I have had the PVC problem for years and had much success with beta-blockers, but for some reason over the passed month I have been getting a large amount of pvc's every day, all day and all night. I take toprol xl, 100 mg. once a day. It seems totally ineffective. I'm not as afraid as I used to be of these things but I am very concerned about this increase which is affecting the quality of my life. My doctor, a general practitioner, refuses to change or increase my medication. I used to go to a cardiologist, for 15 years who always changed either the dosage or the medication whenever I had a problem. Then when the pvc's would decrease we would go back to the old dosage. He retired. The next cardiologist I went to does not believe in treating a benign condition with medication so he sent me to a phsycologist.Didn't help! I'm a 47 year old female with 4 children. Could this be perimenapausal in nature? I was told about 20 years ago that I had MVP but then 10 years ago had another echo-cardiagram and was told no mvp. Should I be going to a cardiologist since my regular doctor doesn't want to do anything? I still go to the psychologist who thinks I should get a second opinion (physical not mental).I tried to ask my doctor about perimenapause but he wasn't interested in discussing it. The pvc's increased when I was sick with some kind of stomach virus with severe pain in my right upper abdomin which my doctor thought was a gall bladder attack. I had an ultrasoun but nothing was wrong.My heart has been terrible ever since.The pain lasted for three days and then a general soreness for three days. It's all gone now.I know this is getting too long of a question, Thank you for your time. It means alot. Martie