yes, an overall 74% SVR rate for ILLUMINATE has been reported all along. However what Vertex never reported, and appears to have made less than glaringly obvious here, is what happened to the eRVR- subset - those who didn't go und by w4 and stay und at w12 (not a small group) among them, 78 of 118, 66%, got SVR.
many thanks for spotting that - Trin was obviously right. Table 19, on page 74, gives the answer. Hidden in plain view - Vertex must have been thinking we'd all enjoy an Easter egg hunt!
That 66%is likely to be important to many (about 40%) of naives starting triple tx : you get to w4 and are not und: do you push on? After 8 more weeks of selecting PI-resistant virions if you don't make SVR chances are you'll have a high proportion of them .
The FDA review did say, 'about 64%' so they're still right. Actually for all the grousing about incompetent government that review, IMO, was a great example of effective government service.
My calculations were 65 and 66 percent, but the willing's post stated FDA stated 'about 64%.'
Hey, what's 1% between drug companies, right? ;)
398/540=73.7%
Hasn't that always been the claim ?
What's wrong with the math ?
Table 19 gives the SVR rates of all four groups.
If you look carefully, the 2nd column of numbers under the 12+48 "eRVR-" shows that 8 out of 10 low VL were SVR; 70 of the 108 high VL were SVR (65%). Total SVR from that group of 118 was 78 (66%). Maybe the FDA is just lousy at math...?
Wow page 74 sure has some interesting stats. We sure our much better off with Tela !
Thanks for the post. I guess the bottom line is Tela is more effective than SOC. It does scare me when people call it a "cure".