Blood tests questionable

[Mist33]

So, for three years I have had a long list of medical problems that were supposedly unexplainable. My Dr for the last three years told me my blood tests were normal, that there was nothing out of the ordinary. Well, when he moved and I was out of a dr, i decided to do some more detailed research myself. Found out he was lying about my blood tests. There has not been a single normal test, he even avoided to tell me about the bulging discs he found in an MRI.
Symptoms: Neverending headache, low appetite, extreme fatigure, chronic diarrhea and nausea, joint pain, chest/abdominal pain that brings me to my knees, dizzy spells after everyday tasks such as grocery shopping, cleaning, five minutes in my garden- dizzy and everything turns red (ESP in the heat) and I usually eend up falling down. I have tingling and numbness in random parts of my body. Seizures (though we haven't been able to record an on EEGs. A different infection every week- no lie.

Last blood test I got was slightly worse than the others. Went to teh ER. I was constipated but my butt was leaking blood and mucus, the abdominal pains were frequent throughout the day and leaving me in tears. They said my tests all came back normal, no signs of infection. Sent me home saying I had diarrhea. here are my results:
ABS MONO 1.1   H  (RANGE .8-1.1 OVER LAST YEAR)
ABS POLY 12.5    H
BAND 2    L
LYMPH 13    L   (RANGE FROM 13- 21 GOING DOWN SLOWLY OVER LAST YEAR)
POLY 77    H
MCH 32.8    H    (USUALLY 32.SOMETHING)
WBC    15.9    H    (WAS 9.3 when i had orbital cellulitis a month before- supposedly cured...)
BILIRUBEN   1.7   H   (TESTS RANGE 1.7-2.7 OVER LAST YEAR)

[Ken_PA]

So then there is a mild single-parent ABL after all.

After you have a little time to decompress and celebrate, what you need is:

- an insightful treatment approach, which you can begin immediately while being aware of the expected time to onset of benefit
- a diagnosis for the remaining symptoms, which seem to be immune related and possibly associated with but not the same as ABL

[Mist33]

I was diagnosedWith ABL. They're doing more tests to see exactly how severe it is.  He said that explains the fatty liver and bilirubin. The rest he's not sure about. Sending me for a colonoscopy and to a GI. Those aren't until August though. He seems like agood Dr. Thought it was all very interesting.

[Ken_PA]

and one last thing: "clotting factors" are made in the liver. Being low in clotting factor proteins can lead to easy bleeding. They have names like Factor I, Factor VII, Factor X

[Ken_PA]

Ha, lookee here ( https://en.wikipedia.org/wiki/Acanthocyte ) :

"Acanthocytes arise from either of two mechanisms...  abetalipoproteinemia and liver dysfunction."

So let's choose the second option:

"In liver dysfunction, apolipoprotein A-II deficient lipoprotein accumulates in plasma causing increased cholesterol in RBCs. This causes abnormalities of membrane of RBC causing remodeling in spleen and formation of acanthocytes."

Which possibly leads to low HDL but normal LDL, and also the spleen is on the left side where you had that problem.

Btw, lipoproteins are generally made in the liver.

So now we are looking at *not* ABL. we are looking at liver dysfunction.

Or maybe a mild single-parent ABL causes fatty liver which causes the subsequent problems.

[Ken_PA]

Okay, but it's so rare that maybe it isn't well understood? It supposedly requires 2 parents... but maybe one side makes for a mild case with late onset?

I hate to give up in it, I guess.

"No deficiencies of any vitamins"
Vit E was tested for? Sometimes blood levels of nutrients are useless, one has to test in RBCs or otherwise.

"hdl cholesterol was low"
HDL has the alphalipoprotein (not the beta)

"Mostly just got sick really easy when they came in contact with anothr ill person. Poor circulation as well... "
Just like you.

"would there be any other abbreviations?"
Nope, just Vitamin K. (You might have heard of the famous blood thinner Warfarin/coumadin. That's a vit K inhibitor.)

"the liver thing"
the beta lipoproteins are necessary to carry fat out of the liver (aka "export"). I'd maybe avoid fructose for now if I were you.

"ascorbic acid.." is not fat soluble, but is good for the liver, as in hepatitis

" Is there a liver disorder that affects red blood cells?
Outside of getting rid of old RBCs and their bilirubin, I don't know.

" liver xray"
I'd think that was a sonogram since it mentioned 'echodense'. No?

------------

" rbc Is always low"
maybe because of the acanthocytes not being counted on an automated counter

From the cited article:
"Hematologic manifestations of ABL include acanthocytosis.
These abnormal shaped cells comprise 50% or more
of circulating erythrocytes and were among the earliest
laboratory features of the disorder (see Figure 1). Their
structure inhibits rouleaux formation, leading to
extremely low erythrocyte sedimentation rates. Anemia
has been reported in some cases of ABL [28]. "

I think you need a blood smear done. I'd push for that.

Yet how can you have ABL (which seems to be the official abbreviation) yet not have very low cholesterol levels...

Okay, I'll hear from you tomorrow then. Good luck.

[Mist33]

See , that's the weird part. No deficiencies of any vitamins or proteins. One time my hdl cholesterol was low. Supposed to b above 59 and it was at 45 mg. (8/30/14) . The EDS doesn't sound much like what I have.. the abeta could be a late show, though it's a long shot. See,the twothat had the more severe cases of a beta showed some symptoms earlier on. But my dad and the other were just skinny and had a few problems every now and then. Mostly just got sick really easy when they came in contact with anothr ill person. Poor circulation as well... Also both parents have to Carrythemutations. My mom was tested before we were born and she was negative.

I can't believe I never knew about the liver thing... As far as vitamin k goes, I can'tfind anything that says vitamin k on my records.. would there be any other abbreviations? I have noticed my sbscorbiic acid goes tonegative values then up to ten (ref .2-2). Straight to ten, then straight back down. Is there a liver disorder that affects red blood cells? I mean, liver xray,the blood levels, also my rbc Is always low.. this would really describe every single one of my symptoms....

Ok. Well. I'll do some more research. I feel like I understand this stuff better.