Psoriasis & Psoriatic Arthritis Community
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1272624 tn?1395434357

My dh is 50 and suffering

Hi, I'm new to this forum, my husband just turned 50 and we just had our beautiful baby girl 8 months ago. He's on methotrexate but seems like he has no real relief. I want to support him but I don't know how to help!
Thanks so
2 Responses
1272624 tn?1395434357
Oh btw he's has psoriatic arthritis
4113881 tn?1415850276
"He's on methotrexate but seems like he has no real relief."

I believe that is a common thing. I have PsA as well but have never tried Methotrexate because my doctor said that there is a big question mark whether Methotrexate really helps the arthritic aspect pf PsA. It has shown good results for Psoriasis by itself but mixed results for PsA as a whole.

Has your husband considered Humira or Enbrel? Those are both proven drugs and they are less harmful on the liver. Below I will post a study regarding Methotrexate and PsA.

"Use of Methotrexate Questioned for Psoriatic Arthritis"

Methotrexate – a disease-modifying antirheumatic drug – is considered a first-line treatment for psoriatic arthritis, or PsA, but a British study raises questions about whether it actually does anything to slow down the disease.

The study, published in 2012 in the journal Rheumatology, is the first large, double-blind, placebo-controlled study of methotrexate for psoriatic arthritis. This study design means half the subjects received methotrexate and half received placebo – and neither the study subjects nor the researchers knew who was getting which medication. This kind of study design is widely considered “the gold standard” because it eliminates bias.

A total of 221 PsA patients were recruited from 22 specialty rheumatology clinics in the U.K. For six months, the subjects received either methotrexate, with a target dose of 15 milligrams per week, or a placebo. Various measures of effectiveness were tallied at three and six months. These measures included the PsA response criteria, or PsARC, which looks at the number of tender and swollen joints, as well as patient and physician assessments of disease progress; the disease activity score for 28 joints, or DAS-28, which assess tenderness and swelling in 28 joints; as well as blood tests that measure inflammation. Seventy of the subjects either dropped out or were lost to follow-up.

After six months, the researchers found methotrexate had no significant effect on objective measures of disease activity. But it did seem to offer subjective benefits for some – that is, doctors and patients seemed to agree the drug was beneficial based on doctor observation and how the patients reported they felt.

Bernard Rubin, DO, division head for rheumatology at the Henry Ford Hospital in Detroit, says that’s not an unimportant consideration. “Do many patients on methotrexate feel better? My perception is they do. There are a lot of measures of patient global well-being. If the patient feels better, that is one of your outcomes,” says Dr. Rubin, who was not involved in the study.


I really hope your husband kind find some relief....I know how it is to live with PsA.

God Bless
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