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spinal tap results confusion

1.The patient's CSF contains multiple restriction bands that
are also present in the patient's corresponding serum
sample. We are unable to define whether these
gammaglobulins are of systemic or intracerebral origin.
2.the OLIGOCLONAL BANDS, were absent.
3.The IgG Synthesis rate, CSF and IgG index, CSF are two
formulae for estimating the amount of IgG produced in the
central nervous system. Evidence of increased synthesis of
IgG provides support for the diagnosis of multiple
sclerosis. my albumin was high.
4.Cerebral Spinal Fluid:
No malignant cells
Rare small, mature lymphocyte. everything else so far was normal.  but MRI says-Reported mildly enlarge Pituitary Gland without a discrete mass seen within the anterior Pituitary Gland. No mass-effect upon the Optic Chiasm. Infundibulum is short and mildly thickened. Later MRI of the Brain was completed and reported multiple periventricular white matter  abnormalities.  Of significance was the presence of a large plaque in the left posterior frontal- parietal region, periventricular.  please help me understand this jargon.
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987762 tn?1331027953
COMMUNITY LEADER
Hi and sorry its taken me so long to respond to your question, although this is unlikely to clear anthing up or give you much if any insight beyond what you've already come up with....

You mentioned in your LP results that your albumin was high, the following might help explain meaning of it:

"Higher than normal levels of albumin may indicate dehydration or severe diarrhea. If your albumin levels are not in the normal range, it doesn't necessarily mean you have a medical condition needing treatment. Certain drugs, including steroids, insulin, and hormones, can raise albumin levels.30 July 2020

Albumin Blood Test: MedlinePlus Medical Testhttps://medlineplus.gov › Medical Tests"

You've mentioned things that aren't MS related so i'd be going out on a limb trying to make sense of it......i honestly think you should speak to your family doctor about these types of results, something is going on that's not normal but it may be something you were born with or developed over time so having someone with a medical degree explain what this means specifically for you is only going to be in your best interest.

sorry i couldn't be of more help.....JJ
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4 Comments
yes my albumin was high, but albumin CSF was normal. I saw my neuro since this post and he wants to do another MRI in 6 mos to compare. He showed me the white matter lesions on brain that are scattered and the huge one he saw. He told me since I have multiple restriction bands in BOTH CSF and blood that it could be something else and not MS, but that he isnt ruling out MS. He said most MS patients have that in CSF and not blood, but told me again that I have that in both of them.
My IGG syn rate CSF and myelin protein was below normal, but he said that doesn't contribute to MS.  He didnt want to give me meds or do anything based on his uncertainty so we agreed to do another MRI in 6 mos.
also, my endo has ran labs on growth hormone, insulin like growth factor, TSH, T4 free, prolactin, Testosterone total free, LH, FSH, estradiol, ACTH, DHEA-sulfate, 1- hydroxyprogesterone, AMH, cortisol, and creatinine. everything was normal except creatinine was slightly low.  Today my endo told me my pit gland is working perfectly and shows normal function. Also stated no signs of excessive cortisol production and that he ruled out any signs of ovarian and adrenal tumors.

on the neuro end, they ran VDRL CSF and it was negative. glucose, protein CSF. CSF cell diff count, culture CSF, and PT-INR were all normal.
I've known something was wrong , I just couldn't get anyone to look or dig deeper. So I am hoping to find out more in 6 mos.

I also want to note that I have redness on face like a butterfly imprint- AKA signs of lupus.  I am also positive for DVRRT- lupus anticoagulant, high protein C and MTHFR.
you said something about there were things that weren't MS related. like what do you mean?
re not MS related: "Rare small, mature lymphocyte. everything else so far was normal.  but MRI says-Reported mildly enlarge Pituitary Gland without a discrete mass seen within the anterior Pituitary Gland"
From my understanding of what you've mentioned, the neurologist you've been seeing wouldn't have anywhere near enough MS consistent diagnostic evidence to be able to diagnose a neurological condition like MS.

"multiple restriction bands in BOTH CSF and blood" rule each other out and equal normal, its when there are 2+ unigue Obands left over that the results are more suggestive of a neurological condition like MS. As your neuro mentioned though, not having MS consistent Obands soesn't rule out a neurological condition like MS so it will stay on your potential diagnosis list unless something else becomes your more likely diagnosis based on the totality of your diagnostic evidence and symptom pattern.

Totally recommend you stay open minded and not focus too much on any specific medical condition until you've gone through all the testing because it could turn out to be something completely different and not neurological in origin at all, eg Lupus


i cant help you with meaning in regards to MS diagnostic evidence because you haven't actually provided anything MS-ish to provide you with related information, scattered white matter lesions are basically not enough information because they're really common, you might be able to read your brain MRI report to work out where the lesions are located, lesion size, lesion shape etc potentially all those details are in the conclusion section.

Cheers.......JJ  
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