Has anyone heard of thin glomerular basement disease?

[kyleauz1]

Hi
Has anyone heard os TGBM? Thin glomerular basement disease?
I am concerned about giving Alports syndrome to my sons..My nuephrologist said I wouldn't worry about it.
Evern though it was mentioned in my biopsy report, that people with TGBM can give it to their male offspring.

Thanks

[posie10]

My family has been genetically identified as having this disease
For complete information you should be aware
That the Univ of Utah and the univ of Minnesota
Have both been studying this disease. On males who
Inherit the mutation, there is almost. 100 percent they will
Need  a kidney transplant.  For females 15 percent because
The mutation is on the X chromosome and females
have two..  It can also affect hearing and more
rarely eyesight.  Hope this helps. Pursue a complete
medical evaluation.

[kyleauz1]

Oh yes I suffer migraines
Not really Hands but feet are not permantly swollen just on occassion.
My blood pressure is normal, which is good my Dr said.

[kyleauz1]

Hi,
I had a kidney biopsy actually was quite pain free felt only pressure.
It came back with TGBM (Inherited) & Glomerular hypertropy,due to early changes due to functional and structural adaptions.
My biopsy report came back 5 pages long, giving quite a bit of information about TGBM and the hypertrophy.
It Mentions TGBM disease can be associated with other nephropathies that may have chronic progressive course.
It mentions certain deformed genes can be associated with TGBM that can cause alports disease and only women are the carriers. They give to their male offspring such as progressive hearing loss to renal failure.
It says that they suggest that a repeated urinalisis on all available family members of this patient can suggest the type of inheritance and the most likely genetic basis of the disease . Such information is critical not only for genetic counselling but also for rendering  a probable prognosis in patients and familes with this type of basement membrane abnormalties.
My thickness of glomerular membrane is 180nm

Do you understand  this?
There are segmental irregular granular deposistion of IgM (++/4+) and C3 in the mesangial areas.
what is the (++/4+)?
There is a diffuse linear deposistion of albumin(++/4+),IgM(+/4+) , and IgG(++/4+) along all basement membranes.
What does that all mean?
I had no other blood tests done after the biopsy.
Now I understand protien in urine +++ as that was watched during my pregnancy.
Did your nuephrologist suggest further biopsies in the future? Mine did not say.
I was to go back once a year for a 24 hour urine test.

[snobaby1972]

i was told by my kidney doctor that i was born with it my doctor did'nt say anything about alports syndrome or giving it to my sons (i am female,) did your doc say you have iga nephropathy or high blood pressure,cause i have both as well and can be can be caused by tgbm, i also had biopsy last year,(exetremely painful) do you get alot of headaches and swelling in the feet ankles and hands?