Thyroid medication not working

[smorez]

My husband had to have his pitutary taken out because it had a tumor on it.  The .was so big that he went to radiation treatment's too.  This had been over twenty year's ago and slowly but surely he has had to start taking thyroid medication because to replace the thyroid hormones that he was lacking.  For some reason he has become just exhausted and has to take naps.  And this has happened over a time of three year's.  He went to the doctor and they increase his medication up to 175 mcg's.  He went to get the blood work up to see if this increase his tsh.  Well, the tsh went down to .04.  It also show's that alot changes in his blood.  
His eos is 6.8 high
momo 10.4 high
triglyc. 447 high
gluc 104.  high
creatine .75 which is low
rbc 4.26 low
tsh .04

I am confused at how he can increase his thyroid and everything goes to wild and his thyroid be in the toliet.  Any idea's?  I have all weekend to worry about this and I just hate that when this stuff happen's it alway's seems to be on a friday.

[goolarra]

"I am confused at how he can increase his thyroid and everything goes to wild and his thyroid be in the toliet."

TSH is counterintuitive...the lower the TSH (theoretically) the more hypER (high) your thyroid hormones, the higher the TSH, the more hypo (lower) the thyroid function.  So, on increasing meds, one would expect the TSH to go down.

Correct me if I'm wrong, but did your husband have his pituitary completely removed or just the tumor?  TSH is a pituitary hormone, so if he has no pituitary, TSH would be totally worthless in evaluating his thyroid status.  As Barb said, FT3 and FT4 are a complete necessity.

[Barb135]

It TSH the only test done on his thyroid?  You need also to have Free T3 and Free T4 tested.  Those are the actual thyroid hormones, with FT3 being the one that correlates best with symptoms, since it's the one used, directly, by the individual cells.

I agree that the TSH is too low, but the high Triglyceride levels indicate that he is hypo, not hyper.  TSH is a pituitary hormone and does not, often, accurately reflect actual thyroid hormone levels, especially when one is already on a thyroid replacement hormone.  

His low RBC also indicates an anemia.  He should get a full iron panel, as well as vitamin B12 testing.  He will need both to determine whether he has iron deficiency anemia or Pernicious Anemia.  Both will cause extreme fatigue.

Do you mean eosinophils and monocytes?  Both are types of white blood cells, and become elevated when there is an infection or inflammation present.

He should also get thyroid antibody tests done to determine if he has Hashimoto's Thyroiditis, which is an autoimmune disease in which the body sees the thyroid as foreign and produces antibodies to destroy it. The tests needed for that are Thyroid Peroxidase Antibodies (TPOab) and Thyroglobulin Antibodies (TGab).  He needs both tests, since some people have TPOab, some have TGab and other have both. Elevated thyroid antibodies could be an explanation for the high white blood cells, since they can produce inflammation.

Since your husband had his pituitary removed, I'd have to wonder if he's taking hormones to support other endocrine glands, such as adrenals and reproductive organs, since the pituitary controls those, as well as the thyroid.  

With his blood tests, I can understand why your husband wouldn't feel well; however, rather than spend the weekend worrying, why not try to relax (I know, easy for me to say), since there isn't anything you can do right now.  When is he scheduled to see his doctor to determine a course of action?