I have just been given the word that at week 12 on the Roche RO4588161 (R1626) Trial my log drop is 1.9. So close and yet so far. I will now switch straight over to subsidised SOC for 48 weeks. I am a little disappointed, however, from the outset it was pretty obvious with this 2b trail that I had drawn one of the short straws in terms of tx arms. I believe I was receiving 90ug PegINF - 1000mg riba - 1000mg PI but not certaiin. My chemistry and haematology remained rock solid throughout and currently my WBC, ANC, RBC Lymph, HGB are all comfortably within normal limits. My viral loads throughout went like bl - 4,480,000, w1 495,000, w2 307,000, w3 465,000, w4 59,000, w6 200,000, w8 133,000, w12 59,000. From the outset I was concerned with the 90ug PegINF dose that I believe I was on, however as you can see this to me is a riba issue. I began tx at 74kg and therefore 1kg underweight to receive 1200mg riba and got 1000mg. At about 4 weeks in I was 76kg and asked for the increase in riba but was advised that I had to stay on 1000 riba as per protocol (which I've been unable to reference). Anyway next week it is back for baseline bloods and SOC begins, I will be really interested in these blood results because I know for sure that I will have had 3 weeks of 1200 riba and full dose Peg and it will be interesting to see how this has effected my VL. I will not know what tx arm I was in until trial is finihsed at 96 weeks. So until then I'm not sure if I am a slow/non responder given my suspected dose. I have no regrets and still believe that R1626 will advance the svr rates. Some interesting travel stats for my 12 week adventure, 80 hours travel time, 6,000 kms travelled to reach clininc and back. To my trial buddies here, I wish you every success with the rest of the trial - good luck, I will stay in touch. Chat soon. Emi