Antibody test after 3 years

[sharanbr]

I am a confirmed case of Hashimoto's. I was tested for antibodies in June 2014. The results were as follows:

Anti thyroglobulin antibody 142.5 - positive
thyroid peroxidase antibody 440.3 - positive

As I haven't had any respite in terms of body aches, I did this test once again yesterday.
Here are the results:

Anti microsomal antibody (I assume this is TPOAB) - 20 - negative
negative  34

Anti thyroglobulin antibody - 244.9 - positive
negative   115

I don't know if disease intensity has increased as TOPAB count is now negative while ATG has increased.

Need inputs on how to interpret the state of my disease.

[Barb135]

Vitamin D is toxic at too high levels. Yours, at 120, is higher than recommended... it should be around 70-80.  If you're supplementing, I'd recommend that you stop.  High vitamin D can cause body aches/pain.  

Your vitamin B-12 is not horrible, but could stand to be higher. Low levels of vitamin B-12 can cause brain fog/difficulty concentrating. If you aren't supplementing, you might try a methyl B-12.

With the higher TgAb, you could be having an autoimmune attack for some reason.  It happens sometimes for a variety of reasons.  As noted above, some holistic doctors say autoimmune attacks can be stopped with diet, supplements, etc.  There's a lot of ancedotal evidence to support this, but the science isn't quite there yet, though the gut microbiome is proving to be extremely important in overall health.

Magnesium supplements are often helpful with body aches/pains.  Most forms of magnesium are okay, except the oxide form, which tends to serve mostly as a laxative.  Magnesium is necessary for the proper absorption of calcium, which we know is necessary for proper bone formation.   Magnesium also has many other functions in the body.

[Barb135]

I forgot to ask if you've ever had any symptoms or tests that might suggest Lupus...

Symptoms, other than the body aches, which apply to many conditions, include a butterfly type rash on the face, rash consisting of round or oval patches, mouth sores or nose ulcers, photosensitivity...

Blood tests include (but aren't limited to) Anti-nulclear Antibody (ANA),  anti double stranded DNA (anti ds-DNA), kidney function tests, etc.  

[sharanbr]

Barb,

Thanks a lot.

I take something called as D-Rise sachet once a month now. It is supposed to raise your Vit D level by 10. This is something I found on this forum from another member. I have taken one in Aug. So, I will do test first in September and then decide to continue Vit D supplement. I really did not know that high vitamin D can cause body aches. Can you point me to any article that talks about high vitamin D and body aches? One more issue is, I take multi vitamin supplement daily. That comes with 1000 IU of vitamin D. I hope this dose of vitamin D is not an issue though or I should stop multi vitamin supplement completely?

I have ordered Vit B12 sublingual tablets. These worked for me earlier.
I will start this probably a week from now and see Vit b12 levels in September.

I haven't been tested for Lupus. Apart from Endo doctor, I have been going to an Ortho doctor. He is the one who ordered RA, C-RP, Uric acid and sugar tests. when I go next time, I can check about Lupus. BTW, I don't have any of the symptoms you mentioned above.

[Barb135]

I look forward to seeing them all...

[sharanbr]

Barb,

Not all tests are from same test. These were done at different points. I have tried to post latest where same test was repeated.

Test  date - 4/29/2017

*Calcium, serum - 9.3 (8.5-10.6)
*phosphorous, serum - 3.4 (2.4-4.4)
*Parathyroid hormone, serum - 28.5 (14.-72)

*Free T4 - 1.39 (0.89-1.76)
*TSH - 2.32 (0.55-4.70)
*Vitamin D, 25 - hyrdoxy - 120

Test date - 7/2/2017

*Sugar fasting 80 (70-110)
*Sugar PP 114 (80-140)
*C-RP - 0.93 (<5)
*Uric acid - 5.3 (3.5-7.2)
*Rheumatoid factor < 12 (< 15.9)

Test date - 1/1/2017

*TSH - 0.91 (3.3-5.5)
*Free T3 3.4 (1.7-4.2)
*Free T4 1.38 (0.7-1.8)

Test date - 8/12/2017

*Thyroid antibody - AMA - 20 (< 34)
*ATG - 244 (<115)
*Vitamin B12 - 556 (211-911)

On your question about my symptoms. Body aches & stiffness have been my main symptom. I do have foggy head and tiredness but my tiredness could be from my body aches. Also, I tend to have more stiffness and pain in the morning and I feel at least 50% relieved by evening.

So, I am not sure.
This is how multiple joints started acting up one by one over the last 3 years
1) started with heel pain on right leg
2) some discomfort/stiffness in right knee
3) left heel discomfort and stiffness
4) left knee stiffness (no pain though)
5) shoulder stiffness. Left shoulder feels as is there is a tear in the shoulder joint
6) upper back pain

So, I am a bit worried as more and more joints have got involved over a period of time but no respite from any of the joint aches.

The fact that AMA test is negative after it was positive 3 years back gives me hope.

[Barb135]

Thyroglobulin is a protein used in the production of thyroid hormones and thyroid peroxidase is an enzyme used in the production of thyroid hormones... Antibodies to either of them indicate that your thyroid hormone production is being diminished.

Do you have test results for actual thyroid hormone levels?  Those would be Free T4 and Free T3.  Those results would tell us whether or not your thyroid is still functioning at normal levels or not.  It's the actual thyroid hormone depletion that would cause the body aches and other symptoms of hypothyroidism.

If you have results for Free T4, Free T3 and the pituitary hormone, TSH, please post them, so we can see what your thyroid function really is, since antibody levels don't tell us that.  Be sure to include reference ranges as those vary from lab to lab and have to come from your own report(s).

Antibody levels can fluctuate over time and the actual numbers don't really make that much difference... once you've been diagnosed with Hashimoto's, you have it for life.  There are holistic practitioners who say that diet and supplements can reduce the antibodies and destruction on the thyroid... the science is still out on that.

If you have other symptoms of hypothyroidism, please, also list them.

[Barb135]

sharanbr, I missed your screen name, when I responded... are the body aches the only symptoms you have left?  

Sometimes we have to look beyond thyroid. Have you tried magnesium supplements, vitamin D?  Deficiency of either can cause body aches...

[sharanbr]

Barb,
I will post details. I have all the reports with me.