Are there any studies that show that the osteoporosis drug Evista affects the liver? Recently I came across a web health site that cautioned against taking Evista if one has liver disease. No further details (such as results of research studies) were provided. My wife has been diagnosed as having autoimmune hepatitis as well as osteoporsis. Fosamax (for osteoporosis) caused a ten-fold increase in liver ensyme levels, which returned to normal after stopping the drug. She is hesitant to start Evista if it may cause similar results.