I am a 63 yo man who was healthy until 5 years ago when I developed an onset of joint pain, headaches, fevers up to 104.0, chills, nausea, vomiting, and fatigue. Flares occurred every 90 days like clock work. I was worked up by reputable medical center for Infectious disease, cardiac, rheumatology disease, lots of blood work, bone marrow biopsy, MRI, CT scans, etc. Every result was either negative or marginal. I was found to be anemic, positive ANA low titer, elevated sed rate, and low RBC count. Initial I was treated with plaquinel and folic acid. After about eight weeks m flares occurred less often and fevers were low grade. Other symptoms continued and cognitive dysfunction started. About six months later I was put on Methotrexate and titrated to 25 mg. injections per week. Began to feel a little better but joint pain continued. About 3 months ago I was put on Humira injections biweekly. At present feeling much better. Naproxen helps joint pain when needed which is about every 3 days. More energy and mental fogging improved. Current diagnosis is undifferentiated mixed connective tissue disorder with primary symptoms reminiscent of Lupus. Has anyone had a similar experience? Please share. Thanks.