Jordanna Joaquina, MS, CGC  

Interests: Prenatal Genetics, Pediatric Genetics
Los Angeles, CA
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Does Genetics Play A Role in Infertility?

May 28, 2009 - 5 comments

infertility and genetics


non-genetic causes infertility


genetic causes of infertility


klinefelter syndroem


Turner Syndrome


y chromosome deletion


cystic fibrosis




Sickle cell anemia


Fragile X Syndrome


chromsome translocation

Infertility can result from many different causes including genetic causes, non-genetic causes, or a combination of both. Different types of evaluations and tests are often needed to establish cause (if possible). Detailed personal and family histories are assessed in order to prioritize which evaluations and tests will likely be the most informative.

A couple of proposed non-genetic causes may include:

- Drinking alcohol
- Smoking cigarettes
- Environmental exposure to harmful toxins, chemicals, or medications
- Uterine abnormalities (like bicornate uterus and fibroids)
- Age
- Stress

Some of the more common genetic causes may include:

- A parental chromosome abnormality (such as Klinefelter syndrome, Turner syndrome, Y chromosome deletion or a structural rearrangement in chromosome material called a chromosome translocation)

- A parental genetic condition (such as cystic fibrosis, Fragile X syndrome, galactosemia and sickle cell anemia)

For more information on the genetic and non-genetic causes of infertility, visit http://AccessDNA.com/condition/Infertility/207

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by adgal, Jun 04, 2009
I am not sure if this counts as infertility or not.  I am one of those women who gets pregnant very easily, but can't seem to carry past first trimester.  I have had 5 miscarriages, and it's 50/50 with my current pregnancy.  I have no living children.  They have done tests, but not been able to determine a cause.  My mother had 7 miscarriages, and I am her only living child.  I often wonder if there is something to that. For her, all her losses were in her early 20's to early 30's.  In my case all late 30's and at 40.  She also conceived very easily.  Are there additional tests I should be requesting, does anyone know?

Avatar universal
by bt1026, Jun 04, 2009
hi amanda,
my problem is the same as urs. i get pregnant easily n then m/c. had 3 m/c s so far. high insulin could be a reason for m/c. so chk for insulin levels. high insulin occurs when u ve insulin resistance. the medication for this is metformin. Also pcos cud be another reason for infertility.
i am happy tht u still ve the pg symptoms n i pray tht u carry this baby full term.. praying for u.. God bless

Avatar universal
by dms89, Aug 09, 2009
Hi. My husband is positive for the hla-b27 gene. I want to have kids in the future with him, but he says he cant due to his last wife having 8 m/c s. I would assume that it would have to do with her body, but he says that she was fine. I cant find anything on infertility and this gene. Do you know if this gene causes infertility?

Avatar universal
by infertilitysocial, Nov 04, 2010
Just read a great book on Overcoming Infertility by Dr. Jay Nemiro. He explains infertility with great passion and going to visit it at his Arizona Fertility Clinic.

Avatar universal
by infertilitysocial, Nov 04, 2010
or just go to www.overcominginfertilitybook.com is u dont want to spend money ;)

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