Aa
cryoglobulins/treatment and HCV
I have done my homework (as per the web). been to a load of doctors. I was "Cured" in 2000, have felt like everone else. My diagnoses after treatment etc. are MGUS, Proteinuria, and I have tried to find info into Cryoglobulins and RF factor to make sure I don't have Cryoglobulimia. Has anyone looked into this? Thank You.
Hi do you have signs of cyroglobulinemia? I had signs of it a couple of years before my diagnosis of HCV. I had red dots covering my lower legs. As time went on, after I relapsed the first time, they became large purple blotches and very very painful. It would feel like my ankles were broken, legs very swollen. I tried to get tested for it a few times at the Quest lab
I finally had to go to a hospital to get tested for it. It came back positive. Since being cured of HCV I have seen no signs of it but have never been retested either.
Take Care
I finally had to go to a hospital to get tested for it. It came back positive. Since being cured of HCV I have seen no signs of it but have never been retested either.
Take Care
What exactly are the abnormal lab values that have lead to the diagnosis of MGUS and Proteinuria? Lab indicators of too much protein in blood and urine? If I am understanding correctly, they have no symptoms (other than possible tingling/numbness with MGUS), are not generally serious conditions, and are found quite secondarily of other lab tests.
When you say, "...have felt like everyone else", do you mean muscle/bone pain, fatigue, and never feeling well again? If so, I have experienced the same since tx and searched for answers from several doctors and specialists. My primary physician just kept sending me back to the rheumatologist. It was not until I found a very good endocrinologist (and even they are not all created equal in investigating our symptoms and labs) that I think I have found some successful treatment. My thyroid function was previously checked by more than one doctor (including my PP and the rheumatologist); however, too many doctors do not know how to "check it" and missed putting together all the various "off" clues in my labs, like the protein in yours. In my case I was flushing out calcium, not protein like you. It is tied to my thyroid and was not a mystery at all to the endo.
My symptoms of neuropathy were due to low Vitamin B12 and also went away when I addressed it. I am glad I did not start taking Lyrica as they wanted me to take.
Since learning from him that interferon damages the endocrine system I am of course trying to spread the word in hopes of helping others to solve their mysterious and debilitating symptoms.
First of all, cryoglobulimia is very much associated with HCV and/or its treatment with interferon.
Google: "Thyroid involvement in hepatitis C - associated mixed cryoglobulinemia" (The pdf of the entire study can be found at www.hormones.gr/pdf/Hormones_2014-16.pdf)
Google: "The Renal Manifestations of Thyroid Disease" (or you may find it with this link: jasn.asnjournals.org/content/23/1/22.full) which says,
"Patients with nephrotic syndromes have urinary losses of proteins that bind thyroid hormones, including thyroxine binding globulin, transthyretin, and albumin. This can result in reductions in total plasma T4 and less commonly total T3 levels that are roughly proportional to the severity of hypoalbuminemia and degree of proteinuria."
I also suggest you google the terms:
"Thyroid function in patients with proteinuria"
"Interferon alpha treatment and endocrine disease"
"MGUS and thyroid"
Once you start googling your DXs with "thyroid" I think you will find a wealth of associations with proteinuria, cryoglobulimia, MGUS and thyroid disease.
I hope this helps.
When you say, "...have felt like everyone else", do you mean muscle/bone pain, fatigue, and never feeling well again? If so, I have experienced the same since tx and searched for answers from several doctors and specialists. My primary physician just kept sending me back to the rheumatologist. It was not until I found a very good endocrinologist (and even they are not all created equal in investigating our symptoms and labs) that I think I have found some successful treatment. My thyroid function was previously checked by more than one doctor (including my PP and the rheumatologist); however, too many doctors do not know how to "check it" and missed putting together all the various "off" clues in my labs, like the protein in yours. In my case I was flushing out calcium, not protein like you. It is tied to my thyroid and was not a mystery at all to the endo.
My symptoms of neuropathy were due to low Vitamin B12 and also went away when I addressed it. I am glad I did not start taking Lyrica as they wanted me to take.
Since learning from him that interferon damages the endocrine system I am of course trying to spread the word in hopes of helping others to solve their mysterious and debilitating symptoms.
First of all, cryoglobulimia is very much associated with HCV and/or its treatment with interferon.
Google: "Thyroid involvement in hepatitis C - associated mixed cryoglobulinemia" (The pdf of the entire study can be found at www.hormones.gr/pdf/Hormones_2014-16.pdf)
Google: "The Renal Manifestations of Thyroid Disease" (or you may find it with this link: jasn.asnjournals.org/content/23/1/22.full) which says,
"Patients with nephrotic syndromes have urinary losses of proteins that bind thyroid hormones, including thyroxine binding globulin, transthyretin, and albumin. This can result in reductions in total plasma T4 and less commonly total T3 levels that are roughly proportional to the severity of hypoalbuminemia and degree of proteinuria."
I also suggest you google the terms:
"Thyroid function in patients with proteinuria"
"Interferon alpha treatment and endocrine disease"
"MGUS and thyroid"
Once you start googling your DXs with "thyroid" I think you will find a wealth of associations with proteinuria, cryoglobulimia, MGUS and thyroid disease.
I hope this helps.
Have an Answer?
You are reading content posted in the Hepatitis C: Post Treatment Issues Community
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Herpes sores blister, then burst, scab and heal.
Herpes spreads by oral, vaginal and anal sex.
STIs are the most common cause of genital sores.
Condoms are the most effective way to prevent HIV and STDs.
PrEP is used by people with high risk to prevent HIV infection.
