-The MAO-A in the brain can be influenced.
-Sirtuins are MAO-A modulators.
-SIRT1 activates MAO-A and decreases serotonin via deacetylation of NHLH2
Source: https://doi.org/10.1016/j.cell.2011.10.054
Suggestions for addressing Low MAO-A, modulating adrenaline levels and reducing inflammation.
1. Optimize SIRT1 levels.
2. Normalize circardian rhythm.
3. Exercise daily but before 7 pm
4. Take ample sun (to increase Vit. D and Nitric Oxide)
5. . Nicotinamide adenine dinucleotide (NAD+) is a necessary co-enzyme for SIRT1 to work
6. Highest quality possible of B complex (containing Methyfolate and Methylocobalamin B12)
7. DHA & EPA Omega-3s from Krill oil.
8. Eliminate all junk food & pro-inflammatory cooking oils Use coconut oil which does not degrade with heat.
9. Reduce carbs (anything with sugar, grains, flours etc.
is pro-inflammatory)
10. Increase cellular levels of magnesium.
Magnesium modulates cellular events involved in inflammation
Magnesium chloride (oral and transdermal) is the best source.
Best wishes,
Niko