Effexor with sideeffect sick and tired

[Kassandraom]

I started with 187,5mg Effexor and my strong depression went away in 3 months. Because of a dizzy brain, difficulty in concentration I reduced to 75mg. But still I feel sick and tired in the afternoon - strange but it becomes better after meal. But I have to take a antidepressiva for a long time, to reduce the risk of a fallback. So I search for a better drug with less sideeffects.
I tried zoloft and citalopram but the sideeffects were worse. I fear to change the drug and I hope for a tip that may prevent more trial and error attempts. My doctor proposed cymbalta.

[Sandra Y, RPh]

Effexor is in the class of medications known as Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs) and are mainly used as anti-depressants. The side effects that you are describing are somewhat common side effects many experience from this class of medications. Zoloft (Sertraline) and Celexa (Citalopram) are in a slightly different class known as Selective Serotonin Reuptake Inhibitors (SSRIs) but are also used to treat depression with similar side effects. Cymbalta, another SNRI is a medication that may work for you. With depression people respond differently to each medication and there is no way to tell if a medication will work unless you try it and give approximately 2-4 weeks for the medication to begin working.

[Kassandraom]

Thanks a lot for your answer. But it seems to me that you propose another trail and error change of drugs. I search for a systematic analysis of medicaments that prevents painful changes with risk of remission of depression.