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Multisymptom Complexities.

Hello everyone. First time member and posting. Not certain where or which pages would be appropriate for my symptoms and advice. I'll be as brief in description with timeline as possible. Approx. 2 years ago, I developed a dry eye problem. After seeing an Ophthalmologist, he diagnosed me with Meibomian Disease. He indicated that its caused by an Autoimmune issue, but at that time I was not dx'd with an autoimmune disease. A year later I began having problems in both feet and calves. Bottom of feet would intermittently burn, tingle and actually hurt to walk. After 3 months of this pain, I saw a PA at a Neurologists office in which she tested me for Neuropathy and a few other autoimmune disorders. The skin biopsy returned as positive for Small Fiber Neuropathy. In current day its idiopathic. Additionally, in the last 6 months I've have horrible left arm pain and weakness. After having an Orthopedic Physician evaluate me, he indicated it was due to tight muscles but not sure what else may be a factor. He ordered a spine and head MRI which I won't have completed until next week. Oddly enough, in the last month I've developed a strange horizontal indentation / depression directly on my right side quadricep. I've not had an injury there past or present. Concerned, I underwent an MS-K Ultra sound last week and it came back as Atrophy of the subcutaneous soft tissue (?). Hence, waiting to schedule and appt. with an Orthopedic Physician for further eval. My concern is the rapidity of these symptoms that are surfacing. Of course, like many others, the symptoms draw us to the concern of MS. Which is why I'm here asking if anyone else has experienced these strange symptoms. Any insight would be wonderful if time permits. Thank you. Kem.
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987762 tn?1671273328
Hi and welcome,

Honestly from my understanding what youre describing could all be interconnected to what ever condition is causing the Small Fiber Neuropathy, Diabetes is the most common cause but there are others;
eg endocrine and metabolic disorders
metabolic syndrome
hereditary diseases
Fabry disease
hereditary amyloidosis
hereditary sensory autonomic neuropathy
Tangier disease
immune system disorders
celiac disease
Gullain-Barre syndrome
inflammatory bowel disease
mixed connective tissue disease
rheumatoid arthritis
Sjogren’s syndrome
infectious diseases
hepatitis C
Lyme disease
Other causes may include:

certain medications, such as chemotherapy drugs
vitamin B-12 deficiencies

Small fiber neuropathy is associated with the peripheral nervous system which are the nerves outside of the brain and spinal cord, where as neurological conditions like MS are associated with the central nervous system.

If you let me know what your MRI's turn up, i might be able to shed more light :D

Hope that helps......JJ
Helpful - 0
Thank you so very much for your reply. I never received anything in my email indicating someone commented on my post. Hence, the reason for the very tardy reply. To answer your question, the MRI came back normal with no acute or suspicious findings. The dent in my leg is something the Physician could not determine but indicated that PT would be the path forward. I completed my 4 month PT to rebuild the area and it is mostly gone. With all that stated, I now have another horrid ailment. I just posted on the Liver Abnormalities page. If it isn't one thing it's another. It's been a trying and exhaustive 12 months. Look forward to your insight. Again, profuse apologies as I should have logged back onto this site instead of relying on my email notifications. Thank you in kind for your time. OX
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