Condyloma AIN2 while P16 Negative ?

[HL8703]

I posted my original question here but somehow got moved to colon cancer forum.
I just needed some help understand the biopsy results below, although it's AIN I guess it's comparable to CIN in terms of LSIL and HSIL?
'High grade squamous intraepithelial lesion (HSIL; AIN-2) arising in a background of condyloma acuminatum with low grade squamous epithelial lesion (LSIL; AIN1).'
'Immunohistochemical stain to p16 fails to show diffuse strong staining'

So is this same to say p16 is negative? But would pathologists normally downgrade HSIL if p16 is negative?
How can I interpret the diagnosis of HSIL/AIN2 out of LSIL/AIN1 with the p16 being negative?
Appreciate it for your help and kind advice!

[auntiejessi]

We moved your question to colon cancer because you'd already posted in anal cancer with no response, and because this question is really not best served here in the STI forum.

I know it's an HPV question, but you really should be asking your doctor these questions. I would hate to give you the wrong answer. We are not able to tell you what the doctor or pathologist will do, and that will be based on your specific findings.

I did get your question moved to Anal Cancer, though. That's more appropriate.

[HL8703]

Thanks for clarifying, I still think the question is more suitable here than the colon cancer section, it is HPV, it is STD, and more similar to women's HPV infection and concerns than to colon cancer, as the same classification and grading terms can tell.
One good benefit people posting questions here before they go to their doctors is to look for some degree of clarifications before they lose their minds or get lost in the google searching, no one says the clarification should be 100% medical proof or from absolute  med-professionals, the understanding and shared experience from people who have been through the same could offer mighty help and comfort.
I thought that's why it's named 'MEDHELP' here not 'MED-ASK YOUR Dr'.
The biopsy result is not a too hard to read, it's very common for HPV infections and very common in gynecology too, I never thought it'd be too much to ask just because the STD infection is located in a different place.

[auntiejessi]

If I answer your question, I'd just be googling.

Perhaps someone will come along with the answer, but I have to say that if a woman with a pap smear with these results came along, I'd have it moved to women's health. Your issue is now beyond a regular HPV issue.

You can ask MedHelp, and we will sometimes refer you back to your doctor or to a pharmacist. We are not experts.