Have you had these pain meds before? ... and without any allergic reactions? Also, there maybe some new antibiotics involved as well, or maybe the adhesive to some bandaging?. I would just be concerned that some allergic issues maybe in play here. If your medical team is aware and ok with it, then that's the best you can do. Off-hand, from just a simple observation (no data really), it seems like some type of irritation or allergy issue.