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158241 tn?1237719523

Data about osteonecrosis

Does someone know published data about osteonecrosis caused by IFN treatment in other indications than leucaemia, eg hep traetment?
4 Responses
158241 tn?1237719523

Avascular necrosis with interferon alfa-2b in chronic myelogenous leukaemia

Australia - Out of a total of 426 reports involving interferon alfa-2b (Intron A
148588 tn?1465778809
Just one of many reasons IntronA is no longer state-of-the art and most of us take our IFN pegylated.
Signing off from McDonald's.
158241 tn?1237719523
You did not read my posting carefully. The paper describes treatment of leukeamia, not hepatitis. Both diseases are unpleasant, but very different. While hepatitis causes thrombocytopenia very often, leukaemia caused thrombocytosis in the cases described in the australian paper. If you think these cases could have been avoided by using pegulated IFN insetad of IFN, you should have an idea "HOW" IFN causes osteonecrosis and why PEG-IFN could avoid this.
Statements like the one you have posted, telling opinions without any evidence for what is said, are a waste of time.
148588 tn?1465778809
You would have better luck searching HIV forums. Much more "published data about osteonecrosis" and IFN there.

Vielen Gluck
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