Had a TT in April of 2010, for Hurthle Cell thyroid disease, it was benign, since then was on Syntroid 137.5 and have continued to be tired and have be very cold all the time. My Labs were TSH 0.4 and Free T4 2.1, so as of last week-August 2012 the endo has changed me to Cyotmel 25mcg....1 before breakfast, 1 before lunch and 1/2 before dinner. I feel so much colder and more tired, and not to mention gaining weight like crazy!