GERD is a major symptom of thyroid conditions... I had it horribly for years prior to being diagnosed with Hashimoto's and my doctors kept prescribing Aciphex, which a very strong acid inhibitor. After a few years, even the Aciphex wasn't touching the GERD. My ENT became concerned that the GERD would damage my esophagus.
After I joined MedHelp, someone suggested that I needed MORE acid, not less, which I thought was crazy, because I'd often wake up, literally, choking on acid. One night in desperation, I chugged some dill pickle juice, as had been suggested... It burned like fire going down, but lo and behold, after a while, things began to settle down a bit and I was actually able to sleep a few hours that night...
I started researching and found that many people with thyroid conditions actually need more acid, not less... I started drinking vinegar water, with a little honey, or the dill pickle juice. I found that peppermint oil pills also work wonders. Eventually, I learned that taking HCL with betaine helped a lot, but what worked best was getting my thyroid hormone levels where I needed them to be.
I haven't taken anything for GERD in quite a few years, other than a sip of dill pickle juice or peppermint tea, peppermint oil pills, etc. but then I only get it if I eat something that totally disagrees with me in the first place. I do enjoy a cup of peppermint tea anyway as it's soothing in its own right.
All of the symptoms you've been having - irritability, stress, ibs pain, depression and anxiety can be symptoms of a thyroid condition. They can apply to both hyper and hypo.
It's important to note that the TPOab antibody can be slightly elevated in Graves Disease, as well as in Hashimoto's; however, gimel is right that Hashimoto's can swing hyper, then hypo and may do this numerous times before finally swinging permanently hypo... I know I did it, I swung hypo, then hyper, then normal, at least 3 times, before settling to permanent hypo, though I didn't know what was happening at the time, because no one ever tested my thyroid levels... it was only after I turned permanently hypo and symptoms got so bad I was in misery, that I was actually tested and diagnosed.
In order to know exactly what you have, there's another antibody test you need to confirm Hashimoto's... That's called Thyroglobulin Antibodies (TgAb). Both TPOab and TgAb are, both, markers for Hashimoto's and need to be tested for confirmation. In addition, the definitive test for Graves Disease is Thyroid Stimulating Immunoglobulin (TSI) and you should get that, as well... Some people have, both, Hashimoto's and Graves at the same time, with one or the other being dominant at a given time.
As for your question regarding the use of cannabis, I can't answer that, however, I did find the following:
"It is unclear how medical cannabis might directly impact conditions such as an under-active thyroid gland (hypothyroidism) or an overactive thyroid gland (hyperthyroidism). However, many patients report that medical cannabis is quite effective in treating some of the clinical symptoms that are commonly associated with these diseases. Such symptoms may include anxiety/depression, irritability, headaches, insomnia, joint and muscle aches, and others".
If one is hypo, you must provide your body with the thyroid hormones that are lacking, because those hormones are what controls many of your bodily functions, such as heart rate, metabolism, body temperature and others. If one is hyper, your body is producing too much of the hormones and you must slow down that production... merely taking medical cannabis to alleviate the symptoms is not making the body healthier; it's making the person feel better, temporarily.
In your case, it appears that your body is producing too much of the hormones and you'll need to find out what's causing that and slow down the production, which will likely alleviate some of your symptoms.
This is a very interesting subject for further research...
In view of the TPO result, it is most likely Hashi's. I say that because with Hashi's it is quite common at the beginning for nodules to form on the thyroid gland. Those nodules then leak hormone faster than normal, thus the high levels of thyroid hormone and low TSH. The hyper phase may last for a while and then revert to hypothyroidism. I experienced that myself many years ago. I was just hyper enough that built a wooden deck and then finished the basement, all in a year. Then I became hypo and my wife likes to say that I haven't done that much work since. LOL
When you see the Endo I am sure you will get an ultrasound test of the thyroid gland to determine its condition. Not sure if the Endo will want you to just wait for the hyper period to end, or if symptoms are really severe, perhaps give you some anti-thyroid med to get you through.
The real challenge for you will be when you become hypo for good, as the thyroid gland is being destroyed by the antibodies of Hashi's. At that point you will need a good thyroid doctor that will treat clinically, by testing and adjusting Free T4 and Free T3 as needed to relieve symptoms, without being constrained by resultant TSH levels. Symptom relief should be all important, not just test results and especially not TSH results when taking thyroid medication.
I know I am going way beyond what you asked about, but for the future you need to know a couple of other things. Being an Endo does not guarantee a good thyroid doctor. Many of them specialize in diabetes, not thyroid. Many of them have the "Immaculate TSH Belief" and only pay attention to TSH. That does not work. If they test beyond TSH it is usually only Free T4 and then they use "Reference Range Endocrinology", and will tell you that a test result that falls anywhere within the range is adequate. That is also wrong. You can get some good info from this link written by a good thyroid doctor.
http://www.hormonerestoration.com/Thyroid.html
Finally hypothyroid patients frequently become low in the ranges for Vitamin D, B12 and ferritin. All are very important. D should be about 55-60, B12 in the upper end of its range, and ferritin should be about 70 minimum. so you can get those tested and supplement as needed to optimize. As you proceed with your diagnosis and treatment, please keep all this in mind.