Aa
1 week R1626 results - help with interpreting pls
My first week results on the R1626:
Baseline:
VL 2,100,000 IU/ml
ALT 45
AST 31
HGB 132
WBC 6.4
Platelets (which refers to what?) 276
ANC (Neuts?) 4.52 (why is everyone else's in different numbers like thousands?)
1st week
VL 3.06 E5 - what the heck is that? She said 500,000 IU/ml approx
ALT 27
AST 22
HGB 129
WBC 6.0
Plat 300
ANC 4.10
I'm stunned at the drop in my ALT/AST level - it was never all that bad but .. wow.
Not much change in my HGB .. which is good in the one sense... and in the other sense.. looking at the low drop in my VL (at least seems low to me compared to others in this trial and others not on this trial) makes me wonder if the Riba is doing it's job. I'm so sick of peanut butter it isn't funny and it's one of my favourite things.
I'd appreciate some help understanding this, please. I confess, I'm tired and lacking the patience at the moment but I want to understand. A long day at the hospital, long day driving through rush hour to get there and rush hour to get back, 8 hours in all ... and I confess....the seeming low drop in my VL has me just a wee bit down at the moment until I can do the necessary attitude adjustment. I know it's just week one ... was hoping for some of the spectacular drops I've been reading about.
Thanks for your patience.
Trish
Baseline:
VL 2,100,000 IU/ml
ALT 45
AST 31
HGB 132
WBC 6.4
Platelets (which refers to what?) 276
ANC (Neuts?) 4.52 (why is everyone else's in different numbers like thousands?)
1st week
VL 3.06 E5 - what the heck is that? She said 500,000 IU/ml approx
ALT 27
AST 22
HGB 129
WBC 6.0
Plat 300
ANC 4.10
I'm stunned at the drop in my ALT/AST level - it was never all that bad but .. wow.
Not much change in my HGB .. which is good in the one sense... and in the other sense.. looking at the low drop in my VL (at least seems low to me compared to others in this trial and others not on this trial) makes me wonder if the Riba is doing it's job. I'm so sick of peanut butter it isn't funny and it's one of my favourite things.
I'd appreciate some help understanding this, please. I confess, I'm tired and lacking the patience at the moment but I want to understand. A long day at the hospital, long day driving through rush hour to get there and rush hour to get back, 8 hours in all ... and I confess....the seeming low drop in my VL has me just a wee bit down at the moment until I can do the necessary attitude adjustment. I know it's just week one ... was hoping for some of the spectacular drops I've been reading about.
Thanks for your patience.
Trish
Everything looks good to me, and you dropped GREAT FOR ONE WEEK.Watch your HGB and WBC levels. The lower the HGB the lower your oxygen in take, so breathing rate increases and you will get the feeling you ran a marathon. Why I bring this up is your base level is a little low, 100 is the standard limit but ,the study may be different.
Thought this study was about drugs that don't effect the HGB level that much, have you heard that?
Call your study nurse and get her email address, then send your concerns to her and she will answer ASAP. Mine got to know me well and would send scripts to the pharmacy, same day, and email me when blood work came in .
How are you feeling any side effects?
Harry
Thought this study was about drugs that don't effect the HGB level that much, have you heard that?
Call your study nurse and get her email address, then send your concerns to her and she will answer ASAP. Mine got to know me well and would send scripts to the pharmacy, same day, and email me when blood work came in .
How are you feeling any side effects?
Harry
Elaine...good one! I missed that! That IS good for one week!!
Harry...agree on the NP e-mail addy. Also had mines cell phone and she always got back to me ASAP. She is great. Get a good relationship with NP!
sldb....lol. you sound like me on Liz'z post at 3 AM the other night!
Good info tho.
LL
Harry...agree on the NP e-mail addy. Also had mines cell phone and she always got back to me ASAP. She is great. Get a good relationship with NP!
sldb....lol. you sound like me on Liz'z post at 3 AM the other night!
Good info tho.
LL
Okay...now that I've had a wee nap right after I posted that....
I read the post you referenced, read the Janis page, then opened my calculator on my computer and there is an Exp key and when I type in 3.06 and hit Exp I can then enter the exponent which, in this case, is 5. Then it becomes, as per Cocksparrow's explanation in the thread you referenced, 306,000.
So my VL is 306,000 IU/ml, correct?
Thanks for the congrats...I actually just started my 3rd week today ...did my third injection just before I posted that. It's going just fine so far....aside from me being grumpy from a long day. True enough...could have been worse .. thanks for diverting all the Canadians to Florida this week...they'll be back with a vengeance next week! But then my appt is back to 8am instead of midday, easy peasy. :)
I read the post you referenced, read the Janis page, then opened my calculator on my computer and there is an Exp key and when I type in 3.06 and hit Exp I can then enter the exponent which, in this case, is 5. Then it becomes, as per Cocksparrow's explanation in the thread you referenced, 306,000.
So my VL is 306,000 IU/ml, correct?
Thanks for the congrats...I actually just started my 3rd week today ...did my third injection just before I posted that. It's going just fine so far....aside from me being grumpy from a long day. True enough...could have been worse .. thanks for diverting all the Canadians to Florida this week...they'll be back with a vengeance next week! But then my appt is back to 8am instead of midday, easy peasy. :)
Elaine, LL .... thank you for weighing in, appreciate your thoughts.
sldb ... no hct on my results? There is:
ALT, AST, ALP, Bili, Alb, INR, Creat, Gluc, TSH, HG, WBC, Plat, ANC, HCV, Polyl/RBV
Does that make any sense?
The R1626 protocol ensures I'm doing 1200mg Riba daily, either 90ml or 180ml INF weekly and an unknown amount of study drug R1626 in amounts of either 0mg, 500mg, 1000mg or 1500mg bid.
Harry - 300,000 does make me feel better than 500,000. I'm good with that for the first week. I would have liked less but I'm okay with that. Still three weeks of results to go until that 4th week. Yes, you are right.. these study drugs more impact the WBC, so while they monitor the HGB, the concern for the study drug is the WBC.
No real side effects....I haven't been looking for any and they haven't come up to bite me. I've just been pushing through. If anything, I'm working extra hours and on a bit of overdrive. I never could slow down and life has been busy. If I'm going to have sides, they'll have to knock me flat on my a$$ for me to slow down. That's not to say that I'm not trying to fit in rest where I can, I am...but so far I'm good. Mind you .. I've been looking forward to this weekend to just relax. I've been pushing it a bit hard lately.
sldb ... no hct on my results? There is:
ALT, AST, ALP, Bili, Alb, INR, Creat, Gluc, TSH, HG, WBC, Plat, ANC, HCV, Polyl/RBV
Does that make any sense?
The R1626 protocol ensures I'm doing 1200mg Riba daily, either 90ml or 180ml INF weekly and an unknown amount of study drug R1626 in amounts of either 0mg, 500mg, 1000mg or 1500mg bid.
Harry - 300,000 does make me feel better than 500,000. I'm good with that for the first week. I would have liked less but I'm okay with that. Still three weeks of results to go until that 4th week. Yes, you are right.. these study drugs more impact the WBC, so while they monitor the HGB, the concern for the study drug is the WBC.
No real side effects....I haven't been looking for any and they haven't come up to bite me. I've just been pushing through. If anything, I'm working extra hours and on a bit of overdrive. I never could slow down and life has been busy. If I'm going to have sides, they'll have to knock me flat on my a$$ for me to slow down. That's not to say that I'm not trying to fit in rest where I can, I am...but so far I'm good. Mind you .. I've been looking forward to this weekend to just relax. I've been pushing it a bit hard lately.
I never could slow down and life has been busy...............
That was me too!
My bet is your on 180 peg with that drop, but than with little sides??? Course 3 shots in hard to say. Intersting range in the 2 drugs.
I knew my dose's in it, think the curiosity would drive me nuts!
Ll
That was me too!
My bet is your on 180 peg with that drop, but than with little sides??? Course 3 shots in hard to say. Intersting range in the 2 drugs.
I knew my dose's in it, think the curiosity would drive me nuts!
Ll
Congrats Trish - after all is explained, it looks like you are doing well. You are starting from a very decent #'s for WBC / Neutrophil. Well above my baseline so hopefully you will have a bit more fight to avoid the dose reductions I have been getting.
I get the same neutrophil calculations but was told to drop the decimal point and ad a zero to get the common number. Have you been getting complete print outs of your lab results? I was wondering if they are using the same labs for the study. My VL is being done by Cenetron Central Labs in Texas and my blood panel / chemistry is processed by Quintiles labs in Georgia. I looked over my various VL results and the E5 / E6 calc. is not present on any of them and these are unedited reports from the lab.? Just tell them to tell it to you straight! ;)
cheers
B
I get the same neutrophil calculations but was told to drop the decimal point and ad a zero to get the common number. Have you been getting complete print outs of your lab results? I was wondering if they are using the same labs for the study. My VL is being done by Cenetron Central Labs in Texas and my blood panel / chemistry is processed by Quintiles labs in Georgia. I looked over my various VL results and the E5 / E6 calc. is not present on any of them and these are unedited reports from the lab.? Just tell them to tell it to you straight! ;)
cheers
B
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