Aa
Liver regeneration
Hi friends. I have early cirrhosis and have cleared my Hep C. Started Tx Jan 15 Sovd/Riba for 12 weeks and reached SVR12 in July. My meld score in Jan was 8, and 6 months later was 6. I'm due for my MRI Dec 30th
with results New Years Eve Day on the 31st. Yeah, it could be a good celebration for New Years, or maybe not.
Go to Mayo Clinic.
Have had no alcohol and have now been basically virus free for 1 year. My only sign of cirrhosis is small varacies and a nodular liver. Other then that feel pretty good. What prompted me to write this is I was reading some facts about cirrhosis on the FDA websight and something caught my attention. It said with cirrhosis, your liver can regenerate with up to 65% damage. It also mentioned that if they took 65% of your liver away thru surgery, it would still grow back and function normally. I found the premiss very interesting as how do we know what % of our liver is damaged.
I'm assuming there are no reliable tests which show extent of a scarred architecture.
Will it show regeneration with 1 year of non toxicity? For this I am hopeful, and is what I'm striving for also while engaging in healthy nutrition and working out. If damage is more then what is reversible, then I would imagine the
next route would be to hopefully stay in a maintenance mode.
We shall see.
Will give the heads-up in a few and the question may be answered. Am wishing that many of us whom are getting treatment, getting ready to, or done will see a reversal. Could also be to early to tell, but would think some kind of
change should be evident.
Holiday Wishes to all
.....Kim
with results New Years Eve Day on the 31st. Yeah, it could be a good celebration for New Years, or maybe not.
Go to Mayo Clinic.
Have had no alcohol and have now been basically virus free for 1 year. My only sign of cirrhosis is small varacies and a nodular liver. Other then that feel pretty good. What prompted me to write this is I was reading some facts about cirrhosis on the FDA websight and something caught my attention. It said with cirrhosis, your liver can regenerate with up to 65% damage. It also mentioned that if they took 65% of your liver away thru surgery, it would still grow back and function normally. I found the premiss very interesting as how do we know what % of our liver is damaged.
I'm assuming there are no reliable tests which show extent of a scarred architecture.
Will it show regeneration with 1 year of non toxicity? For this I am hopeful, and is what I'm striving for also while engaging in healthy nutrition and working out. If damage is more then what is reversible, then I would imagine the
next route would be to hopefully stay in a maintenance mode.
We shall see.
Will give the heads-up in a few and the question may be answered. Am wishing that many of us whom are getting treatment, getting ready to, or done will see a reversal. Could also be to early to tell, but would think some kind of
change should be evident.
Holiday Wishes to all
.....Kim
Hi friends and thanks for your support. TeeTom there is a big difference between F3 and Cirrhosis. Fibrosis is easier to recover from then Cirrhosis.
Since you have cleared the virus your liver hopefully will regenerate, although
you should abstain from alcohol as damage to your liver is already done.
I would think that you could likely move on with your life, but do believe a repeat check-up would be a good idea since its been almost 3 years. Would add, I'm not a Dr but personally if your following a healthy lifestyle you should be OK.
I'm sure others would disagree, and only my opinion. In my world, the less Drs and scans (unless needed) the better.
Good Luck
.....Kim
Since you have cleared the virus your liver hopefully will regenerate, although
you should abstain from alcohol as damage to your liver is already done.
I would think that you could likely move on with your life, but do believe a repeat check-up would be a good idea since its been almost 3 years. Would add, I'm not a Dr but personally if your following a healthy lifestyle you should be OK.
I'm sure others would disagree, and only my opinion. In my world, the less Drs and scans (unless needed) the better.
Good Luck
.....Kim
I have been SVR for 3+ years and I feel great. No side effects that I have noticed. I had stage 3 fibrosis and I haven't had a check up since my last report after a 1 year SVR. Is there a difference between fibrosis and Cirrhosis?
I guess I need to set up an appointment to get a checkup with the gastro.
I guess I need to set up an appointment to get a checkup with the gastro.
I am about 7 yrs SVR with early cirrhosis. Platelets hade I creased very gradually from pre TX 112 to now above 150. The most recent US suggested a slight increase in echogenicity, prompting me to start the Hep Tech protocol.
ps my ast and alt were normal for the first time in 20 some years!
it is a good feeling to see the results..
it is a good feeling to see the results..
thanks kim..so happy for you!
you offer us great info and encouragement. will keep checking in with you..
i has slight fibrosis 2? geno 1 eot Aug 14..
the docs said not to give up hope (pain syndrome started a few years ago) they said this is all new to them too..
so, maybe by this summer, with fresh air and warm sun i will really get better..i get shut in in the cold and snow..just can't go out as the pain starts bad with the cold weather.. and don't want to drive much on pain meds!
you offer us great info and encouragement. will keep checking in with you..
i has slight fibrosis 2? geno 1 eot Aug 14..
the docs said not to give up hope (pain syndrome started a few years ago) they said this is all new to them too..
so, maybe by this summer, with fresh air and warm sun i will really get better..i get shut in in the cold and snow..just can't go out as the pain starts bad with the cold weather.. and don't want to drive much on pain meds!
Forgot to add my Alkaline Phosphates went from 181 to a drop of 99 which is now in the normal range. That's the 1st time they have been normal since this entire adventure began. The Drs said this # is indicative of the Hepatitis inflammation now being absent. Would question that statement as of 4 months ago they were still high, even tho the virus had been eliminated 5 months or so prior.
All other lab work normal except for a high Hemoglobin.
Find that odd, as while on Riba my Hmg was in the gutter.
Have so much energy now don't know what to do with myself.
So in essence, if you have worries about your Hmg while on Riba it will rebound. That's a given!!!
Cheers
.....Kim
All other lab work normal except for a high Hemoglobin.
Find that odd, as while on Riba my Hmg was in the gutter.
Have so much energy now don't know what to do with myself.
So in essence, if you have worries about your Hmg while on Riba it will rebound. That's a given!!!
Cheers
.....Kim
Well the results are in. Just a recap, have been Hep C free from Jan 30, 2014 for geno 2, 12 weeks Riba/Sovaldi, early cirrhosis.
Had my 6 months post MRI and bloodwork.
Started Tx Jan 12, 2014 and deemed UND since Jan 30th.
SVR24. Cured as of Jan 1, 2015"
Meld score went from a 6 to a 7 but that was only by 1 tenth a %.
Platelets increased from 118 to 134
Cirrhosis is still evident with a nodular liver
Spleen, liver, gallbladder all within the normal range
Portal Hypertension 9mm if I'm correct
No ascites, He, tiny varacies
INR 1.1
Bili. 0.7
Creatinine 0.7
No liver lesions
I'm feeling great and have no residual effect from Tx.
Was kinda disappointed that the liver is still nodular, and was hoping that some smoother texture had been observed. It's my understanding that its takes 2 years for the platelets to return to normal, and hoping that will be the confirmation that the liver is indeed reversible.
Have been removed from the transplant list and am compensated.
Not sure if I'm outta the woods just yet, but continue to be optimistic that in time my cirrhotic liver will regenerate.
Would love to hear how others are progressing since reaching SVR.
This is relatively a new unknown territory with Tx that actually cures so many.
Will continue on this site to help guide the many newly fearful diagnosed, and for the seasoned pros just needing help and encouragement.
Wishing the best to all, and will post again my next 6 month results.
.....Kim
Had my 6 months post MRI and bloodwork.
Started Tx Jan 12, 2014 and deemed UND since Jan 30th.
SVR24. Cured as of Jan 1, 2015"
Meld score went from a 6 to a 7 but that was only by 1 tenth a %.
Platelets increased from 118 to 134
Cirrhosis is still evident with a nodular liver
Spleen, liver, gallbladder all within the normal range
Portal Hypertension 9mm if I'm correct
No ascites, He, tiny varacies
INR 1.1
Bili. 0.7
Creatinine 0.7
No liver lesions
I'm feeling great and have no residual effect from Tx.
Was kinda disappointed that the liver is still nodular, and was hoping that some smoother texture had been observed. It's my understanding that its takes 2 years for the platelets to return to normal, and hoping that will be the confirmation that the liver is indeed reversible.
Have been removed from the transplant list and am compensated.
Not sure if I'm outta the woods just yet, but continue to be optimistic that in time my cirrhotic liver will regenerate.
Would love to hear how others are progressing since reaching SVR.
This is relatively a new unknown territory with Tx that actually cures so many.
Will continue on this site to help guide the many newly fearful diagnosed, and for the seasoned pros just needing help and encouragement.
Wishing the best to all, and will post again my next 6 month results.
.....Kim
My bx revealed stage 3 fibrosis. I started Solvadi/Riba today for 12 weeks. GT 2. One of the questions I asked my doctor was will my liver post treatment completely heal to a 'normal' liver without fibrosis and he said YES. It takes about 2 years. Great news!!
You know I am going to follow this closely...please do post.....I have stage 4 ESLD decompensated....finished the sovaldi/riba.....my MELD had been 18 and now it is 10 and that is in two months....just had upper GI and per doctor have no varices. Blood work all looked could except for my platelets and am going to ask him how to deal with that since we aren't suppose to take iron....my count was really low at 79.
When I finished the sovaldi/riba it was like a 360....had slept for 6 months while on it...that's all I could do. So feeling good now but have been told just because I feel better doesn't mean I am. Still UND...waiting anxiously for the next blood test in 2 months...hope it gives me the SVR status I am hoping for. I was at the hospital a month ago and a lady who was in the same stage as I and decomp also did the sovaldi/riba and was taken off the transplant list as she is doing so well. I am still on the list but the head of surgery listed me inactive at this time and will watch my progress along with my hepatologist.
So.....you can see why I am reading these types of posts with interest.
When I finished the sovaldi/riba it was like a 360....had slept for 6 months while on it...that's all I could do. So feeling good now but have been told just because I feel better doesn't mean I am. Still UND...waiting anxiously for the next blood test in 2 months...hope it gives me the SVR status I am hoping for. I was at the hospital a month ago and a lady who was in the same stage as I and decomp also did the sovaldi/riba and was taken off the transplant list as she is doing so well. I am still on the list but the head of surgery listed me inactive at this time and will watch my progress along with my hepatologist.
So.....you can see why I am reading these types of posts with interest.
The key to what you said is "early cirrhosis". In that case there is not a lot of scar tissue so yes the rest of your liver will heal itself. And no there's not anything they can do with the scar tissue. It would be nice if they could go in and cut that part out and your liver then grew back like it does in a live liver TP. Keep in mind one doesn't need a 100% liver to live a long life without problems. Sounds like your doing all the right things. You should be fine... Best to you.
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