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VGKC voltage gated potassium channel antibody disorder

Hi - long shot I know, but has anyone heard of a "voltage gated potassium channel antibody disorder" is associated with MS.
I have tested positive for this in two blood tests and am aware that there isn't a blood test for MS, but does this provide a pointer towards/away from MS.
My other blood work was normal.
I have had twitching symptoms in various muscles  and eyelids and some leg pain/numbness/burning sensation.
Brain MRI in October 2015 was clear/negative.
Male aged 43.
thanks
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Avatar universal
Hi, I have a positive vgkc and twitching too, plus many other symptoms.... Did you ever find a cause?
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Avatar universal
I have MS and twice confirmed VGKC antibodies. Not sure if that is common at all, and I am not sure if those findings are related or separate, but just wanted to chime in. My MS symptoms are more prevalent than neuromyotonia (VGKC antibody) symptoms. Not sure if any other MS-ers would have these antibodies if docs looked for them. It's not a common test to perform. Original poster, sounds like you have alot of the twitching cramping symptoms that I've seen in my neuromyotonia groups. Hope you get some answers soon if you haven't already!
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Avatar universal
Thanks Aspen2 - I don't have weakness - or at any rate none that's been detected in Neuro exams, and I've been doing some weight training and increasing the weight loads.
I'll wait and see - I think the Neuro is pretty much minded to observe things, as the treatment for vgkc is apparently immuno-suppression.
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5265383 tn?1669040108
This test points away from ms as a cause -- I had this test done as well.  It's something more to do with transmission of signal at the junction between nerve and muscle, rather than central nervous system issue like MS.

When do you see your neurologist to talk about the results?  All these tests get pretty confusing, and your neurologist will be the best person to sort out what it means for you.
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2 Comments
Thanks Aspen2, I wasn't sure as my initial MRI was for Ms.
I take it your VGKC test was negative?
Yes, mine was negative ... A positive test can point towards some peripheral nervous system causes (like cramp fasciculation syndrome) or some alternate neuro disorders.  This is one of those tests that is best discussed with your neurologist.

Do you have weakness as well, or just the pain/numbness?  Have you had a whole lot of blood work done? Important tests (some that are not done routinely) are B12, vit. D and magnesium.

Not a doctor, but I was in limbo for three years and had a lot of testing done ...

Keep us posted!

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