Has anyone heard of this severe reaction before?

[NeedAswers2020]

Back in 2003, my thyroid levels dipped below normal. My doctor gave me a low dose of Synthroid.  Within an hour, I began to have severe muscle spasms in my ribcage. Soon after, they became widespread throughout my body. I went back to my doctor and they retested my blood and found that my T3/T4 levels actually went down.  

My doctor was very confused by this so he put me on Armour Thyroid. Within an hour, I had the same reaction. So he put me on Cytomel. An hour later, I had the same reaction. By this time (a few days later) my muscles were so tight, you could visibly see as rope-like structures under my skin. I was in agony. I still have unexplained muscle cramps to this day and have had dozens of tests to find out why but no answers.

Thinking that I may be having some kind of reaction to a binder in the medication, my doctor had a formula compounded for me. Unfortunately, I had the same reaction. Out of options, my doctor sent me to an endocrinologist. He could not explain the reaction and told me I "would not survive" if I did not take Synthroid.

I don't think the reaction I had was a drug interaction. The only drug I was on at the time was Zoloft. Interestingly, I tried a glandular adrenal support formula and had the same reaction?!

I went to a naturopathic doctor (out of desperation) and he gave me vitamin B-12 and magnesium injections. He had me take a powerful antioxidant, and some other things like kelp, dolce, and Irish Moss.  My thyroid levels went back up to low normal but I am not sure if it is because of anything he gave me or it was the fact that I stopped the Synthroid etc.   I stopped taking anything even the herbs/vitamines after my levels became low normal.  

Flash forward 17 years:  I REALLY need to find the answer because my TSH is becoming very high and my free T3/T4 are low normal. I am having an uptick in the classic symptoms of hypothyroidism again and I am too afraid to take any of those drugs again. Has anyone heard of this reaction? I cannot find any reference to it in literature or online. Any information would be helpful. Thanks.

[gimel]

Have you ever been tested for cortisol and ferritin?  There are reports of reactions occurring sometimes when cortisol or ferritin are too low in the range.  You can get your doctor to order tests for both.  Usually they will only order a morning serum cortisol (total Cortisol) test, which is not as useful as a diurnal saliva cortisol (free cortisol) panel of 4 tests at different times of the day, because cortisol levels change significantly during the day.   If you want you cn order a kit from a lab such as ZRT and do the saliva cortisol tests yourself, but I would start with the morning serum cortisol first.  

Symptoms are even more important for diagnosis than test results.  Please review this list and tell us all that you have.  
Fatigue
Increased sensitivity to cold  (temp. below 98.6 which is considered normal)
Constipation  ( have to use fiber or laxatives)
Dry skin (have to use moisturizer)
Weight gain  
Puffy face    
Hoarseness
Muscle weakness
Elevated blood cholesterol level
Muscle aches, tenderness and stiffness
Pain, stiffness or swelling in your joints
Heavier than normal or irregular menstrual periods
Thinning hair
Slowed heart rate
Depression
Impaired memory
Enlarged thyroid gland (goiter)
insomnia/sleep apnea
inability to cope with stress
cognitive dysfunction
hypotension, lightheadness
hot flashes
nausea, diarrhea, poor digetion
hypersensitivity to pain, light, noise
late evening energy (second wind)
require vigorous exercise to feel well
rhinitis, nasal congestion
headaches, tension, and migraine
depression,anxiety,irritability
myalgias and arthralgias
insomnia
palpitations, tachyarrhythmias
dry eyes
improvement on glucocorticoids
wheezing, shortness of breath

Also please post your most current thyroid related test results and their reference ranges shown on the lab report.  Hypothyroid patients are frequently deficient in cortisol, Vitamin D, B12 and ferritin, so if tested for those please post those results also.