I take both T4 and T3 at night. I wake up around 3 am every night anyway, so I take it then but I know many people who take it earlier, right when they get in bed. You should NOT take it earlier in the evening than your bedtime or you might get a second wind. Thyroid hormones peak around 3-4 am naturally and there's a whole school of thought that it's better to mimic that natural cycle. I sleep much better taking the hormones at night and it makes the morning better because I can have tea with milk as soon as I get up and also have breakfast without having to worry about it interfering with my medications. All you can do is try it and see if that pattern works for you. Or you might take 2.5 mcg along with your T4 at night and then take the other 2.5 mcg at mid-day.
I disagree with Barb about how long T3 stays in the body. As far as I know, T3 peaks around 4 hours after you take it, but it stays in your body for about a day and a half. Perhaps you should google that and see.
ps- i adjusted the meds up from 125 to about 131 to see how i feel and added the t3. Im taking 1/2 125 and 1/2 137 each night so I'm consistent. and then I'm taking as much t3 as i can tolerate which is about 5 mg
i take my t4 at night around 10 pm. if i take it in the morning, i get really exhausted during the day, my ears ring like crazy and i get blurry tired eyes.
if i take my t4 at night, most of the wackiness is gone by noon. It takes about 14 hours from the time i take the t4, til the time the craziness subsides.
when i wake up, I feel very anxious, agitated, depressed, almost like a huge caffeine jolt, but without the caffeine. almost like i drank a pot of coffee on an empty stomache. some people say that i am not taking enough and my body is feeling the effects of the t4 because its still adjusting. WHo knows.
I called my surgeon today, she told me if i was her patient, she would tell me to increase my dose. She said she likes to see it around 1 to 2 tsh and she told me my free t3 is low like you said. If i could just get over the morning wackiness, i would be able to make it the rest of the day.
I remember Lazy moose used to say he was under medicated for so many years, and once he was properly medicated he finally felt better.
My B12 is mid range, i inject once a week and it sends it up around 800 to 1000 . If i could inject everything once a week, i would. I hate pills.
Forgot to say - take T3 as soon as you get up in the morning, with your T4.
T3 gets into your system quickly, peaks and is gone, within a few hours. If you take it at bedtime, there still won't be anything left by morning,
What hypo symptoms are you having?
We've both been on here, for years, and we hear people say that as soon as they take a med with T3 in it, they feel it... I've never felt anything when I take T3. I've often wondered why I even take it, until I decide to try going without it. Then I realize that even though I don't get a big "kick" from it when it hits my system, it's still there when I need it - kind of like a faithful friend, not always in your face, but there, nonetheless.
Maybe you need to just take it at a low dose for a while and see what happens. Of course, talk to your doctor. Maybe you're like me - you won't get that "jolt", but it will build until one day, you won't feel like crap until noon, but maybe you'll need a nap after lunch. I still have days where I get really drowsy and need to take a quick nap, then other days, I'm good to go all day long.
I know we've discussed it before, but what about your B-12?
I had another question, just an idea. Barb , i took t3 today and seemed to of felt better. I did divide it into 1/4's and by days end i was able to consume the whole 5 mg pill with no problems. In fact i kept taking it , waiting for something to happen and didnt feel anything so i guess I'm depleted.
My biggest complaint is waking up and feeling horrible til about noon. What about taking a drop of t3 at bed time? do you think that may help or is that a horrible idea?