Aa
cAMP production? Hormones talk to endocrane system???
Does anyone have experience using this plant or know about it?
FORSKOHLII from plant Coleus and/or plant Plectranthus barbatus resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cyclic Adenosine Monophosphate (cyclic AMP or cAMP). Cyclic AMP is an important signal carrier that is necessary for the proper biological response of cells to hormones and other extracellular signals. It is required for cell communication in the hypothalamus/pituitary gland axis and for the feedback control of hormones.
Forskolin appears to bypass the need for direct hormonal activation of adenylate cyclase via transmembrane activation. As a result of this activation of adenylate cyclase intracellular cAMP levels rise. The physiological and biochemical effects of a raised intracellular cAMP level include: increased insulin secretion; increased thyroid function; and increased lipolysis (fat destruction). FORSKOLIN HAS ALSO BEEN FOUND TO INHIBIT platelet-activating factor (PAF) by interfering with PAF binding to receptor sites. PAF plays a central role in many inflammatory and allergic processes including neutrophil activation, increasing vascular permeability, smooth muscles contraction including bronchoconstriction, and reduction in coronary blood flow. After treatment a 30% to 40% decrease in PAF binding was observed. The result is again a transmembrane signaling that results in activation of other cellular enzymes.
FORSKOHLII from plant Coleus and/or plant Plectranthus barbatus resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cyclic Adenosine Monophosphate (cyclic AMP or cAMP). Cyclic AMP is an important signal carrier that is necessary for the proper biological response of cells to hormones and other extracellular signals. It is required for cell communication in the hypothalamus/pituitary gland axis and for the feedback control of hormones.
Forskolin appears to bypass the need for direct hormonal activation of adenylate cyclase via transmembrane activation. As a result of this activation of adenylate cyclase intracellular cAMP levels rise. The physiological and biochemical effects of a raised intracellular cAMP level include: increased insulin secretion; increased thyroid function; and increased lipolysis (fat destruction). FORSKOLIN HAS ALSO BEEN FOUND TO INHIBIT platelet-activating factor (PAF) by interfering with PAF binding to receptor sites. PAF plays a central role in many inflammatory and allergic processes including neutrophil activation, increasing vascular permeability, smooth muscles contraction including bronchoconstriction, and reduction in coronary blood flow. After treatment a 30% to 40% decrease in PAF binding was observed. The result is again a transmembrane signaling that results in activation of other cellular enzymes.
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