It has been 2 and a half weeks since I stopped all my B6 supplements, my level was 189.2 (2-21.2 norrnal). I have been suffering for 6 months, seen several specialists, been through several tests, MRI's, EMG/NCV, blood tests and so on. No one did a B6 level, so I began to do some research and found out that B6 toxicity could be causing my tingling extremities, nerve tickling, muscle twitching symptoms. I then requested that my physician draw the level and it came back toxic. I was wondering how long it takes to see some change, if even for an hour or so. I'm currently going to acupuncture weekly in hopes to get some relief. Can anyone help me?