My history: liver transplant 1 year ago, had 2 moderate rejections and 1 mild since transplant. At present time having moderate rejection, recently had one portal stent and 8 Bilary ERCP's to remove stones and sludge and had stenting done, and at the present time there are no blockages. Was on Rapamune (5mg a day) prior to hernia surgery and then week before hernia surgery was put on Prograf (4mg a day) and taken off the Rapamune. I have been on Progaf since hernia surgery (8 weeks ago). Due to high billirubin reading of 28, I have been put on one Rapamune pill a day. I never had such a high reading prior to being put on Prograf, I'm going into hospital tomorrow for moderate rejection. Sine I'm on 4mg of Prograf and 1mg of Rapmune a day, could I be over medicated? Or could the Prograf that I've been on since hernia surgery be causeing high readings of billirubin and the moderate rejection?