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Can I get pregnant by having sex the day after finishing my antibiotics?

My OBGYN saw me last week and told me I had a mild case of BV, and that he would give me antibiotics to take twice a day for one week. He said that due to the fact that antibiotics can weaken the effects of my birth control pill (Lutera), I couldn't have sex for one week. So, my understanding was not to have sex the entire week of taking the pills. After taking my last antibiotic, the next day I had sex, and my boyfriend ejaculated inside me. I have been taking my BC pill (been taking for last year) every day as usual even during the time of the antibiotics. I checked my calendar and we had sex the day of my ovulation. I looked online later and everyone says that you shouldn't have sex during the antibiotics AND one week after. Did I misunderstand my doctor, and could I possibly be pregnant by having sex the day after stopping my antibiotics? Thanks!
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Avatar universal
Some anabiotic's can decrease the effectiveness of birth control pills, but most do not. Metronidazole (Flagyl) is what is usually used to treat BV and it does not has not been shown to decrease the effectiveness of birth control pills. Because some antibiotics like rifampin used to treat tuberculosis may decrease the effectiveness of birth control some providers are just more comfortable telling people they should use an additional back up birth control method on any antibiotics. My guess is that your doctor was trying to tell you that you need to use an additional form of birth control like a condom if you're hoping to prevent pregnancy. The effectiveness of your birth control pills also highly relies on you taking them regularly. A lot of women are switching to methods that they don't have to remember every day and then there is no guesswork these include IUDs and the Nexplanon - there are a lot of great options that are better than unplanned pregnancy.

  Certain meds do interfere with birth control—not most antibiotics, though.

by Maria Isabel Rodriguez, MD published 10/15/2013
Many women using birth control with hormones—including the pill, the patch, and the ring—have heard that antibiotics can make these methods less effective. Thankfully, that’s not true for most antibiotics. But there are medicines that can interfere with some kinds of birth control. Let’s talk details, why these meds mess with birth control, and what alternatives women taking these meds have.


Most antibiotics do not make the pill, patch, or ring less effective—that includes antibiotics commonly prescribed for acne (doxycycline, tetracycline), a sore throat (ampicillin), a urinary tract infection (ciprofloxacin), or a vaginal infection (metronidazole). Lots of women who use the pill have also used these antibiotics, so scientists have heaps of data to prove that these antibiotics do not impact birth control.

So how did this rumor get started? It started with stories—“OMG, my best friend’s cousin’s neighbor was taking an antibiotic and she got pregnant”—and spread from there. If you’re taking antibiotics for diarrhea or nausea, being so ill may make it harder to absorb the pill, or harder to remember to take it. If you take the pill and have severe vomiting or diarrhea, check with your health care provider to see if you need to alter your dose. When in doubt, use a condom for backup.

There is one important exception: For women being treated for the lung infection tuberculosis, the hardcore antibiotic commonly prescribed (rifampin or rifabutin) can interfere with the birth control pill. We have good evidence that rifampin messes with the pill and may also affect the patch and the ring. If you are taking rifampin, talk to your provider about your birth control options. Rifampin therapy generally lasts months (6-9), so a different contraceptive choice might make sense for you. If you decide to stay on the pill, patch, or ring while taking rifampin, use a backup method like condoms consistently.

Mood stabilizer & epilepsy medicines

Women taking some medicines to treat bipolar disorder or epileptic seizures have a double reason to choose their birth control carefully:

1) Many of the medicines used to treat epilepsy and bipolar disorder—Barbituates, Carbamazepine, Oxycarbazepine, Phenytoin, Primidone, Topiramate, Felbamate, and Lamotrigine when taken alone—make the pill, patch, ring and mini-pill less effective, increasing the chance of an accidental pregnancy.

2) There’s some evidence that these methods of birth control change the effectiveness of those particular medicines, too. That increases the chance of having a seizure, or a manic or depressive episode. If you have epilepsy or bipolar disorder, it’s really important to talk with your provider about what birth control method is best for you—there are still good options!

Medicines for HIV

Some medicines used to treat HIV (antiretroviral drugs) make the pill less effective. Examples of these drugs include Nevirapine and Nelfinavir- and Ritonavir-boosted protease inhibitors (Darunavir, Fosamprenavir, Lopinavir, Tipranavir). There are antiretroviral drugs that do not mess with the pill, including Tenofovir. If you take an HIV medicine, talk with your health care provider about the risks and benefits of your birth control options.

St. John’s Wort

Saint John’s Wort is an herbal remedy that some people take for depression, anxiety or insomnia. Taking St. John’s Wort pills or extract reduces the concentration of both hormones (estrogen and progestin) in the pill by about 15%. For women taking the pill—especially a low-dose pill (20-35 micrograms of estrogen)—this changes the dose enough to make breakthrough bleeding more likely, but we don’t know exactly how this affects the risk of pregnancy. If you take St. John’s Wort and prefer to avoid taking risks with your birth control, consider using a method other than the pill, or use condoms to back up the pill.

How do these meds mess with birth control?

For the science geeks among us, here’s how this works: it’s all about metabolism, the process by which our bodies use and clear medicines. Just like with food, the body has an intricate and multi-step process for breaking down medicines, using them, and then clearing them from the body.

One of the key players for medicines is an enzyme (a special kind of protein that helps get work done) called the P450 system. The P450 system helps process both of the hormones in the pill, the patch, and the ring—estrogen and progestin. Some medicines speed up or slow down this enzyme system. If the system is revved up, it will go to work breaking down and removing the hormones faster than normal, resulting in lower levels of the hormones to get the job done. It can result in such low levels of hormone that the pill, patch, or ring don’t work.

What if I take a medication that messes with hormonal birth control?

There are many highly effective types of birth control that are not affected by these medications, including all IUDs, the implant, and the shot. Barrier methods like condoms are also effective regardless of what medication you're taking.

In general, it’s good to remember that medicines can have powerful interactions with each other—and hormonal birth control is just another type of medicine. If a new medicine is prescribed for you, make sure to tell your health care provider about all of the medicines, herbal and vitamin supplements you regularly take.
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