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Anyone tried low dose Naltrexone for RLS

I would like to ask the group if anyone has tried Low Dose Naltrexone for Restless Leg Syndrome.   I haven’t taken it myself as my RLS seems under control at the moment - I have done a lot of research and it seems extremely safe and there are many people saying that it has worked extremely well for them.
A little background on LDN (Low dose Naltrexone). Naltrexone is a class of drug known as an opiate antagonist. Its normal use is in treating addiction to opiate drugs such as heroin or morphine. The dose used for this purpose is usually between 50 and 300mg daily.  However low dose usage is only 0.5mg to 1.5mg.  It is therefore extremely safe and has not been found to be addictive or cause augmentation.  The LDN works by briefly blocking the endorphin receptors of the body, usually at night for a few hours.  In response the body  results in a reactive increase in the production of endorphins, which should result in a reduction of painful symptoms and an increased sense of wellbeing. A lack of endorphins is linked to RLS.
Increased levels of endorphins should be expected to stimulate the immune system, promoting an increase in the number of T lymphocytes. This effect was observed in Dr Bihari's research. This increase in T-cell numbers apparently restores a more normal balance of the T-cells such that the effects of the disease process are significantly reduced.

Low Dose Naltrexone (LDN) may well be the most important therapeutic breakthrough in over fifty years. It provides a new, safe and inexpensive method of medical treatment by mobilizing the natural defenses of one’s own immune system.




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I researched this year's ago but couldn't take it due to being on opioids. I don't remember why I was so interested, but it was thought to help with one of my serious conditions - perhaps MS. I'll look into it again, because I'm currently coming off the narcotics - tolerance has made them useless. It's not easy to get off of them, but we'll worth it. They just no longer help me. I'd have to use such high doses that it would be too dangerous.

I'm glad you brought it up though, and I will be looking into it. I do remember that the research was very impressive and encouraging for multiple conditions.
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