Research

[PastorDan]

I am always getting stuff in my Inbox that I didn't request, don't want, or can't fully grasp.  Has MedHelp ever decided that we should be able to post links?  If so, here's the most recent example of the third type.

http://www.msimmunology.com/b-and-t-cells-and-the-immune-system#cell?cid=ocr_DI_MNOCMSH0062_1&c=MNOCMSH0062

I am wondering if any among you fine friends can discern anything useful therein.

Peace and blessings to all!

[supermum_ms]

Hey there Pastor Dan long time no hear :D

Glad to see you up on the boards this morning, um didn't expect there to be homework before my first cup of coffee lol i've not got the brain cells up yet, so far the most interesting thing i've noticed on the site was...

"Academic research comparing total lesion detection rates of 7‑ and 3‑T MRI revealed 34% more juxtacortical lesions with 7‑T MRI that would have otherwise gone undetected."

"In an MRI study that included 380 MS patients, grey matter lesions were observed at clinical onset and were found in 64% of RRMS patients versus 0% in the healthy control group."

http://www.msimmunology.com/multiple-sclerosis-subclinical-clinical-disease-activity?cid=ocr_DI_MNOCMSH0062_1&c=MNOCMSH0062

We already knew there was approximately 25% more lesions detected on a 3T in comparison to a 1.5T and whilst I realise that 7T's are not available outside research purposes but missing 34%, is a lot....

Until the last couple of years, MS was basically thought to be a white matter disease, and it was a long term thought that grey matter was not significantly affected in MS, but research over the last few years is making it very clear that there are abnormalities in grey matter in pwMS. Gray matter may even become part of the diagnostic picture in MS, gray matter is a lot more difficult to see using current standard MRI techniques, atrophy can sometimes be found but recent developments in MRI techniques are picking it up ie diffusion orientational complexity (DOC).

I've now fried my last few remaining brain cells lol that's all i've got with this pea brain of mine, hope it helps :D

Cheers..........JJ    

[Corriel]

Hi PD! It's lovely to see you again.

Thanks for sharing the info. I will put it next on my "to review" list.

I hope you are doing well,

Corrie

[essdipity]

Hey there, PD! Long time no hear from you. I hope things are going well.

I'm not a good one to comment about blood cells and MS, not being very knowledgeable in that area, but as far as I can tell this info is accurate. Keep in mind, though, that it's from Genentech, which is of course a drug manufacturer, and like all the others, doesn't post anything just as a public service.

If you have something specific you're wondering about, perhaps someone else among our relatively tiny remaining membership can weigh in.