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Spotting During Pregnancy while using Progesterone

I started using progesterone cream in Oct. 2001 for controlling PMS.  It was not very effective and was switched to 200mg progesteron tabs, twice daily, to begin in Dec.  However, because my husband and I were also trying to conceive, was told to wait to begin the progesterone after ovulation to avoid problems with the egg releasing.  Last period was 11-21-01.

About 1 week after ovulation, approximately 12-14-01, and before starting the progesterone tabs, I had streaky,pinkish spotting.  My doctor said it could either be due to egg implantaion or due to not using the progesterone yet which had been used in the cream form the 2 previous months.

After starting the progest. tabs twice a day as directed, the spotting tapered to nothing within 5 days.  Then over Christmas, twice, I forgot to take a tablet in the evening then resumed the regular dosage.  During this time, I also took a home pregnancy test and it was positive!

Two days later, 1-1-02, I had pink spotting again.  It has continued for 6 days, turning brown when my doctor suggested taking one tab, then turning pink again when doctor suggested taking two again.  I also had sharp shooting pains in my lower abdomen but have diminished to almost none now, 1-6-02.

I was on bed rest for 3 days then doctor said it was okay to get up and get back to normal routine.  The spotting seems to remain pretty consistent whether I'm on bed rest or up moving around.

The doctor did find a urinary tract infection and has put me on 500 mg of amoxicillin and thought the infection could be causing irritation to my uterus.

A sonongram was done 1-2-02, but it was too earlier to see anything but it did not appear there were any cysts or fibroids.  On 1-03-02, a blood test confirmed a pregnancy.

In conclusion, I'm taking 2, 200mg of progesterone while pregnant and having spotting.  Can see small pieces of pinkish tissue in toilet after using bathroom.

I've have one normal pregancy, 4 years ago, with no miscarriages to my knowledge.  Is the spotting due to the fluctuation in the progesterone, and am I possibly getting too much progesterone?  Or, am I working on a miscarriage?  The doctor did blood work on 1-4-02, but I have not heard the results as of yet.

I wished I would not have started taking this progesterone with all the problems I've had.  Your input would be greatly appreciated.  Also, should I be seeing a doctor specializing in high risk preganancy?
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Avatar universal
mgh
I am by all means not a medical specialist.  But I've had my share of problems during pregnancy.  I always suffer from Hyperemisis and usually end up hospitalized.  Fortunately my first pregnancy turned out okay and I had a health baby.  I had Hyperemisis with my second pregnancy and it ended up in a miscarriage.  I just found out that I am pregnant about 4 days ago.  My Dr confirmed my pregnancy with a blood test.  And she also checked my progestrone level.  It was a little low and she put me on a progestrone suppository.  

It is my understanding that it's very normal to check progestrone level during pregnancy and regulate it if it's low. Several of my friends have had to use it as well.  I know the big factor with me is that the Dr is concerned about another miscarriage.  So if anything....progestrone would help prevent it....not cause it.

Perhaps (like the post above said) there is a confunsion between natural and synthetic progestrone.
Helpful - 0
Avatar universal
I just had IVF done, and I was injecting 1cc Progesterone in oil intramuscularly every night for over two weeks.  I had apparently a chemical pregnancy-ie had noticable hcg levels on Day 11 after implantation then they lowered on Day 15.  At that time doctor said to go off of progesterone and I will start my period.  When should I start my period?
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Avatar universal
Dear Dr. Tomasello,
I still agree with you on the safety factor of this medication, but for your records and the records of your colleagues, I thought this website might be of intrest to you if you have not seen it before.  Go to http://www.perinatology.com/exposures/druglist.htm  then when it comes up there will be a small window in the center with a list of medications in it.  Just scroll down it until you see Progesterone.  When you do just click on it and go from there.  I hope that helps you out some.  Again, I still agree with you but I was shocked when I read this and I think you may be as well.  Let me know if we all stand corrected.  Thanks Once again for you time and Input.

Sara Hoke
Kentucky
Helpful - 0
Avatar universal
Dear Dr. Tomasello,
Granted, I had a very high Risk Pregnancy History including pre-eclampsi, Eclampsi, HELLP Syndrome, Concealed Placental Abrubtion resulting in Neonatal Death of my infant Daughter and Gestational Diabetes, Pre-term Labor in addition my 4 year old son was a twin and I lost his twin at 7 weeks of gestation and the sac did not expell itself which then I had to worry about that but for 100% fact those other 4 miscarriages where proven without a boubt to be caused from this medication.  I had to be seen for my other pregnancies by a perinatologist in Lexington KY out of UK Hospital by the name Of John O'Brien.  You may of heard of him.  He was in the news paer a few years ago for developing a way to allow a fetus to be carried longer after the membranes rupture early on in gestation.  Anyway the doctor who gave me this medication was in FLA when I lived there and it was a real mess so I just wanted to tell you that I supported you and your opinion and feel that you are correct in your comment.  Thanks for your input and please continue with this website because I really feel that it gives me and so many other people a chance to hear anothers side of things.  Thanks so much for your expertese and Good Luck.

Smokeater! :-)
Helpful - 0
Avatar universal
Thank you for your feedback.
This post has troubled me a bit. And without a doubt it is controversial. Personally, I would never prescribe this medication to a pregnant woman, and as I mentioned above, my two colleagues (one a FP who delivers about 100 babies/year and another who is an Ob/Gyn who delivers 300 babies/year) agree that this is not what one would consider to be "safe" to take during pregnancy. That is my opinion. I would not prescribe it.
Helpful - 0
Avatar universal
Dr. Tomasello,
I am not on here to agree or to disagree with anyone but I made the mistake of listening to one of my doctors and did take progesterone during pregnancy and I miscarried 4 times before they realized what was causing it.  I'm sure there are alot of people out there that have and still do take that medication with no problems and I'm greatful that they have successfully carried their babies to term with no complications but in refrence to your input to the young lady who was spotting I do think it is important to let people know that it is very true that the FDA does not approve of this drug and I am the very proof as to why they dont.  It is not safe.  I have 4 dead fetu's becuase of the unsafeness of this drug during pregnacy and the very fact that patients and doctor's either aren't aware or just don't care of the harm that it is capable of is very sad.  I think that more information should begiven to doctor's and patient's when a medication is prescribed.  Just because a doctor hands you a presciption and says here take this does not mean you have too.  You as a patient have a right and a responsibility to yourself and your unborn child to research what it is that you are putting in your body before you ingest it to make sure that it is safe for all concerned.  You can't always trust what your doctor say.  No offense Doctor, but they either aren't always truthful, or they simply aren't always fully informed about what it is they are giving you and the risks that it poses to you and your baby.  Thats all I am saying.  With all do respect to everyone who has posted a comment and the doctors too, I value all your opinoins very much and think all of you make very valid points, but I just think that we all need to take more responsibility to know what it is we are putting in our bodies.  I have taken this drug and payed dearly for it.  It is not safe for pregnat women.  It is not safe for unborn children.  I have for children lost not here with me today because of it.  No one can tell me otherwise.  That's all Im saying.  Thanks.  Godd Luck to the girl who was spotting.  I hope your pregnacy goes well and you have a healthy happy baby.  May God Bless you all.
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