I tell patients to avoid adrenal extract -- it is imprecise, inconsistent and potentially harmful in terms of taking steroids that may blunt your own pituitary-adrenal axis. Licorice can cause hypertension in certain patients, again not recommended. Low dose DHEA (ie up to 50mg/day) has not been rigorously studied with the exception of an article in NEJM last week showing no benefit in patients >60yo with low levels of DHEA.
"Adrenal Support" with no hormones are not likely helpful, but I typically don't see a harm (unless there is licorice).
Otherwise, no known contra-indications in taking these with thyroid meds.
More research with well-designed prospective trials are needed to answer these tough questions.
Thank you.
The reason this issue has become confusing is because there are published studies (NID/CDC only studied full replacement steroids), treating subclinical hormone deficiencies, in disorders such as CFS and FMS, where their findings state that there is already a blunted HPA axis. There are Medical Centers, that use adrenal support in these patients, that do not have actual adrenal insufficiency (Fibro & Fatigue Centers) and these centers are staffed by all specialized and Board Certified Physicians. Below is the number of states these centers operate in. They began using adrenal support (same supplements I listed but sometimes also low-dose Cortef)as one of several combined treatments, after research conclusions, from studies going back to 1991, found that correct doses are safe, even for long-term treatment.
(14 States)
Amarillo, TX Atlanta, GA Boston, MA
Cleveland, OH Dallas, TX Denver, CO
Detroit, MI Fort Worth, TX Las Vegas, NV
Norwalk, CT Philadelphia, PA Pittsburgh, PA
Salt Lake City, UT Seattle, WA
The research; "EFFECTIVE TREATMENT OF CHRONIC FATIGUE SYNDROME AND FIBROMYALGIA