Cat seems depressed - Is this possible?

[Calfran]

My 2 year old male cat seems different to me lately.  It is almost as if he is depressed.  He is not as interactive as he previously was and my female cat (we got them at the same time 2 years ago) doesn't peak his interest like she has always done in the past.  He just lays around like he is sleeping but I notice that his eyes are open and when i try to get his attention he doesnt move his head or get up or anything....he just moves his eyes around.  I don't notice him to be in any sort of pain and he eats and drinks like he always has.  No major changes at home.  He has had a h/x of urinating out of his litter box and yes we have taken him to the vet numerous times and even to different vets for second opinions.  He seems to be doing it more lately ever since I noticed him being more depressed.  We have gotten him every kind of litter/litter box under the sun and have been so mindful of the litter box situation and clean it out very frequently.  He has had uti's in the past (3 times) but even when he didnt have the uti he still urinated outside of the litter box.  He is an indoor cat as well.  He has a million toys and things to play with and we try to play with him all of the time and interact with him and we give him top quality food and top quality water.  Any ideas?

[HerlindasAngels]

Have you tried getting him catnip and rubbing some between your fingers to get the oils out and sprinkle some around some of his toys? Buying a feather on a string and playing? Putting him on a leash and letting him check out the outdoors for some stimulation? Try it.... He's just BORED?!

[Cliff Redford, DVM]

We call these "ADR" cats. ADR stands for "aint doing right". In other words, they are still eating and drinking, no significant vomting etc., they just "aint doing right". Diagnosing the cause is a challenge but requires a physical exam and lab tests (urine and blood work). If these tests are normal then depression can be the diagnosis and we will prescribe anti-depressents. Sometimes even prozac. This may sound unusual but we forget at times that cats are not pack animals like dogs and the occasional cat becomes very stressed when living with a family and/or another cat.