open label study, the drug was evaluated in 15 patients infected with HCV-2 and in 10 infected with HCV-3 as well as in a larger group of patients with HCV-1 infection [28]. That study, whose results were presented at the last EASL meeting, reported an RVR of 96% after the triple combination of 400 mg of PSI-7977 plus PEG-IFN/RBV. Twenty-four HCV-2 and -3 patients who completed the 12 weeks of treatment achieved SVR (96%). Patients with cirrhosis were excluded. The Electron study, an ongoing study, is currently evaluating this triple combination in an IFN sparing regimen strategy of only 8 weeks of triple combination treatment.

Helpful - 0
163305 tn?1333668571
Was the stage from a pre-tx biopsy?

Tx can help our liver even when one does not achieve SVR.
Often during the course of treatment while und, one's liver improves.
It can improve by a stage or more, meaning you possibly may have given yourself time to wait.
Of course the only way to tell the condition of your liver is to have another biopsy.

There have been amazing results in some trials with the new orals for geno 2 &3. I'd keep my eye on that option if I were you.
Helpful - 0
1815939 tn?1377991799
I am so very sorry to hear that the virus is back.

I really don't know what to tell you. I am still learning myself. Some other more knowledgeable members may respond and they may have some ideas, advice, data, information.

I surely hope the next treatment will work for you and perhaps it will be easier than these last two. I wish you the very best.
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Avatar universal
I'm so sorry you've gone all the way through treatment only to have the virus return.  I'm sure disappointed doesn't begin to explain how you're feeling. At the very least your liver had a good  break from the virus. I can't give you any advice on next steps, but an appointment with your hepatologist is definitely in order - I wouldn't expect the nurse to know what your next steps should be.   Are you in a position to wait for new meds to come to market?  Perhaps you would be a good candidate for one of the new studies, if any are available in your area.  Hoping the experts here will have some solid advice for you.  In the meantime I'm sending you cyber hugs.
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Avatar universal
sorry stage 2 grade 2
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