862732 tn?1254824857


49 year old female. DX's with MS in 2000. On Avonex ever since along with a LOT of other "symptom management" medications.

Recent blood test showing VERY high positive ANA SCR, ANA TITER 1:640, PATTERN SPECKLED.

GP is looking for "another reason" for my fatigue...UMM, BESIDES MY MS?? I THINK HE THINKS I'M OUT OF MY MIND?

QUESTION:  Could this have been "my norm" nine years ago or perhaps something I've just developed? I've moved so I don't have my complete records (something to think about getting, I suppose.) IF I was tested way back then...

Supporting tests and lack of other apparent symptoms rules out obvious suggestions / ideas...

Along with a variety of meds, I am on Synthroid (0.1 MG) and and Topamax (300MG). Before I see another specialist, I'm looking around on my own.

8 Responses
862732 tn?1254824857
Just to follow-up on this ANA test...

I spoke to my neuro's office yesterday after they reviewed the results of my blood test. As a refresher, the test was ordered by my GP, not my neuro. GP recommended that I see a rheumatologist, etc...

Neuro was as confused, as I was, in regards to [all the concern] and assured me that this type of result (see post above) is VERY OFTEN seen in patients like me, with MS (just as I suspected) ...

I have an appointment with him next week but see no reason I should be "re-diagnosed" for MS which, I believe, is where all this was heading! D'oh!!

Looks like this time it really IS one for the MS bucket.

[Duplicate post on another forum to close out discussion.]
Avatar universal
Wow...I'm having EXACTLY the same experience. My general practitioner wants me to go back to the rheumotologist because of a high ANA titer. I started here and then they decided it was ms after 2 years of testing. Its like I'm back to square one. Is it possible to have lupus and ms at the same time?
Avatar universal
I started with gp in Jan of 09 with the symtoms of pain in body and the blood test were on. after many blood test with a ANA of 1:1280 Speckled.  Sent to rheumotologist and no ansewers from him.  Finally sent to nurologist after talking my GP into sending me and had a EMG and a small nerve biopsy, have found no ans to the high ANA ( if any body else has an reason for the high ANA that would be helpful, with all other blood test neg).  Just thought that with the symptoms of fatigue and the ANA you might check out the EMG to start ruling out small fiber nuropothy.
Avatar universal
My 4 y/o daughter had blood work come back with an ANA titer of 1:640 and we are scared to death of what this means for the future of a beautiful, healthy girl.  The second test came back with lower numbers but the specialists are still concerned.  How common is this in young children?  She shows no signs except for not being able to control her blatter functions and is back in a pull-up.  H-E-L-P!!!!!!!!!!!
Avatar universal
My daughter is 8yrs old and having ana titer up and down up and down..up to 1:640,down to 1:340 or 1:160...i need an answer to why and what cause this?? anyone?? help me??
Avatar universal
Can anyone offer any advice?  It appears I may have Lyme and Lupus??  What should I be doing to resolve this issue?  Bloodwork details...Last Nov. Western Blot IgM 41, 39, & 23. Then allergy to Enalapril HCTZ major rash for 3 months (June-August) and now just blue skin.  June RDW 15.1, IgG >8, Chlamydia pneumoniae IgG Ab>1:256, Rocky Mtn IgM 2.53, CD57 Low.  July Anti SS-A >8.  Sept. DNA Single mutation in MTHFR A1298C and Sjogren's Anti SS-A >8.  October 15: ANA 1:640, pos Ro Antibody SS-A biopsy immunological presence and interfasce dermatititis.  Then October 29 Low C4 6mg/dl, ANA Positive, Anti-Nuclear AB Titer 1:320, ANA pattern speckled, SS-A Antibody >8.0 AI, Lekocyte Esterase 1+.    Thanks for any help.
Avatar universal
ANTI-dsDNA Reference range IU / ML
                     NEGATIVE     25    
Avatar universal
Perhaps your doctor should check for Autoimmune hepatitis...
Have an Answer?

You are reading content posted in the Neurology Community

Top Neurology Answerers
620923 tn?1452915648
Allentown, PA
5265383 tn?1483808356
1756321 tn?1547095325
Queensland, Australia
1780921 tn?1499301793
Queen Creek, AZ
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Popular Resources
Find out how beta-blocker eye drops show promising results for acute migraine relief.
In this special Missouri Medicine report, doctors examine advances in diagnosis and treatment of this devastating and costly neurodegenerative disease.
Here are 12 simple – and fun! – ways to boost your brainpower.
Discover some of the causes of dizziness and how to treat it.
Discover the common causes of headaches and how to treat headache pain.
Two of the largest studies on Alzheimer’s have yielded new clues about the disease