What do these test results mean?

[missouriangel]

I'm 28, with a Heterogeous hypervascular solid cold lesion within inferior lower pole, slight asymmetrical enlargement of left lobe of thyroid gland as well as the presence of an area of photopenia within the inferior pole of the left lobe of the thyroid gland 2.5x2.0x2.3cm. Symptoms: excessive weight gain, energy loss, hair loss, joint/muscle pain, migraines, numbness/painful tingling on right side, motion sickness, dizziness, fainting/seizures, nausia, blurred tunneled doubled vision with bright flashes of light, can't smell, anxiety, heavy menstral cycles w/ blood clots up to 1 1/2", moodiness/irretability, forgetfulness, Low blood pressure, Low body temp
Test Results:
FNA, negative for malignancy. Thyroid uptake revealed 12% which is lower limits of normal. (normal 24 hour uptake 10-33%) TSH 0.39, Thyroxine 5.3, Bun 8, Carbon Dioxide 17.6, Potassium 3.4, Sodium 137, WBC 17.9, PLT 468, Neut%83.8, Lymph%12.3, Mono%3.7, Neut#15.0, Neutophils 84, Lymphocytes 6, Variant Lymph 4, Momocytes 6.
D-DIMER SCREEN POSITIVE (b) H     Notes: (b) D-DIMER Screening Assay
Elevated levels of D-Dimer are an indication of active fibrinolysis and have been found in patients with disseminated intravascular coagulation (DIC), deep vein thrombosis (DVT), and pulmonary embolism (PE). A POSITIVE result is obtained with this assay when D-DIMER levels are greater than 80ng/mL. This assay has a reported sensitivity of 89% for the diagnosis of DVT with a negative predictive value of 95%.
Do I have symptoms and signs of a certain type of disorder like Hashi, or something specific? Please help!

[Mark Lupo, M.D.]

The thyroid hormone levels are normal (TSH and T4) and thyroid uptake of 12% is non-diagnostic in this setting.  Was the FNA an adequate (satisfactory) sample or not.  Sometimes there aren't many thyroid cells, but a pathologist will still say "negative for malignancy" -- a cold hypervascular nodule is more suspicious for cancer and sometimes hypervascular nodules give more blood than thyroid cells...

D-Dimer tests are for blood clots-- ask your doctor about the significance of your test.

With your normal TSH, the generalized symptoms are not likely thyroid - but thyroid levles should be retested in 3-4 months to make sure they stay normal

[estrelinha]

I  haven't seen anywhere that can be hereditary, that's why it is so rare, but It is a genetic problem of the cell, when it grows (but starts with an healthy cell). Tomorrow I can ask someone that knows more about this genetic events.

[missouriangel]

I know that it is very rare, but there have been 2 cases of it in my family. I'm just wondering if it is genetic and if myself or any of my other family members are maybe at risk for it. Have you seen anywhere that it is genetic or reaccurent in families? I've read alot of sites and see genetic in all of them but don't understand if it is saying it is genetic through the family genes and others are likely to get it or if it is genetic as we just carry it.

[estrelinha]

Patients with rare genetic conditions called hereditary multiple exostoses (HME) and Maffucci’s syndrome can also develop a chondrosarcoma.
I took this from a web site:
"Why does mesenchymal chondrosarcoma occur?"

"Cancer arises in cells that have undergone several genetic mutations that cause their growth to become abnormal.  In healthy cells, complex molecular mechanisms prevent cells from growing when they are not supposed to grow.  It is thought that a series of genetic events occur wherein these molecular mechanisms are thrown off. The initial genetic event probably does not cause the cancer in its full-blown form, but rather throws the cell off-guard enough so that it will be certain to develop further genetic mutations and turn into a malignant tumor.  The entire sequence of genetic changes in the cell are unknown for most cancers, including sarcomas.  For some tumors, translocations are important in the early development of the tumor (Hanahan). Translocations are events in which one piece of a chromosome breaks off and becomes stuck to another chromosome.  This disrupts genes, turning off important “anti-growth” or tumor suppressor genes in some cases and turning on important “pro-growth” genes, also called oncogenes, in other cases.  Regardless of what the initial event is that leads to mesenchymal chondrosarcoma, there are no studies that have demonstrated why a patient suffers such an “initial” event and no investigators have been able to uncover whether there are any risk factors that increase a person’s risk for developing this rare tumor (Weis)."  

It is so rare that I don't think you should be worried.

[missouriangel]

Oh, also my 9 year old nephew died of a cancer 2 years ago called Mesenchymal Chordrosarcoma. This was a rare cancer found in people 60 - 70yrs old. I think it was tumors of the carilige and bone? It is a genetic cancer. Is there any chance I could have that? I think that is one of my fears, but a question I have been avoiding.
I am having my Free T3 and T4 and TSH levels checked again and will have those results in the next 48 hours due to the possibility of my illness affecting my levels before. I will let you know. Thank you.

[missouriangel]

01/16/08
1st FNA -Negative for atypia or malignancy. Very rare benign follicular cells, colloid and blood present.
Comment: Given the lack of follicular cells, this specimen is most likely not representative of the lesion. Clinical correlation is recommended.

What does it mean by very rare benign follicular cells, colloid and blood present? The nodule is cold, can it turn cancerous?

The procedure was repeated 06/20/08
Satisfactory for interpretation.
FEW FOLLICULAR CELLSMACROPHAGES, WBC'S, AND RBC'S PRESENT SMALL AMOUNT OF COLLOID PRESENT SUGGESTIVE OF THYROIDITIS
Negative for malignancy.

I recently switched Dr.'s. I'm very happy with my new one - he is an internal medicine Dr. He hasn't given me any type of thyroid meds or done anything about my nodule yet. He is taking car of some other heath problems I am having. I'm working the poor guy to death as I have been very sick. I was just wondering what you think, and if you could tell me if this has anything to do with my weight gain?