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Recurrent Miscarriage - Plz read girls.

Sep 07, 2010 - 5 comments
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Miscarriage

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recurrent miscarriage

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treatment



Ive just been watching a programme about a woman who had these killer cells which killed of any growing embryo. Thought it would be helpful to some girls on here.

Natural Killer Cells -

Despite their fierce name, natural killer cells are actually a very important type of cell in the human body. Natural killer (NK) cells help to fight off various infections as well as cancer. In some women, though, NK cells can over react to a potential pregnancy, attacking the embryo. The end result is a miscarriage. However, a simple test can determine whether NK cells are the culprits behind your multiple miscarriages.

Natural Killer Cells: What are They?
Natural killer cells are generally a helpful type of cell, which aids in protecting you from various infections and even cancer, as these cells target tumor cells. NK cells receive their name from the fact that are produced naturally by the body and their sole purpose is to search for and destroy harmful cells.

When a harmful cell is located, natural killer cells bind to the invader and produce a cytotoxic (meaning that it is deadly to cells) chemical. This chemical is called tumor necrosis factor (TNF) and is actually a type of chemotherapy drug. Once the TNF has been excreted, holes begin to occur in the membrane of the invading cell. Because of the holes, fluids leak in, ultimately resulting in the cell bursting.

Why Natural Killer Cells Cause Miscarriage
In some women, the natural immune system response of the NK cells goes into overdrive. This means that the NK cells view the embryo as a cancer and decide to take action. Once the embryo has been identified as an "invader", your NK cells will multiply in number in order to have more killing power. They will then attach to the embryo and kill it in the same way they would kill any other cell.

Because this is not a typical response of the immune system, it is likely that you will experience multiple miscarriages due to NK cells. However, with a proper diagnosis and treatment, it is possible to successfully achieve pregnancy.

Diagnosing NK Cells
To determine whether your multiple miscarriages are due to natural killer cells, a simple blood test will be performed. For this test, a sample of your blood will be taken and the NK cells isolated. These cells will then be cultured with various solutions to see how they react.

Embryonic cancer cells, which are similar to embryos and placentas, are used in combination with the NK cells to see how the NK cells react to a potential pregnancy. The embryonic cancer cells will have a special type of dye applied to them for easier identification by your fertility specialist. After two to four hours, a second dye will be added to the solution. Only the dead cells will absorb this dye, not the living cells.

Next, the sample is placed into a flow cell cytometer, where all the cells are forced to pass by a laser in single file. The beam emitted from the laser causes the dye to fluoresce, thereby allowing the cells to be picked up by the computer and counted. This process will give your fertility specialist an accurate over-active NK cells.

Treatment
Useful treatment is available if you are found to have elevated levels of natural killer cells in your system. The main form of treatment tends to be IVIg infusions, a type of intravenous drug that helps to suppress the immune system. IVIg therapy has been shown to have an 80% success rate associated with it.

If you have been diagnosed with natural killer cells, it is important to also have regular monitoring of your thyroid performed. Approximately 5% of women with elevated natural killer cells will develop hypo- or hyperthyroidism. Therefore, it is necessary to have yearly thyroid testing done.

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1219499 tn?1410749730
by dscoqn, Sep 07, 2010
Thanks for putting this up hun.  I have read lots about NK cells and brought it up at my last appointment at the recurrent pregnancy loss clinic I go to.  They basically told me there hasn't been enough research done on it in New Zealand and they don't test for it or treat it :(


1186852 tn?1423660370
by xx_Louise_xx, Sep 07, 2010
Ahh thats a shame! :(

1303813 tn?1303159362
by Cassandrajane, Sep 07, 2010
So basically, people can have the stuff that is used for Chemo in their immune system?? That is always going to cause a Miscarrige..?? Unless you have it fought off??

Hmm....

Why dont thhey do more research in New Zealand?? And test for it and treat it? Because that isnt very fair.

x

1201929 tn?1293708072
by onyxangel, Sep 07, 2010
Wow... this is imperative information for ANY woman to know about. I'm so shocked that New Zealand wouldnt at least test it  after going through other channels first. Very interesting information Louise. Thanks for this
xx

1219499 tn?1410749730
by dscoqn, Sep 07, 2010
Yeah apparently our country doesn't have the money to put into researching it which stinks.  She said maybe in the future we will.  I know in England it's a big thing and lots of money has been put into researching it and women are being treated for it.  I also think Australia treats it to so I might have to save up and fly over (only a 3 hour flight from New Zealand) and get tested.

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