Avatar universal

Two IgG bands positive... lyme?


I ordered my own lyme western blot test, and IgG p41 and p39 came back positive.  All other IgG, and all IgM negative.

Does that suggest lyme?  From what I understand, the p41 is positive in everybody, but the p39 is specific to lyme.
2 Responses
Avatar universal
I don't know that 41 is positive in everyone, but 39 is (from what I read) specific to Lyme, meaning only the presence of Lyme will give a positive on that band.

And note that not all home diagnostic kits are created the same ... so I would see a Lyme specialist without delay.  

Let us know what you find out, okay?  When it comes to Lyme, sooner is better.  All good wishes!
Avatar universal
PS -- I should also have added:

There is a newer, different test for Lyme, called a polymerase chain reaction [PCR] test that Lyme specialists often use in addition to the Western blot and ELISA tests.  

The Wblot/ELISA tests rely on your immune system reaction to determine whether you have a positive (+) test or a negative (-) test for Lyme.  Sounds solid, but it turns out that the Lyme bacteria can suppress your immune system, with the result that the Wblot/ELISA tests showing negative ('no Lyme infection') could be wrong, and you could indeed have Lyme.

There is a newer test called PCR, short for 'polymerase chain reaction'.  Instead of looking for your immune system's reaction (as ELISA/Western blot do), the PCR test looks for the direct presence of the Lyme bacteria's DNA.  The PCR test is far more accurate (so I read) than the (indirect) Wblot/ELISA tests.

Some (even many?) docs still use the older Wblot/ELISA tests, which are useful if they are positive ('you have Lyme'), but they are not reliable [so I read] if the tests are negative ('we don't see any evidence of Lyme.')

Having any positive reaction to the Lyme test you had would cause me to go straight to an MD who specializes in Lyme, but you may be comfortable your current non-LLMD doc.  Even if your current doc treats you with antibiotics, the doc may not approach the treatment like a Lyme doc would ... and that would for me indicate a huge difference.  Just a thought.  

All good wishes -- keep us posted on how you do, okay?
Have an Answer?

You are reading content posted in the Lyme Disease Community

Top Infectious Diseases Answerers
1415174 tn?1453243103
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Popular Resources
Fearing autism, many parents aren't vaccinating their kids. Can doctors reverse this dangerous trend?
Can HIV be transmitted through this sexual activity? Dr. Jose Gonzalez-Garcia answers this commonly-asked question.
A breakthrough study discovers how to reduce risk of HIV transmission by 95 percent.
Dr. Jose Gonzalez-Garcia provides insight to the most commonly asked question about the transfer of HIV between partners.
Before your drop a dime at the pharmacy, find out if these popular cold and flu home remedies are a wonder or a waste
Fend off colds and the flu with these disease-fighting foods