Thyroid levels

[CathyW1969]

What does it mean when your Thyroglobulin and THYROID PEROXIDASE ANTIBODIES are both high?

[gimel]

When you were first diagnosed and having those symptoms, what were your thyroid related test results and reference ranges shown on the lab report?

[CathyW1969]

Most of my thyroid tests were within normal range than all of the sudden my TSH spiked.

[gimel]

Hashimoto's Thyroiditis produces antibodies that attack and eventually destroy the thyroid gland.   TPO ab are most frequent, with TG ab less frequent: however, having both is not unusual.  With Hashi's the gland produces less hormone, resulting in the pituitary  trying to stimulate more production by increasing its output of TSH.   The thing that may be inconsistent with that scenario is the weight loss you had.  That is more common with hyperthyroidism due to high fT4 and FT3 levels.   So I am wondering if your gland could be damaged enough that it periodically leaks thyroid hormone.  

At any rate, your doctor will need to prescribe enough thyroid med to get your FT4 and FT3 to about mid-range, and adjust from there as needed to relieve hypo symptoms.   I think you will need a full daily replacement amount of thyroid med, which is much more than the current 75 mcg of T4.   Your doctor also needs to decide what is to be done about the nodules causing nerve pain and swelling.  

[gimel]

Were you also tested for the active thyroid hormones Free T4 and Free T3?  If so, please post results and reference ranges shown on the lab report.  Even more important, please tell us about any symptoms you are having.

[CathyW1969]

My most recent T4 level was 1.27ng with the standard range being 0.58-1.64ng, My T3 levels are 3.0 pg/ml with the standard range being 2.5-3.9 pg/ml.  The thyroid Peroxidase Antibody level is 371.4 IU/ml the standard range is less than 9.0.  Thyroglobulin, Mass Spec is at 12ng standard range is 0. My TSH level was at 11.82 standard range is 0.34-5.60, on 75 mg Levothyroxine it is down to 2.97.  I initially started out dropping 20 lbs and losing my hair.  I was exhausted all of the time and just felt awful.  I have constant joint and muscle pain.  I am 5ft 3in and went from 135 to 113lbs in a very short period of time.  I have gained back to 126lbs now. I have multiple thyroid nodules with the largest one on the right side causing nerve pain and issues with swallowing.