J. Kyle Mathews, MD, DVM  
Male, 63
Plano, TX

Specialties: Urogynecolog, Pelvic Reconstructive Medicine

Interests: Women's Health, Bladder Diseases
Plano Urogynecology Associates
Obstetrics and Gynecology
Plano, TX
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What is Interstitial Cystitis and What Causes It?

Aug 09, 2010 - 3 comments





Interstitial Cystitis



Interstitial Cystitis (IC) or Painful Bladder Syndrome (PBS) is a condition of the urinary bladder associated with pelvic pain, pressure, or discomfort with persistent urge to void in the absence of urinary tract infection.   The condition was first given its name in 1887 and has undergone several name changes and diagnostic criteria.  Over 33 million Americans are affected by urinary dysfunction making this condition more prevalent than adult onset Diabetes in the U. S.

Individuals who have IC often have decreased quality of life measures and report adverse affects on leisure activity, family relationships, and travel.   The condition is found in women more than men and depressive symptoms are common.  

While there are a number of diagnostic criteria for IC, there is no agreed upon gold-standard test that reliably makes the diagnosis.  IC is therefore mostly a clinical diagnosis based on symptoms and signs, although, a number of tests are helpful.  Among women, IC is often confused with other causes of chronic pelvic pain such as endometriosis.  A study-examining women who had persistent chronic pelvic pain after hysterectomy found 80% to have IC.  

The cause of interstitial cystitis is unknown but two theories are often proposed.  The most popular theory is that an injury or insult to the bladder fails to heal completely causing a defect in the protective layer inside the bladder.  This defect allows leakage of urine into the bladder wall that stimulates pain receptors and causes inflammation.   The second theory suggests that other disease processes such as endometriosis, irritable bowel syndrome and fibromyalgia irritate nerves in the pelvis that innervate the bladder.  The theory suggests irritation of these nerves results in chronic bladder pain.

J. Kyle Mathews, MD

Plano Urogynecology Associates

Plano OB Gyn Associates

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by minxster, Aug 09, 2010
i have diabetes which is very poor controlled, i suffer about twice a month with cystitis, do you think this could be to do with my blood sugar?

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by J. Kyle Mathews, MD, DVMBlank, Aug 15, 2010
Poorly Controlled Diabetes can make you more prone to infection, not to mention having increase in the need to urinate.  To my knowledge, there is no association with Diabetes and Interstitial Cystitis.  JKM

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by tiredofbladder, Nov 20, 2010
I had a vaginal hysterectomy two and a half weeks ago. (Only my uterus was removed.) They also did a cystoscopy to check for any growths in my bladder.  None was found.  However, since the operation I have suffered with painful urination.  My urine has been tested twice this week and there is no infection.  I had to go back to theatre last night to drain a vault abcess that formed after the hysterectomy.  The gynea was convinced that this was also causing the painful urination, but tonight after the abscess has been drained I am back to square one.  I have also suffered a really bad spell of spastic colon last week, but the pain seems to have subsided after medication.  Nothing not even the strong anti-inflammatories or painkillers I am on, makes any difference to the pain when I urinate.  I am now getting to a place where I am scared to go to the toilet.  Is there a chance that they damaged my bladder's protective layer during the cystoscopy?  The gynea is not very forthcoming with information regarding this.  Could you please advise?

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